Drug Determination in Therapeutic and Forensic Contexts

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Separation Science Applied to Analyses on Biological Samples....Pages 3-16
Sample Handling in Forensic Toxicology....Pages 17-26
Stable Isotopes in Pharmacokinetic Studies....Pages 27-37
Isotope-Labelled Materials as Internal Standards....Pages 39-44
Front Matter....Pages 45-45
Approaches for Determining Ethylenediamine and its Metabolites: Use of [ 14 C]- and [D 4 ]-Ethylenediamine....Pages 47-52
Selective Sample Preparation Techniques for Trace Analysis....Pages 53-58
Simplified Approaches to the HPLC Determination of Drugs in Biological Samples....Pages 59-62
Front Matter....Pages 63-63
Development and Application of an HPLC Pre-Concentration Device Suitable for Large Amounts of Biological Sample....Pages 65-70
Multi-Solvent Optimization of HPLC Separations....Pages 71-80
Optimization Strategies for Chromatographic Analysis of Multi-Component Mixtures....Pages 81-89
Reversed-Phase TLC on Alkyl-Bonded and Paraffin-Coated Silica Gel....Pages 91-96
Front Matter....Pages 97-97
Chemically Bonded Stationary Phases in (HP)TLC....Pages 99-100
TLC as a Pilot Technique for Reversed-Phase HPLC....Pages 101-106
Front Matter....Pages 109-109
Comparative Performance of Different HPLC Systems with Electrochemical Detection....Pages 111-121
Specific Element Chromatographic Detection by Plasma Spectral Emission, as Applied to Organometallics and Gold-Containing Drugs....Pages 123-138
HPLC-Electrochemical Determination of CIS -Platinum Anti-Cancer Drugs....Pages 139-144
HPLC Analysis of Cisplatin Analogues in Biological Fluids....Pages 145-153
The Therapeutic Use of Gold Compounds: Analytical Aspects....Pages 155-160
Clinical Analysis of Divalent Platinum Complexes with Anti-Neoplastic Activity....Pages 161-172
Solid Phase Derivatization Reactions in HPLC....Pages 173-179
Front Matter....Pages 181-181
Post-Column Reaction Detectors for Trace Analysis in HPLC....Pages 183-184
Post-Column Reaction with Ferric Chloride for the Detection of D-Penicillamine....Pages 185-188
An Evaluation of a Two-Electrode Coulometric Detector....Pages 189-190
A Comparison of the Moving Belt and Direct Liquid Introduction Interfaces for HPLC-MS of Ranitidine and its Metabolites....Pages 191-194
Front Matter....Pages 199-199
Determination of the Anti-Cancer Drug Amsacrine in Biological Fluids by HPLC....Pages 201-209
Over-View of Problems in Determining Tamoxifen Levels in Biological Samples....Pages 211-217
Analysis of Tamoxifen and its Metabolites....Pages 219-225
HPLC Methodology for Therapeutic Monitoring of Tamoxifen and Two Major Metabolites in Blood and Tissues....Pages 227-234
Analyses for Tamoxifen, its Metabolites and Endogenous Oestrogens in Blood Plasma and Tumour Tissue....Pages 235-240
Front Matter....Pages 241-241
Determination of Tamoxifen and N -Desmethyltamoxifen in Plasma by HPLC....Pages 243-244
Identification of Adriamycin and its Metabolites in Human and Animal Tissue and Blood....Pages 245-246
Antibodies to Deoxycytidine Triphosphate (dCTP) Suitable for its Radioimmunoassay....Pages 247-248
Combined RIA/HPLC of Methotrexate and its Metabolites....Pages 249-250
Radioimmunoassay of Methotrexate....Pages 251-258
Front Matter....Pages 259-259
Radioimmunoassay in Forensic Science....Pages 261-268
Spin Immunoassay for Drug Determination....Pages 269-274
Advent and Present-Day Status of Ligand Methods....Pages 275-285
Radioreceptor Assay of Anticholinergic Drugs in Biological Fluids....Pages 287-296
Receptor Binding and HPLC Analysis of Benzodiazepines in a Clinical Laboratory....Pages 297-302
Front Matter....Pages 303-303
Assay of Secoverine and Active Metabolites: Comparison of Stable Isotope Dilution with Receptor Binding Assay....Pages 305-310
Front Matter....Pages 303-303
Some Trends in Ligand Methods, Including Fluoroimmunoassay....Pages 311-312
Plasma Morphine: Comparison of Results Obtained By HPLC and RIA....Pages 313-316
Front Matter....Pages 317-317
HPLC with Electrochemical Detection: Applications for the Neurosciences....Pages 319-330
Gas Chromatography with Electron-Capture Detection for Measurement of Bioactive Amines in Biological Samples....Pages 331-336
Analysis of the Metabolites of Bumetanide in Urine by HPLC....Pages 337-342
Assay of Compounds of Forensic Interest....Pages 343-356
Detection of Solvent Abuse by Direct Mass Spectrometry on Expired Air....Pages 357-362
Front Matter....Pages 363-363
Explosives and other Nitro Compounds Determined By Liquid Chromatography with Photolysis-Electrochemical Detection....Pages 365-366
Nitroglycerin Assay in Plasma by Thermal Energy Analyzer....Pages 367-368
A Comparison of HPLC-Thermal Energy Analysis and GC-Electron Capture Detection for Determining Isosorbide Dinitrate and Its Mononitrate Metabolites in Human Plasma....Pages 369-374
Front Matter....Pages 375-375
The Role of External Quality Assessment Schemes in the Determination of Plasma Drug Levels....Pages 377-384
Validation of Bioanalytical Procedures: An Example....Pages 385-392
Front Matter....Pages 393-393
GLP in a Chemical-Pharmaceutical Company: Current Status and Experiences in Analytical and Drug Disposition Department....Pages 395-397
Quality Control Systems for Routine Drug Analysis....Pages 399-403
Back Matter....Pages 407-419