Dopamine Research Advances

DOPAMINE RESEARCH ADVANCES......Page 3
NOTICE TO THE READER......Page 6
CONTENTS......Page 7
PREFACE......Page 9
ABSTRACT......Page 15
PHARMACOLOGY OF CENTRAL DOPAMINE......Page 16
DOPAMINE AND SLEEP REGULATION......Page 18
DOPAMINERGIC DISORDERS AND SLEEP:PARKINSON’S DISEASE......Page 20
REM Behavior Disorder......Page 21
DOPAMINE AND STIMULANT-INDUCED AROUSAL......Page 23
REFERENCES......Page 26
ABSTRACT......Page 31
INTRODUCTION......Page 32
Dopaminergic Modulation of Neurotransmission......Page 33
Functional Modulation by DA......Page 34
Computational Studies......Page 35
Prefrontal Cortical Circuit......Page 36
Dopaminergic Modulation via D1 Receptors......Page 37
The Inverted-U Shape Modulation......Page 38
A Control System Example......Page 39
Mode Diagram......Page 41
Operating Points......Page 43
Circuit Dynamics of the H Mode......Page 44
Evidence for H-Mode Activity......Page 46
COMT......Page 48
Functional Roles of GABA......Page 49
GABAergic Inhibition in Schizophrenia......Page 50
The Circuit Dynamics Theory of the PFC......Page 51
REFERENCES......Page 52
ABSTRACT......Page 65
THE SNC DAERGIC NEURONS......Page 67
THE BIRTH OF SNC DAERGIC NEURONS......Page 68
THE DEATH OF THE SNC DAERGIC NEURONS......Page 69
NEUROINFLAMMATION......Page 72
HOW THE DAERGIC NEURONS DIE......Page 80
THE SNC DAERGIC NEURONS RESURRECTION......Page 81
EXPERT COMMENTARY AND FIVE-YEARS VIEW......Page 83
REFERENCES......Page 84
ABSTRACT......Page 101
DOPAMINE SYSTEMS......Page 102
SEROTONIN SYSTEMS......Page 103
The 5-HT2 Receptor Family......Page 104
5-HT2C RECEPTORS AND DOPAMINE FUNCTION......Page 106
Depression......Page 108
Schizophrenia......Page 110
Drugs of Abuse......Page 112
CONCLUSION......Page 113
REFERENCES......Page 114
ABSTRACT......Page 127
INTRODUCTION......Page 128
Animals and Experimental Design......Page 129
Transmission Electron Microscopy......Page 130
Hormone Assay......Page 131
Transmission Electron Microscopy......Page 132
Hormone Assay......Page 136
CONCLUSION......Page 138
REFERENCES......Page 141
ABSTRACT......Page 145
SEROTONIN/DOPAMINE INTERACTION......Page 146
Dopamine and Antidepressant Drugs......Page 147
Serotonin/Dopamine Interaction and Antidepressant Drugs......Page 148
REFERENCES......Page 153
ABSTRACT......Page 159
REFERENCES......Page 164
ABSTRACT......Page 167
INTRODUCTION......Page 168
Neurochemical Aspects of Dopamine......Page 169
Neurochemical Aspects of Nitric Oxide......Page 171
Regulation of Dopaminergic Neurotransmission by NO......Page 173
Basal Ganglia: DA and NO in the Modulation of the Striatal Complex......Page 176
NO, DA and Parkinson Disease......Page 179
Evidence of NO Involvement in Schizophrenia......Page 183
DA and NO in Attentional and Information Processing Tasks......Page 185
NO in Catalepsy......Page 188
CONCLUSION......Page 189
REFERENCES......Page 190
ABSTRACT......Page 207
2. DOPAMINE RECEPTORS – SUBTYPES AND SIGNALIZATIONCASCADES......Page 208
2.1. D1-Like Family......Page 209
3. G PROTEIN COUPLED RECEPTOR REGULATION......Page 210
4.1. Glutamate Receptors (Lurcher Mutants)......Page 211
4.2. Acetylcholine Receptors (AChE KO)......Page 213
5. REGULATION OF DOPAMINE RECEPTORS BY MOLECULESAFFECTING INTRACELLULAR SIGNALIZATION (C-FOS KO)......Page 215
6. CONCLUSION......Page 216
REFERENCES......Page 217
INDEX......Page 223