Drug Design

Content: 
MEDICINAL CHEMISTRY, Page ii
Front Matter, Page iii
Copyright, Page iv
List of Contributors, Pages xi-xii
Preface, Page xiii, E.J. ARIËNS
Introduction, Pages xv-xvi, GEORGE H. HITCHINGS
Contents of Other Volumes, Pages xvii-xviii
Chapter 1 - Modulation of Pharmacokinetics by Molecular Manipulation, Pages 1-127, E.J. Ariëns
Chapter 2 - Factors in the Design of Reversible and Irreversible Enzyme Inhibitors, Pages 129-160, Howard J. Schaeffer
Chapter 3 - The Design of Organophosphate and Carbamate Inhibitors of Cholinesterases, Pages 161-212, R.D. O'Brien
Chapter 4 - The Design of Reactivators for Irreversibly Blocked Acetylcholinesterase, Pages 213-229, I.B. Wilson, Harry C. Froede
Chapter 5 - Inhibition of Protein Biosynthesis: Its Significance in Drug Design, Pages 231-249, Arthur P. Grollman
Chapter 6 - Enzymes and Their Synthesis as a Target for Antibiotic Action, Pages 251-260, M.H. Richmond
Chapter 7 - The Rational Design of Antiviral Agents, Pages 261-276, Arthur P. Grollman, Susan B. Horwitz
Chapter 8 - Design of Penicillins, Pages 277-318, A.E. Bird, J.H.C. Nayler
Chapter 9 - The Design of Peptide Hormone Analogs, Pages 319-419, J. Rudinger
Chapter 10 - Recent Advances in the Design of Diuretics, Pages 421-435, George deStevens
Chapter 11 - Design of Biologically Active Steroids, Pages 437-452, G.A. Overbeek, J. van der Vies, J. de Visser
Chapter 12 - Rational Elements in the Development of Superior Neuromuscular Blocking Agents, Pages 453-530, M. Martin-Smith
Chapter 13 - The Design of Tumor-Inhibitory Alkylating Drugs, Pages 531-571, J.A. Stock
Author Index, Pages 573-616
Subject Index, Pages 617-645