Diversification in Toxicology — Man and Environment: Proceedings of the 1997 EUROTOX Congress Meeting Held in Arhus, Denmark, June 25–28, 1997

Front Matter....Pages I-X
Front Matter....Pages 1-1
Molecular Basis of Halothane Hepatitis....Pages 3-17
Front Matter....Pages 19-19
Receptor -Mediated Toxicity....Pages 21-28
Front Matter....Pages 29-29
Animal Burdens versus Human Benefits — How Should the Ethical Limits be Drawn for Use of Animals as Models in Toxicology?....Pages 31-40
Behavior of Laboratory Animals under Unnatural Conditions....Pages 41-46
The Impact of Stress and Discomfort on Experimental Outcome....Pages 47-59
Priorities in the Development of Alternative Methodologies in the Pharmaceutical Industry....Pages 61-70
Development and Strategic Use of Alternative Tests in Assessing the Hazard of Chemicals....Pages 71-80
Front Matter....Pages 81-81
Soil Ecotoxicological Risk Assessment: How to Find Avenues in a Pitch Dark Labyrinth....Pages 83-96
Monitoring and Risk Assessment for Endocrine Disruptors in the Aquatic Environment: A Biomarker Approach....Pages 97-107
Front Matter....Pages 109-109
Developmental and Reproductive Toxicity of Persistent Environmental Pollutants....Pages 111-119
Effects of the In Vitro Chemical Environment During Early Embryogenesis on Subsequent Development....Pages 121-129
Influence of Hormones and Hormone Antagonists on Sexual Differentiation of the Brain....Pages 131-141
Reproductive Effects from Oestrogen Activity in Polluted Water....Pages 143-150
Effects of Chemical-Induced DNA Damage on Male Germ Cells....Pages 151-160
Front Matter....Pages 161-161
Animal Locomotor Behaviour as a Health Biomarker of Chemical Stress....Pages 164-178
Markers of Exposure to Aromatic Amines and Nitro-PAH....Pages 179-187
Hematological and Biochemical Parameters in Pollution-Exposed Mice....Pages 189-195
Front Matter....Pages 197-197
Detection of Low Levels of DNA Damage Arising from Exposure of Humans to Chemical Carcinogens....Pages 199-205
Front Matter....Pages 207-207
Natural Antioxidants in Chemoprevention....Pages 209-226
Development of In Vitro Models for Cellular and Molecular Studies in Toxicology and Chemoprevention....Pages 227-236
Front Matter....Pages 207-207
Bioavailability and Health Effects of Dietary Flavonols in Man....Pages 237-248
Epidemiological Studies on Antioxidants, Lipid Peroxidation and Atherosclerosis....Pages 249-267
Front Matter....Pages 269-269
Regulatory Immunotoxicology — The Scientist’s Point of View: An Introduction....Pages 271-274
Contact and Respiratory Allergy: A Regulatory Perspective....Pages 275-284
Immunotoxicology: Extrapolation from Animal to Man — Estimation of the Immunotoxicologic Risk Associated with TBTO Exposure....Pages 285-292
Regulating Immunotoxicity Evaluation: Issues and Needs....Pages 293-299
Front Matter....Pages 301-301
Biomarkers in Metabolic Subtyping — Relevance for Environmental Cancer Control....Pages 303-310
Assessment of Animal Tumour Promotion Data for the Human Situation....Pages 311-319
Use of Transgenic Mutational Test Systems in Risk Assessment of Carcinogens....Pages 321-330
Assessing Toxicological Impacts in Life Cycle Assessment....Pages 331-345
Front Matter....Pages 347-347
Risk Assessment for Complex Chemical Exposure in Aquatic Systems: The Problem of Estimating Interactive Effects....Pages 349-361
Exposure of Humans to Complex Chemical Mixtures: Hazard Identification and Risk Assessment....Pages 363-373
Front Matter....Pages 375-375
Peroxisome Proliferator-Activated Receptor-alpha and the Pleiotropic Responses to Peroxisome Proliferators....Pages 377-386
Excitotoxicity in the Brain....Pages 387-395
Front Matter....Pages 397-397
Variability in the Response of Daphnia Clones to Toxic Substances: Are Safety Margins Being Compromised?....Pages 399-406
Sources and Implications of Variability in Sensitivity to Chemicals for Ecotoxicological Risk Assessment....Pages 407-418
Polymorphism in Glutathione S-Transferase Loci as a Risk Factor for Common Cancers....Pages 419-428
Population Responses to Contaminant Exposure in Marine Animals: Influences of Genetic Diversity Measured as Allozyme Polymorphism....Pages 429-439
Front Matter....Pages 441-441
The Use of Transgenic Animals to Assess the Role of Metabolism in Target Organ Toxicity....Pages 443-453
Extrahepatic Cytochrome P450: Role in In Situ Toxicity and Cell-Specific Hormone Sensitivity....Pages 455-463
Front Matter....Pages 441-441
Expression of Xenobiotic-Metabolizing Cytochrome P450s in Human Pulmonary Tissues....Pages 465-469
Comparison of GST Theta Activity in Liver and Kidney of Four Species....Pages 471-474
Front Matter....Pages 475-475
Haloalkene Conjugate Toxicity: The Role of Human Renal Cysteine Conjugate C-S Lyase....Pages 477-477
Back Matter....Pages 479-482