Diagnosis and Therapy of Porphyrias and Lead Intoxication: International Symposium Clinical Biochemistry

Front Matter....Pages I-XXI
Front Matter....Pages 1-1
Regulation of Heme Biosynthesis in Hepatic and Erythroid Cells: A Brief Introduction to the Pathobiochemistry of Human Porphyrias....Pages 3-7
Differential Patterns of Heme and Prophyrin Biosynthesis in Liver and Kidney: Metal Ion Blockade of δ-Aminolevulinate Synthetase Introduction by Porphyrinogenic Agents....Pages 8-14
The Regulatory Function of the Mitochondrial Inner Membrane in the Overall Ferrochelatase Reaction....Pages 15-21
Permissive Effects of Hormones on the Induction of δ-Aminolevulinic Acid Synthase in Cultured Chick-Embryo Liver Cells....Pages 22-25
Front Matter....Pages 27-27
Biochemical and Clinical Transitions Between the Hereditary Hepatic Porphyrias: New Concepts....Pages 29-45
A New Approach to Porphyria....Pages 46-50
The Clinical Chemistry of Variegate Porphyria with Special Reference to the Identification of a New Plasma-Marker Porphyrin....Pages 51-65
Expression of the Gene Defects of Acute Intermittent Porphyria (AIP) and Erythropoietic Protoporphyria (EPP) in Mitogen-Stimulated Lymphocytes....Pages 66-69
Uroporphyrinogen-Synthase (Uro-S) in Erythrocytes in Acute Intermittent Porphyria (AIP)....Pages 70-75
Hereditary Coproporphyria: Demonstration of a Genetic Defect in Coproporphyrinogen Metabolism....Pages 76-81
Front Matter....Pages 83-83
A Case of Acute Intermittent Porphyria, Relapsing Acute Pancreatitis, and Unconjugated Hyperbilirubinemia (Gilbert’s Syndrome)....Pages 85-86
Acute Intermittent Porphyria; EEG Changes and Their Relationship to the Biochemical Manifestation....Pages 87-93
Family Studies of Patients with Acute Intermittent Porphyria (AIP): Neurological, Biochemical, and Genetic Investigations....Pages 94-99
The Effect of Hematin in “Inducible” Hepatic Porphyria....Pages 100-102
Therapy of Acute Intermittent Porphyria With Ovulation Inhibitors in Women....Pages 103-104
Front Matter....Pages 105-105
Clinical Observation, Diagnostics, and Therapy for Symptomatic and Hereditary Porphyria Cutanea Tarda....Pages 107-110
Uroporphyrinogen Decarboxylase (Uro-D) Defect in Erythrocytes in Chronic Hepatic Porphyrias....Pages 111-116
The Problem of Possible Etiological Factors in the Origin and Development of PCT....Pages 117-120
Incidence of Porphyria in Slovenia....Pages 121-124
Chronic Hepatic Porphyrias and the Role of Iron in These Disorders....Pages 125-126
Front Matter....Pages 105-105
Chloroquine in the Treatment of Porphyria Cutanea Tarda....Pages 127-132
Chloroquine Treatment of Porphyria Cutanea Tarda....Pages 133-135
Clinical Importance of Suburoporphyrins....Pages 136-138
Current Diagnostic Problems in the Cutaneous Porphyrias in Infancy. Presentation of Unusual Cases....Pages 139-142
Front Matter....Pages 143-143
Influence of Environmental Factors on Porphyrin Metabolism....Pages 145-150
Porphyrinogenic Action of Polyhalogenated Aromatic Compounds, With Special Reference to Porphyria and Environmental Impact....Pages 151-164
Lead Poisoning Attributable to Automobile Traffic....Pages 165-167
Neoplasms and Metabolic Disturbances of Porphyrins in Rats With Chronic Experimental Lead Poisoning....Pages 168-171
Front Matter....Pages 173-173
Time Course and Compartment Relations of Heme-Synthesis Disturbances Induced by Inorganic Lead Compounds in Humans....Pages 175-177
Urinary Porphyrin Profiles in Acute Lead Poisoning: Relation to Differentiation From Acute Intermittent Porphyria....Pages 178-184
Determination of Lead and Cadmium in Whole Blood by Electrothermal Atomic Absorption Spectroscopy....Pages 185-187
Biochemical Behavior of Delta-Aminolevulinic Acid Dehydratase During Chronic Oral Lead Poisoning in Sheep....Pages 188-190
Diagnostic Criteria of Increased Lead Absorption in Occupational Medicine....Pages 191-197
Analysis of the Diagnostically Relevant Heme Precursors (5-Aminolevulinic Acid, Coproporphyrin, and Protoporphyrin) in Lead Poisoning by Use of Thinlayer Chromatography....Pages 198-202
Comparison of Fluorometric Micromethods for Analyzing Erythrocytic Porphyrins (EP)....Pages 203-207
Front Matter....Pages 209-209
Therapy for Lead Poisoning....Pages 211-216
Subclinical Effects of a Ubiquitous Poison: Lead....Pages 217-220
Correlations Between Chronic Exposure to Lead and Excretion of Heme Precursors in Ceramics Industry Workers....Pages 221-223
Front Matter....Pages 225-225
Modification of Radiosensitivity by Porphyrins: Studies of Tumors and Other Systems....Pages 227-235
Meso-Tetra (p-Sulfophenyl) Porphine as a Potential Tumor-Localizing Agent....Pages 236-239
Front Matter....Pages 225-225
Frequency of Occurrence of Hepatocellular Carcinoma in Patients With Porphyria Cutanea Tarda in Long-term Follow-up....Pages 240-243
Organ Porphyrins in Human Circulatory Disorders and Neoplastic Disease....Pages 244-247
Front Matter....Pages 249-249
Characterization of the Defect in Heme Metabolism in Patients With Erythropoietic Protoporphyria....Pages 251-254
Biochemical and Morphologic Changes in Early Phases of Experimental Protoporphyria....Pages 255-261
Hereditary Bovine Protoporphyria, a “Total Body” Deficiency of Ferrochelatase: Some Basic Distinctions From Hypochromic Anemias....Pages 262-265
Treatment of Erythropoietic Porphyrias....Pages 266-268
Front Matter....Pages 269-269
Interactions of Porphyrins With Proteins....Pages 271-271
Hemopexin and Albumin Metabolism in Porphyria Cutanea Tarda....Pages 272-275
Photodynamic Modification of Erythrocyte Membrane Proteins Induced by Protoporphyrin....Pages 276-279
New Aspects of Hematin Excretion in Rats....Pages 280-284
Hematin Therapy in Acute Porphyria and Observations on Hemopexin....Pages 285-292
Front Matter....Pages 293-293
Das Wirken Hans Fischers für die Porphyrinforschung....Pages 295-303
Thudichum und der Purpur....Pages 304-305
Back Matter....Pages 307-310