Drugs and the Elderly: Perspectives in Geriatric Clinical Pharmacology

Front Matter....Pages i-x
Front Matter....Pages 1-1
The biochemical background to current theories of ageing....Pages 3-13
Pathophysiology of ageing in animal models....Pages 15-22
Criteria for the design of an animal-holding facility for ageing animals as illustrated by the Wolfson Laboratory for Research in Gerontology....Pages 23-31
The pathophysiology of ageing in man: the place of the cell....Pages 33-38
Ageing and nutrition....Pages 39-47
Front Matter....Pages 49-49
Studies on drug absorption and metabolism in the elderly....Pages 51-63
Drug distribution in the elderly....Pages 65-76
Renal excretion of drugs....Pages 77-87
Digoxin pharmacokinetics in the elderly....Pages 89-101
The effects of ageing on the disposition of benzodiazepines in man....Pages 103-116
Pharmacokinetics of lignocaine and chlormethiazole in the elderly; with some preliminary observations on other drugs....Pages 117-132
Age, depression and tricyclic antidepressant levels....Pages 133-144
Front Matter....Pages 145-145
Drug sensitivity in the elderly....Pages 147-153
Assessment of psychotropic drug effects....Pages 155-167
Increased sensitivity to benzodiazepines in the elderly....Pages 169-178
Response to anaesthetic drugs in the elderly....Pages 179-187
Monoamines and their metabolites and monoamine oxidase activity related to age and to some dementia disorders....Pages 189-197
Warfarin sensitivity in the elderly....Pages 199-209
Barbiturate sensitivity in ageing animals....Pages 211-219
Front Matter....Pages 221-221
Drug-prescribing patterns in the elderly — A general practice study....Pages 223-229
Front Matter....Pages 221-221
A survey of hospital prescribing for the elderly....Pages 231-238
Adverse reactions to prescribed drugs in the elderly....Pages 239-246
Treatment of hypertension in the elderly....Pages 247-262
Postural hypotension in the elderly....Pages 263-265
Drugs and confusional states....Pages 267-277
Drug dosage in the elderly — Theory and practice....Pages 279-286
Compliance problems....Pages 287-291
Conclusions: Perspectives in geriatric clinical pharmacology....Pages 293-295
Back Matter....Pages 297-304