Diffuse Low-Grade Gliomas in Adults: Natural History, Interaction with the Brain, and New Individualized Therapeutic Strategies

Front Matter....Pages i-xvii
Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Diffuse Low-Grade Gliomas....Pages 1-5
Front Matter....Pages 7-7
Epidemiology of Diffuse Low-Grade Gliomas....Pages 9-30
Histological Classification....Pages 31-44
Is Gliomatosis Cerebri a Diffuse Low-Grade Glioma?....Pages 45-59
Contribution of Molecular Biology to the Classification of Low-Grade Diffuse Glioma....Pages 61-72
Front Matter....Pages 73-73
Cellular Origin of Grade II Gliomas....Pages 75-89
Deciphering the Molecular and Cellular Basis for Dissemination of Diffuse Low-Grade Gliomas....Pages 91-98
The Molecular Biology of Diffuse Low-Grade Gliomas....Pages 99-115
Proteomic Studies in Low-Grade Gliomas: What Have They Informed About Pathophysiology?....Pages 117-136
Human Low-Grade Glioma Cultures....Pages 137-163
Animal Models for Low-Grade Gliomas....Pages 165-175
Front Matter....Pages 177-177
Clinical Presentation in Diffuse Low-Grade Gliomas....Pages 179-188
Epilepsy in Diffuse Low-Grade Gliomas....Pages 189-203
Quality of Life in Low-Grade Gliomas....Pages 205-217
Metabolic-Oncological MR Imaging of Diffuse Low-Grade Glioma: A Dynamic Approach....Pages 219-234
Positron Emission Tomography in Diffuse Low-Grade Gliomas....Pages 235-248
Dynamics of DLGG and Clinical Implications....Pages 249-262
Front Matter....Pages 263-263
Natural History and Spontaneous Prognostic Factors....Pages 265-275
Front Matter....Pages 277-277
Language and Other Cognitive Evaluations....Pages 279-299
Functional MR and Diffusion MR Imaging in Diffuse Low-Grade Gliomas....Pages 301-320
Front Matter....Pages 277-277
Magnetoencephalography, Functional Connectivity, and Neural Network Topology in Diffuse Low-Grade Gliomas....Pages 321-336
Interactions Between Diffuse Low-Grade Glioma (DLGG) and Brain Plasticity....Pages 337-356
Front Matter....Pages 357-357
Surgery for Diffuse Low-Grade Gliomas (DLGG) Oncological Considerations....Pages 359-374
Surgery for Diffuse Low-Grade Gliomas (DLGG) Functional Considerations....Pages 375-399
Chemotherapy for Diffuse Low-Grade Gliomas....Pages 401-422
Radiation Therapy for the Treatment of Diffuse Low-Grade Gliomas....Pages 423-434
New Individualized Strategies in DLGG....Pages 435-443
Front Matter....Pages 445-445
Biomathematical Modeling of DLGG Behavior....Pages 447-455
Toward the Definition of New Endpoints....Pages 457-462
Functional Rehabilitation in Patients with Diffuse Low-Grade Glioma (DLGG)....Pages 463-473
Early Detection and Management of Incidental Diffuse Low-Grade Gliomas (IDLGG): Toward a “Prophylactic Oncological Neurosurgery”....Pages 475-480
The Origins of Diffuse Low-Grade Gliomas (DLGGs): “Functional Theory” Versus “Molecular Theory”....Pages 481-491
Back Matter....Pages 493-502