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ویرایش: نویسندگان: Felix Kratz, Peter Senter, Henning Steinhagen سری: ISBN (شابک) : 9783527328239 ناشر: Wiley-VCH سال نشر: 2012 تعداد صفحات: 1738 زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 28 مگابایت
در صورت تبدیل فایل کتاب Drug Delivery in Oncology: From Basic Research to Cancer Therapy به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب تحویل دارو در انکولوژی: از تحقیقات اساسی گرفته تا سرطان درمانی نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Volume 1: PRINCIPLES OF TUMOR TARGETING Limits of Conventional Cancer Chemotherapy Pathophysiological and Vascular Characteristics of Tumors in Relation to Drug Delivery Enhanced Permeability and Retention Effect in Relation to Tumor Targeting Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - Basic Principles and its Practice So Far TUMOR IMAGING Imaging Techniques in Drug Development and Clinical Practice Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT Volume 2: MACROMOLECULAR DRUG DELIVERY SYSTEMS Antibody-Based Systems Empowered Antibodies for Cancer Therapy Mapping Accessible Vascular Targeting to Penetrate Organs and Solid Tumors Considerations of Linker Technologies Antibody-Maytansinoid Conjugates: From the Bench to the Clinic Calicheamicin Antibody-Drug Conjugates and Beyond Antibodies for the Delivery of Radionuclides Bispecific Antibodies and Immune Therapy Targeting POLYMER-BASED SYSTEMS Design of Polymer-Drug Conjugates Dendritic Polymers in Oncology: Facts, Features, and Applications Site-Specific Prodrug Activation and the Concept of Self-Immolation Ligand-Assisted Vascular Targeting of Polymer Therapeutics Drug Conjugates with Poly(Ethylene)Glycole Thermo-Responsive Polymers Polysaccharide-Based Drug Conjugates for Tumor Targeting Serum Proteins as Drug Carriers of Anticancer Agents Future Trends, Challenges, and Opportunities with Polymer-Based Combination Therapy in Cancer Clinical Experience with Drug-Polymer Conjugates NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS - LIPID-BASED SYSTEMS Overview on Nanocarriers as Delivery Systems Development of PEGylated Liposomes Immunoliposomes Responsive Liposomes (for Solid Tumor Therapy) Nanoscale Delivery Systems for Combination Chemotherapy NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS - POLYMER-BASED SYSTEMS Micellar Strcutures as Drug Delivery Systems Tailor-Made Hydrogels for Tumor Delivery pH-Triggered Micelles for Tumor Delivery Albumin-Drug Nanoparticles Carbon Nanotubes Volume 3: LIGAND-BASED DRUG DELIVERY SYSTEMS Cell-Penetrating Peptides in Cancer Targeting Targeting to Peptide Receptors Aptamer Conjugates: Emerging Delivery Platforms for Targeted Cancer Therapy Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors Drug Conjugates with Polyunsaturated Fatty Acids SPECIAL TOPICS RNA Drug Delivery Approaches Local Gene Delivery for Therapy of Solid Tumors Viral Vectors for RNA Interference Applications in Cancer Research and Therapy Design of Targeted Protein Toxins Drug Targeting to the Central Nervous System Liver Tumor Targeting Photodynamic Therapy: Photosensitizers Targeting and Delivery Tumor-Targeting Strategies with Anticancer Platinum Complexes