Down Syndrome: From Understanding the Neurobiology to Therapy

Content: 
Series Page
Page ii

Copyright
Page iv

List of Contributors
Pages v-vi

Preface
Page vii
Mara Dierssen, Rafael de la Torre

Chapter 1 - Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future
Pages 1-14
Rafael de la Torre, Mara Dierssen

Chapter 2 - Genomic determinants in the phenotypic variability of Down syndrome
Pages 15-28
Audrey Letourneau, Stylianos E. Antonarakis

Chapter 3 - Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario
Pages 29-51
Barbara Bardoni, Sabiha Abekhoukh, Samantha Zongaro, Mireille Melko

Chapter 4 - Aberrant epigenetic landscape in intellectual disability
Pages 53-71
J.V. Sanchez-Mut, D. Huertas, M. Esteller

Chapter 5 - Pathways to cognitive deficits in Down syndrome
Pages 73-100
Xiaolu Sturgeon, Thanh Le, Md. Mahiuddin Ahmed, Katheleen J. Gardiner

Chapter 6 - Neurological phenotypes for Down syndrome across the life span
Pages 101-121
Ira T. Lott

Chapter 7 - Human and mouse model cognitive phenotypes in Down syndrome: implications for assessment
Pages 123-151
Jamie O. Edgin, Gina M. Mason, Goffredina Spanò, Andrea Fernández, Lynn Nadel

Chapter 8 - Perturbation of dendritic protrusions in intellectual disability
Pages 153-168
Josien Levenga, Rob Willemsen

Chapter 9 - The in vivo Down syndrome genomic library in mouse
Pages 169-197
Yann Herault, Arnaud Duchon, Emilie Velot, Damien Maréchal, Véronique Brault

Chapter 10 - Discoveries in Down syndrome: moving basic science to clinical care
Pages 199-221
A.M. Kleschevnikov, P.V. Belichenko, A. Salehi, C. Wu

Chapter 11 - A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome
Pages 223-236
Duane G. Currier, Renita C. Polk, Roger H. Reeves

Chapter 12 - Gene therapy for Down syndrome
Pages 237-247
Cristina Fillat, Xavier Altafaj

Subject Index
Pages 249-260

Volume in series
Pages 261-262