Dupuytren’s Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives

Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
Dupuytren’s Disease: Anatomy, Pathology, and Presentation....Pages 3-10
Palmar Fibromatosis or the Loss of Flexibility of the Palmar Finger Tissue: A New Insight into the Disease Process of Dupuytren Contracture....Pages 11-20
Basic Thoughts on Dupuytren’s Contracture....Pages 21-26
High Prevalence of Dupuytren’s Disease and Its Treatment in the British National Health Service: An Ongoing Demand....Pages 27-34
Treatment for Dupuytren’s Disease: An Overview of Options....Pages 35-43
Dupuytren’s Disease and Occupation....Pages 45-49
Front Matter....Pages 51-51
The Role of the Myofibroblast in Dupuytren’s Disease: Fundamental Aspects of Contraction and Therapeutic Perspectives....Pages 53-60
Mechanisms of Myofibroblast Differentiation....Pages 61-67
Myofibroblasts and Interactions with Other Cells: Contribution of the Tissue Engineering....Pages 69-75
Dupuytren’s Contracture Versus Burn Scar Contracture....Pages 77-83
Front Matter....Pages 85-85
The Genetic Basis of Dupuytren’s Disease: An Introduction....Pages 87-91
Use of Genetic and Genomic Analyses Tools to Study Dupuytren’s Disease....Pages 93-100
Establishing an Animal Model of Dupuytren’s Contracture by Profiling Genes Associated with Fibrosis....Pages 101-108
Microarray Expression Analysis of Primary Dupuytren’s Contracture Cells....Pages 109-113
A Clinical Genetic Study of Familial Dupuytren’s Disease in the Netherlands....Pages 115-122
The Epidemiology of Dupuytren’s Disease in Bosnia....Pages 123-127
Front Matter....Pages 129-129
A Primer of Collagen Biology: Synthesis, Degradation, Subtypes, and Role in Dupuytren’s Disease....Pages 131-142
The Expression of Collagen-Degrading Proteases Involved in Dupuytren’s Disease Fibroblast-Mediated Contraction....Pages 143-149
Primary Dupuytren’s Disease Cell Interactions with the Extra-cellular Environment: A Link to Disease Progression?....Pages 151-159
Insulin-Like Growth Factor Binding Protein-6: A Potential Mediator of Myofibroblast Differentiation in Dupuytren’s Disease?....Pages 161-165
Front Matter....Pages 129-129
Dupuytren’s Disease Shows Populations of Hematopoietic and Mesenchymal Stem-Like Cells Involving Perinodular Fat and Skin in Addition to Diseased Fascia: Implications for Pathogenesis and Therapy....Pages 167-174
Using Laboratory Models to Develop Molecular Mechanistic Treatments for Dupuytren’s Disease....Pages 175-183
Front Matter....Pages 185-185
Plastic Surgical Management of Scars and Soft Tissue Contractures....Pages 187-193
Cline’s Contracture: Dupuytren Was a Thief – A History of Surgery for Dupuytren’s Contracture....Pages 195-205
Cellulose Implants in Dupuytren’s Surgery....Pages 207-211
Expanded Dermofasciectomies and Full-Thickness Grafts in the Treatment of Dupuytren’s Contracture: A 36-Year Experience....Pages 213-220
Minimizing Skin Necrosis and Delayed Healing After Surgical Treatment for Dupuytren’s Contracture: The Mini-Chevrons Incision....Pages 221-225
Skin Management in Treatment of Severe PIP Contracture by Homo- or Heterodigital Flaps....Pages 227-234
The “Jacobsen Flap” for the Treatment of Stage III–IV Dupuytren’s Disease at Little Finger: Our Review of 123 Cases....Pages 235-242
A Logical Approach to Release of the Contracted Proximal Interphalangeal Joint in Dupuytren’s Disease....Pages 243-248
The Influence of Dupuytren’s Disease on Trigger Fingers and Vice Versa....Pages 249-253
No Higher Self-Reported Recurrence in Segmental Fasciectomy....Pages 255-260
Palmar Cutaneous Branches of the Proper Digital Nerves Encountered in Dupuytren’s Surgery: A Cadaveric Study....Pages 261-263
Front Matter....Pages 265-265
A Technique of Needle Aponeurotomy for Dupuytren’s Contracture....Pages 267-279
Three-Year Results of First-Ever Randomized Clinical Trial on Treatment in Dupuytren’s Disease: Percutaneous Needle Fasciotomy Versus Limited Fasciectomy....Pages 281-288
Management of Dupuytren’s Disease with Needle Aponeurotomy: The Experience at the Hand and Upper Limb Centre, Canada....Pages 289-292
Percutaneous Needle Fasciotomy: A Serious Alternative?....Pages 293-296
Dynamic External Fixation in the Treatment of Dupuytren’s Contracture....Pages 297-303
Hand Therapy for Dupuytren’s Contracture....Pages 305-316
Severity of Contracture and Self-Reported Disability in Patients with Dupuytren’s Contracture Referred for Surgery....Pages 317-321
Front Matter....Pages 265-265
Night-Time Splinting After Fasciectomy or Dermofasciectomy for Dupuytren’s Contracture: A Pragmatic, Multi-centre, Randomised Controlled Trial....Pages 323-332
The Role of Static Night Splinting After Contracture Release for Dupuytren’s Disease: A Preliminary Recommendation Based on Clinical Cases....Pages 333-339
Front Matter....Pages 341-341
Injectable Collagenase ( Clostridium histolyticum ) for Dupuytren’s Contracture: Results of the CORD I Study....Pages 343-347
Long-Term Outcome of Radiotherapy for Early Stage Dupuytren’s Disease: A Phase III Clinical Study....Pages 349-371
Outcomes of Using Bioengineered Skin Substitute (Apligraf®) for Wound Coverage in Dupuytren’s Surgery....Pages 373-378
Highly Dosed Tamoxifen in Therapy-Resisting Dupuytren’s Disease....Pages 379-386
Screening of Prodrugs on Cells Grown from Dupuytren’s Disease Patients....Pages 387-391
Relaxin: An Emerging Therapy for Fibroproliferative Disorders....Pages 393-400
Cryotherapy and Other Therapeutical Options for Plantar Fibromatosis....Pages 401-407
Long-Term Outcome of Radiotherapy for Primary and Recurrent Ledderhose Disease....Pages 409-427
Medical Management of Peyronie’s Disease....Pages 429-437
Front Matter....Pages 439-439
The Patient’s Perspective and the International Dupuytren Society....Pages 441-447
IDUP: Proposal for an International Research Database....Pages 449-454
The Future of Dupuytren’s Research and Treatment....Pages 455-470
Back Matter....Pages 471-474