DNA Topoisomerases: Biochemistry and Molecular Biology

Content: 
Serial Editors
Page ii

Edited by
Page iii

Copyright page
Page iv

Contributors
Pages xiii-xiv

Preface
Page xv
Leroy F. Liu

DNA Topoisomerases as Targets of Therapeutics: An Overview Original Research Article
Pages 1-19
James C. Wang

Biochemistry of Bacterial Type I DNA Topoisomerases Original Research Article
Pages 21-37
Yuk-Ching Tse-Dinh

The Biochemistry and Biology of DNA Gyrase Original Research Article
Pages 39-69
Rolf Menzel, Martin Gellert

Mechanism of Catalysis by Eukaryotic DNA Topoisomerase I Original Research Article
Pages 71-82
James J. Champoux

The DNA Binding, Cleavage, and Religation Reactions of Eukaryotic Topoisomerases I and II Original Research Article
Pages 83-101
Anni H. Andersen, Jesper Q. Svejstrup, Ole Westergaard

Roles of DNA Topoisomerases in Chromosomal Replication and Segregation Original Research Article
Pages 103-134
John L. Nitiss

Roles of DNA Topoisomerases in Transcription Original Research Article
Pages 135-146
Marc Drolet, Hai-Young Wu, Leroy F. Liu

DNA Topoisomerase-Mediated Illegitimate Recombination Original Research Article
Pages 147-165
Hideo Ikeda

Cellular Regulation of Mammalian DNA Topoisomerases Original Research Article
Pages 167-189
Jaulang Hwang, Ching-Long Hwong

Structure of Eukaryotic Type I DNA Topoisomerase Original Research Article
Pages 191-200
Tao-shih Hsieh, Maxwell P. Lee, Sheryl D. Brown

Type II DNA Topoisomerase Genes Original Research Article
Pages 201-225
Wai Mun Huang

Major Advances in Antibacterial Quinolone Therapy Original Research Article
Pages 227-262
Harold C. Neu

4-Quinolones and the Physiology of DNA Gyrase Original Research Article
Pages 263-283
Karl Drlica, Barry Kreiswirth

Molecular Mechanisms of DNA Gyrase Inhibition by Quinolone Antibacterials Original Research Article
Pages 285-304
Linus L. Shen

Index
Pages 305-310