Drug Resistance in Leukemia and Lymphoma III

Front Matter....Pages i-xiv
MDR1/P-GP Expression as A Prognostic Factor in Acute Leukemias....Pages 1-9
Clinical Significance of P-Glycoprotein (P-gp) Expression in Childhood Acute Lymphoblastic Leukemia....Pages 11-19
Prognostic Value of P-gp Expression and Related Function in Childhood Acute Leukemia....Pages 21-28
Comparison of P-Glycoprotein Expression and Function with in vitro Sensitivity to Anthracyclines in AML....Pages 29-33
Quinine Improves Results of Intensive Chemotherapy (IC) in Myelodysplastic Syndromes (MDS) Expressing P-Glycoprotein (PGP)....Pages 35-46
Treatment of Poor Prognosis AML Patients Using PSC833 (Valspodar) Plus Mitoxantrone, Etoposide, and Cytarabine (PSC-MEC)....Pages 47-56
Assessment of P-Glycoprotein Expression by Immunocytochemistry and Flow Cytometry Using Two Different Monoclonal Antibodies Coupled with Functional Efflux Analysis in 34 Patients with Acute Myeloid Leukemia....Pages 57-63
Preliminary Immunocytochemical Studies of MDR-1 and MDR-3 Pgp Expression in B-Cell Leukaemias....Pages 65-70
A Mutation in the Promoter of the Multidrug Resistance Gene ( MDR1 ) in Human Hematological Malignancies may Contribute to the Pathogenesis of Resistant Disease....Pages 71-75
Reproducible Flow Cytometric Methodology for Measuring Multidrug Resistance in Leukaemic Blasts....Pages 77-88
Natural Fluorescence Imaging of Leukemic Cells for Studying Uptake and Retention of Anthracyclines....Pages 89-94
Artificial Neural Networks as Versatile Tools for Prediction of MDR-Modulatory Activity....Pages 95-105
Discordance of P-Glycoprotein Expression and Function in Acute Leukemia....Pages 107-118
Multidrug Resistance Related Proteins in Primary Cutaneous Lymphomas....Pages 119-131
The Lung Resistance Protein (LRP) Predicts Poor Outcome in Acute Myeloid Leukemia....Pages 133-139
MRP Expression in Acute Myeloid Leukemia....Pages 141-150
Evidence for Functional Discrimination Between Leukemic Cells Overexpressing Multidrug-Resistance Associated Protein and P-Glycoprotein....Pages 151-160
Both Pgp and MRP1 Activities Using Calcein-AM Contribute to Drug Resistance in AML....Pages 161-175
Absolute Levels of MDR-1, MRP, and BCL-2 MRNA and Tumor Remission in Acute Leukemia....Pages 177-185
Multidrug Resistance Protein MRP1, Glutathione, and Related Enzymes....Pages 187-198
Glutathione and the Regulation of Cell Death....Pages 199-203
Evidence for the Involvement of the Glutathione Pathway in Drug Resistance in AML....Pages 205-209
Glutathione in Childhood Acute Leukaemias....Pages 211-216
Apoptosis....Pages 217-236
Activation of Apoptosis Pathways by Anticancer Drugs....Pages 237-244
BCL-2 Stimulates Apoptin®-Induced Apoptosis....Pages 245-249
CD95 (FAS/APO-1) Antigen is a New Prognostic Marker of Blast Cells of Acute Lymphoblastic Leukaemia Patients....Pages 251-258
Inhibition of FAS/FAS-Ligand Does Not Block Chemotherapy-Induced Apoptosis in Drug Sensitive and Resistant Cells....Pages 259-266
Effects of Parp Inhibition on Drug and FAS-Induced Apoptosis in Leukaemic Cells....Pages 267-279
Apoptotic Fraction in Childhood All Assessed by DNA in situ Labelling is Ploidy Independent....Pages 281-287
PCNA Bearing Structures are Retained in Apoptotic Phase of Childhood All Cell Cycle....Pages 289-296
Apoptosis Corrected Proliferation Fraction in Childhood All is Related to Karyotype....Pages 297-303
Proliferation and Apoptosis Does Not Affect Presenting White Cell Count in Childhood All....Pages 305-312
Apoptosis by Anthracyclines at Therapeutic Concentrations in MDR1+ Human Leukemic Cells....Pages 313-324
BCL-2 Expression in Childhood Leukemia Versus Spontaneous Apoptosis, Drug Induced Apoptosis, and in vitro Drug Resistance....Pages 325-333
Comparison of BCL-2 and Bax Protein Expression with in vitro Sensitivity to ARA-C and 6TG in AML....Pages 335-340
Synthetic Cyclin Dependent Kinase Inhibitors....Pages 341-353
Factors Contributing to the Resistance to Apoptosis Induced by Topoisomerase I Inhibitors in Vincristine Resistant Cells....Pages 355-363
Two Distinct Modes of Oncoprotein Expression During Apoptosis Resistance in Vincristine and Daunorubicin Multidrug-Resistant HL60 Cells....Pages 365-381
Genetic Abnormalities and Drug Resistance in Acute Lymphoblastic Leukemia....Pages 383-389
Resistance Testing and Mechanisms of Resistance in Childhood Leukemia....Pages 391-395
Pharmacokinetics of Anticancer Drugs In Vitro....Pages 397-407
Down Syndrome and Acute Myeloid Leukemia....Pages 409-414
Cellular Drug Resistance in Childhood Acute Myeloid Leukemia....Pages 415-421
Is In Vitro Sensitivity of Blast Cells Correlated to Therapeutic Effect in Childhood Acute Lymphoblastic Leukemia?....Pages 423-428
In Vitro Cytotoxic Drug Activity and In Vivo Pharmacokinetics in Childhood Acute Myeloid Leukemia....Pages 429-435
Prognosis in Adult AML is Precisely Predicted by the Disc-Assay Using the Chemosensitivity-Index C I ....Pages 437-444
Drug Resistance Testing of Acute Myeloid Leukemia in Adults Using the MTT Assay....Pages 445-452
MTT Assay for Drug Resistance in Childhood Acute Leukemia and Effect of Cyclosporin and Interferon....Pages 453-459
Differential Antileukemic Activity of Prednisolone and Dexamethasone in Freshly Isolated Leukemic Cells....Pages 461-471
Activity of Vinorelbine on B-Chronic Lymphocytic Leukemia Cells In Vitro ....Pages 473-476
Studies of Some Mechanisms of Drug Resistance in Chronic Myeloid Leukemia (CML)....Pages 477-488
Clinical Sensitivity to Anthracyclines in PH/BCR+ Acute Lymphoblastic Leukemia....Pages 489-499
Differential Kinetics of Drug Resistance in Human Leukaemic Cells Measured by SCGE/CLSM....Pages 501-508
Demonstration of Differences in Drug Resistance by Direct Testing of DNA Excision Repair Activity Following Standard and Liposomal Daunorubicin Exposure in Normal Paediatric Marrow Using High Resolution CLSM....Pages 509-516
Microsatellite Instability Assessment in Prediction of Drug Resistance in Childhood Burkitt’s and Large Cell Diffuse Malignant Non-Hodgkin Lymphoma (MNHL)....Pages 517-525
High Resolution Confocal Laser Scanning Microscopy Analysis of DNA Excision Repair Capability in Small Volume Marrow Samples Exposed to DNA Directed Treatment Moieties....Pages 527-535
Defining the Optimal Dosage of Methotrexate for Childhood Acute Lymphoblastic Leukemia....Pages 537-541
Mechanisms of Methotrexate Resistance in Acute Leukemia....Pages 543-550
Lack of Cross-Resistance Between Prednisolone and Methotrexate in Childhood Acute Lymphoblastic Leukemia?....Pages 551-555
New Developments in the Treatment of Acute Myeloid Leukemia....Pages 557-565
Aphidicolin Markedly Increases the In Vitro Sensitivity to ARA-C of Blast Cells From Patients with AML....Pages 567-570
Common Resistance Mechanisms to Nucleoside Analogues in Variants of the Human Erythroleukemic Line K562....Pages 571-577
Expression of DNA Mismatch Repair Proteins in Acute Lymphoblastic Leukaemia and Normal Bone Marrow....Pages 579-583
Effects of CSFS and their Combinations with Chemotherapeutic Agents (CH) on Leukemic Blasts (LB) in Children (MTT-Assay)....Pages 585-592
Glucocorticosteroid Therapy in Childhood Acute Lymphoblastic Leukemia....Pages 593-605
Glucocorticoid Induced Apoptosis in Leukemia....Pages 607-614
Glucocorticoid Resistance and the AP-1 Transcription Factor in Leukaemia....Pages 615-619
The Three Asparaginases....Pages 621-629
Back Matter....Pages 631-638