Drug Delivery Aspects: Expectations and Realities of Multifunctional Drug Delivery Systems: Volume 4: Expectations and Realities of Multifunctional Drug Delivery Systems

Cover
DRUG DELIVERY ASPECTS:
EXPECTATIONS AND REALITIES OF
MULTIFUNCTIONAL DRUG
DELIVERY SYSTEMS
Copyright
Contributors
Preface
1
Versatile hyaluronic acid nanoparticles for improved drug delivery
	Introduction
	Hyaluronic acid
		Chemistry
		Sources
		Physiological role
		Turnover and elimination pathways
	Preparation of hyaluronic acid nanoparticles
		Conjugate formation
		Self-assemblies formation
		Ionic nanocomplexes formation
		Nanogels formation
	Applications of HA nanoparticles
		Skin applications
		Osteoarthritis
		Tissue engineering
		Cancer targeting
		Atherosclerosis
		Ocular drug delivery
		Insulin sensitivity and diabetes
		Theranostic and imaging
	Clinical status
	Conclusion
	References
2
Preclinical testing-Understanding the basics first
	Introduction
	Preclinical studies
	Regulatory aspects of preclinical studies
	Preclinical testing and models used
		In vitro assays/cell line assays
	Animal models and type of tests
		In vivo evaluation
		Pharmacodynamics
		Pharmacokinetic
		Toxicology
		Advances in the field
		Databases
	Conclusion
	References
3
Aqueous polymeric coatings: New opportunities in drug delivery systems
	Introduction
	Coating types and polymers used
		Aqueous-based coatings for sustained drug release (cellulosic type)
			Ethylcellulose
		Aqueous-based coatings for enteric drug release
			Cellulose acetate phthalate
			Hydroxypropyl methylcellulose acetate
		Acrylate-type aqueous-based coatings
			Ammonio methacrylate copolymers
			Ethyacrylate methylmethacrylate
			Methacrylic acid copolymers for enteric drug release
		Aqueous-based flexible polymer coatings for sustained drug release
			Polyvinyl acetate
	Strategies to improve storage stability
		Optimization of curing conditions
		Plasticizer type and content
		Addition of high Tg polymers
		Addition of hydrophilic excipients
		High solids content
	Solidification of self-nanoemulsifying drug delivery systems by fluid bed coating
	Conclusion
	References
4
Large-scale manufacturing of nanoparticles-An industrial outlook
	Introduction
	Nanosuspensions
		Top-down approach
		Bottom-up approach
		Considerations on scale-up from lab to industrial scale
		Large-scale manufacturing unit operation
	Lipid nanoparticles
	Nanoparticle characterization and analytical techniques used
		Other characterizations
	Conclusion
	References
5
The role of polymers and excipients in developing amorphous solid dispersions: An industrial perspective
	Introduction
	ASD versus other solubilization techniques
	ASD relevance to different pharmaceutical businesses
	Considerations in developing ASDs
		Thermodynamic and kinetic considerations
		Feasibility considerations
	Critical functionality attributes of polymers and excipients with respect to the manufacturing process
	Manufacturing process considerations
		Spray drying
		Hot-melt extrusion
			Melt rheology considerations
	Applications
		Future trends and technology landscape
	Regulatory considerations
	Marketed ASD products
	Conclusion
	References
	Further reading
6
Biologics: Delivery options and formulation strategies
	Introduction
	Intravenous infusion of biopharmaceuticals
	Subcutaneous injection of biopharmaceuticals
	Targeted localized delivery of biologics
		Brain targeting
		Pulmonary delivery
		Transdermal delivery
		Ocular delivery
		Oral delivery
	Formulation strategies, degradation routes, and role of excipients
		Surfactants
		Buffers
		Lyoprotectors (sugar)/bulking agents
		Salts
		Antimicrobial preservatives
		Additional formulation considerations
			Adjuvants in vaccine formulation
			Stability of biologics, typical shelf life and storage considerations
			Toxicity and immunogenicity of biologics
	Conclusion
	References
7
Ethical issues in research and development of nanoparticles
	Introduction
	Safety of nanoparticles and production methods
	Applications and handling of nanoparticles
	Impact of nanotechnology on society, environment, and health
	Ethical issues and socioeconomic concerns
	Conclusions
	Acknowledgments
	References
8
Sterilization of pharmaceutical dosage forms
	Introduction
	Challenges in sterilization
		Dosage forms and sterilization methods
		Compounding and manufacturing of sterile dosage forms
	Challenges in manufacturing
		Aspects on compounding area
		Validation of aseptic processing
	Types of sterilization methods
		Dry heat sterilization
		Moist heat sterilization
		Radiation sterilization
		Filtration sterilization
		Chemical agents
	Other techniques
		Lyophilization
			Quality by design
			Process analytical technology
	End storage, handling of drugs and drug products
	Conclusion
	References
	Further reading
9
Vaccine delivery strategies against botulism
	Introduction
	Vaccines
		Toxoid and recombinant protein vaccines
		DNA vaccines against BoNT
		Viral vector vaccines against BoNT
			Inactivated rabies virus vector
			Influenza A virus vector
			Adenovirus-based vectors
			VEE vectors
			Lactic acid bacterial (LAB) vectors
	Botulism antitoxin
	Clinical trials of therapeutic and prophylactic vaccine candidates
	Conclusion
	References
10
Nanotechnological approaches for delivery of antiinflammatory drugs
	Introduction
	Potential of nanocarriers for delivery of antiinflammatory drugs
		Polymeric nanoparticles
		Nanoemulsions
		Nanosuspensions
	Conclusion
	References
	Further reading
11
Food to medicine transformation of stilbenoid vesicular and lipid-based nanocarriers: Technological advances
	Introduction
	Stilbenoids
	Delivery challenges
	Nanocarriers for delivery
		Vesicular nanocarriers
			Liposomes
			Niosomes
			Penetration enhancer vesicles (PEVs)
			Ethosomes and transfersomes
		Lipid-based carriers
			Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)
			Nanoemulsions and microemulsions
			Nanocapsules
	Other nanocarriers
	Conclusions
	References
Index
	A
	B
	C
	D
	E
	F
	G
	H
	I
	K
	L
	M
	N
	O
	P
	Q
	R
	S
	T
	U
	V
	W
	Z