Drug-Induced Liver Disease (2nd Edition)

Preface......Page 4
Contents......Page 6
Contributors......Page 10
Drug-Induced Liver Disorders: Introduction and Overview......Page 14
The Role of Cytochrome P450s in Drug-Induced Liver Disease......Page 28
Oxidative Stress, Antioxidant Defense, and Liver Injury......Page 48
Hepatotoxicity Due to Mitochondrial Injury......Page 68
Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity......Page 98
The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis......Page 110
Immunological Mechanisms in Liver Injury......Page 138
Mechanistic Role of Acyl Glucuronides......Page 164
Nonparenchymal Cells, In.ammatory Macrophages, and Hepatotoxicity......Page 196
Roles of Cytokines and Growth Factors in Liver Regeneration, Repair, and Fibrosis after Liver Injury......Page 226
Clinicopathological Patterns of Drug-Induced Liver Disease......Page 240
Histopathology of Drug-Induced Liver Disease......Page 256
Mechanisms of Acetaminophen- Induced Liver Disease......Page 300
Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity......Page 340
Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-In.ammatory Drugs......Page 358
Nonsteroidal Anti-In.ammatory Drugs: Pathology and Clinical Presentation of Hepatotoxicity......Page 390
Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents......Page 418
Anticonvulsant Agents......Page 438
Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse......Page 460
Antibacterials and Antifungal Agents......Page 484
Antituberculous Agents–Induced Liver Injury......Page 518
Hepatic Injury from Antiviral Agents......Page 532
Hepatotoxicity of Cardiovascular and Antidiabetic Drugs......Page 562
Cancer Chemotherapy......Page 606
Immunomodulating Agents and the Transplant Situation......Page 646
Methotrexate Controversies......Page 666
Adverse Effects of Hormones and Hormone Antagonists on the Liver......Page 690
Alternative Medicine, Vitamins, and Natural Hepatotoxins......Page 722
Occupational and Environmental Hepatotoxicity......Page 738
Regulatory Perspectives......Page 752
Index......Page 768