DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells

Front Matter....Pages i-xvi
Structure-Function Relationships in Alkylation Damage and Repair....Pages 1-17
The Roles of Beta- and Delta-Eliminations in the Repair of AP Sites in DNA....Pages 19-23
Imidazole Ring-Opened Purines: Occurence and Repair in Escherichia Coli and Mammalian Cells....Pages 25-36
Substrate Specificity of the Formamidopyrimidine-DNA Glycosylase of E. Coli : Repair of the Imidazole Ring-Opened Form of N-Hydroxy-2-Amino-Fluorene-Guanine Adducts in DNA....Pages 37-44
Investigation of Sequence Specificity in DNA Alkylation and Repair Using Oligodeoxynucleotide Substrates....Pages 45-59
Towards a Role for Promutagenic Lesions in Carcinogenesis....Pages 61-71
Acquisition of Resistance to Alkylating Agents by Expression of Methyltransferase Gene in Repair-Deficient Human Cells....Pages 73-81
The Mer Minus Phenotype, Patient Response to Nitrosoureas, and Protooncogene Activation in Human Glioblastomas....Pages 83-99
The Molecular Basis of Alkylating Agent Resistance in Mammalian Cells....Pages 101-108
Differential Repair of O 4 -Methylthymine and O 6 -Methylguanine in Rat and Hamster Liver....Pages 109-117
Formation of 1, N 6 -Ethenodeoxyadenosine and 3, N 4 -Ethenodeoxycytidine in DNA from Several Organs of Rats Exposed to Vinyl Chloride....Pages 119-128
The Role of O 6 -Alkylguanine in Cell Killing and Sister Chromatid Exchange Induced by Alkylating Agents....Pages 129-139
Inducible Repair in Mammalian Cells Treated with Alkylating Agents....Pages 141-148
An Update of the Mammalian UV Response: Gene Regulation and Induction of a Protective Function....Pages 149-165
The Transportation of AP Endonuclease from Cytoplasm to Nucleus in Mammalian Cells....Pages 167-169
DNA Damage and Oxygen Species....Pages 171-181
Molecular Studies of Mutagenesis using Plasmid Vectors in Xeroderma Pigmentosum Cells....Pages 183-193
Molecular Analysis of Mutations at the HPRT Locus: UV Mutation Spectra in Normal and UV-Sensitive V79 Chinese Hamster Cells....Pages 195-203
Comparison of the Mutational Specificities Exhibited by BPDE in Escherichia Coli and CHO Cells....Pages 205-210
Deoxyribonucleotide Pools, DNA Repair and Mutagenesis....Pages 211-220
Duplex-Duplex Homologous Recombination Catalysed by a Human Nuclear Extract. Involvement in Double-Strand Break Repair....Pages 221-231
Proteins from Yeast and Human Cells Specific for Model Holliday Junctions in DNA....Pages 233-243
Characterization of a Strand Transferase Activity from Human Cells....Pages 245-253
Mismatch Repair in Mammalian Cells: Approaches to the in Vitro Study of DNA Mismatch Correction Reactions....Pages 255-261
Mismatch Repair Patterns in Simian Cells Correlate with the Specificity of a Mismatch Binding Protein Isolated from Simian and HeLa Cells....Pages 263-270
DNA Excision Repair at the Nucleosome Level of Chromatin....Pages 271-294
Modulation of Activity of Human Chromatin-Associated Endonucleases on Damaged DNA by Nucleosome Structure....Pages 295-324
Relationships Between DNA Repair and Transcription in Defined DNA Sequences in Mammalian Cells....Pages 325-337
Non-Random Distribution of UV-Induced Repair in Higher-Order Chromatin Loops in Human Cells and its Relationship to Preferential Repair of Active Genes....Pages 339-348
Electron Microscopic Visualization of Chromatin Structure at Sites of DNA Excision Repair Following Ultraviolet Irradiation of Cultured Human Fibroblasts....Pages 349-364
Poly (ADP-Ribosyl) Ation Reactions and Modulation of Chromatin Structure....Pages 365-377
Variation of Nuclear ADP-Ribosyl Transferase in Rat Liver Carcinogenesis and in Synchronized HeLa Cells....Pages 379-389
DNA Repair Processes in Mutant Cells Deficient in Poly (ADP-Ribose) Synthesis....Pages 391-397
Co-Recessive Inheritance: A Model for Diseases Associated with Defective DNA Repair....Pages 399-428
Mammalian DNA Ligases and the Molecular Defect in Bloom’s Syndrome....Pages 429-438
Detection of Unique Antigenic Lesions in the Uracil DNA Glycosylase from Bloom’s Syndrome....Pages 439-459
DNA Ligase Activity in Human Cells from Normal Donors and from Patients with Bloom’s Syndrome and Fanconi’s Anemia....Pages 461-469
Processing of Photoinduced Cross-Links and Monoadducts in Human Cell DNA: Genetic and Molecular Features....Pages 471-482
Parallels Between Nucleotide Excision Repair in Human Cells and E. Coli ....Pages 483-488
Mechanisms of Resistance to Ionising Radiations: Genetic and Molecular Studies on Ataxia-Telangiectasia and Related Radiation-Sensitive Mutants....Pages 489-499
Defective DNA Synthesis and/or Repair in Amyotrophic Lateral Sclerosis....Pages 501-521
Genetic Analysis in Trichothiodystrophy Repair Deficient Cells Confirms the Occurrence of Xeroderma Pigmentosum Group D Mutation in Unrelated Patients....Pages 523-533
Chinese Hamster Cell Lines Defective in DNA Repair....Pages 535-545
Human DNA Repair and Recombination Genes....Pages 547-561
Molecular Genetic Dissection of Mammalian Excision Repair....Pages 563-574
The Cloning and Characterization of a Candidate Gene for the Correction of the Xeroderma D Defect....Pages 575-584
Characterisation of Chinese Hamster Ovary Cell Mutants Hypersensitive to DNA Damaging Agents....Pages 585-596
Oncogene Activation in Xeroderma Pigmentosum Skin Tumors....Pages 597-602
Heterogeneity in the O 6 Alkylguanine DNA Alkyltransferase (AGT) Activity of Human Peripheral Blood Lymphocytes (PBL’s)....Pages 603-618
Formation and Repair of Adducts that Lead to Cross-Links in DNA Treated with Chloroethylating Agents....Pages 619-638
Induction of Futile DNA Repair Processes by Bifunctional Intercalators....Pages 639-652
Back Matter....Pages 653-667