Diabetic Nephropathy: Pathophysiology and Clinical Aspects

Front Matter ....Pages i-xvi
Front Matter ....Pages 1-1
 A Historical Overview of Diabetic Nephropathy  (Garabed Eknoyan)....Pages 3-19
 Clinical Features and Natural Course of Diabetic Nephropathy  (Peter Rossing, Marie Frimodt-Møller)....Pages 21-32
 Global, Regional, and Ethnic Differences in Diabetic Nephropathy  (Oluwatoyin I. Ameh, Ikechi G. Okpechi, Charles Agyemang, Andre P. Kengne)....Pages 33-44
 Diabetic Nephropathy in Children and Adolescents  (Petter Bjornstad)....Pages 45-64
 Renal Disease in Obesity, Metabolic Syndrome and Diabesity  (Esteban Porrini, Maruja Navarro-Díaz, Rosa Rodríguez-Rodríguez, Eduardo Salido)....Pages 65-80
Front Matter ....Pages 81-81
 Introduction to Pathogenetic Mechanisms of Diabetic Nephropathy  (Liffert Vogt, Joris J. Roelofs)....Pages 83-87
 The Genetics of Diabetic Nephropathy  (Marcus G. Pezzolesi, Andrzej S. Krolewski)....Pages 89-112
 Pathology of the Kidney in Diabetes  (Behzad Najafian, Charles E. Alpers)....Pages 113-140
Front Matter ....Pages 141-141
 The Mesangial Cell in Diabetic Nephropathy  (Tri Q. Nguyen, Roel Goldschmeding)....Pages 143-151
 The Glomerular Endothelium in Diabetic Nephropathy: Role of Heparanase  (Johan van der Vlag, Baranca Buijsers)....Pages 153-170
 The Podocyte in Diabetic Nephropathy: Recent Advances  (Gavin I. Welsh, Richard J. Coward)....Pages 171-182
 Inflammatory Processes in Diabetic Glomeruli  (Daphne H. T. IJpelaar)....Pages 183-194
Front Matter ....Pages 195-195
 Proteinuria and Tubulotoxicity  (Norberto Perico, Ariela Benigni, Giuseppe Remuzzi)....Pages 197-214
 Tubuloglomerular Communication in Diabetic Nephropathy  (Shu Wakino, Kazuhiro Hasegawa, Hiroshi Itoh)....Pages 215-226
 Mechanisms of Interstitial Fibrosis in Diabetic Nephropathy  (Ivonne Loeffler, Gunter Wolf)....Pages 227-251
Front Matter ....Pages 253-253
 Microvascular Damage and Hemodynamic Alterations in Diabetic Nephropathy  (Eliane F. E. Wenstedt, Liffert Vogt)....Pages 255-276
 Coagulation and Hemostasis in Diabetic Nephropathy  (Joris J. Roelofs)....Pages 277-291
 Renal Hemodynamics in Diabetic Kidney Disease: Relevance for Intervention  (Marco van Londen, Niek Hessels, Annebelle Michielsen, Nicolien Kasper, Gerjan Navis)....Pages 293-304
 Microvascular Complications in the Eye: Diabetic Retinopathy  (Esmeralda K. Bosma, Cornelis J. F. van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann)....Pages 305-321
Front Matter ....Pages 323-323
 Hypertension in Diabetic Kidney Disease  (Gema Ruiz-Hurtado, Luis M. Ruilope)....Pages 325-335
 Macrovascular Involvement in Diabetes: Renal Artery Stenosis  (Bert-Jan van den Born, Fouad Amraoui)....Pages 337-355
 Atherosclerosis and Diabetic Nephropathy  (Raphael Duivenvoorden)....Pages 357-372
Front Matter ....Pages 373-373
 Animal Models of Diabetic Kidney Disease  (Isabel Nguyen, Arianne van Koppen, Jaap A. Joles)....Pages 375-413
 (Clinical) Trial and Error in Diabetic Nephropathy  (Marjolein Y. A. M. Kroonen, Hiddo J. L. Heerspink, Dick de Zeeuw)....Pages 415-431
Front Matter ....Pages 433-433
 Treatment Goals in Diabetic Nephropathy  (Gerald Vervoort)....Pages 435-450
 Kidney Transplantation and Diabetic Nephropathy  (Jesper Kers, Frederike J. Bemelman)....Pages 451-467
Front Matter ....Pages 469-469
 Health Programmes in Low- and Middle-Income Countries  (Maria Pallayova, Gopesh K. Modi, Indranil Dasgupta)....Pages 471-486
 Omics in Diabetic Kidney Disease  (Massimo Papale, Francesca Conserva, Paola Pontrelli, Loreto Gesualdo)....Pages 487-513
 Future and Novel Compounds in the Treatment of Diabetic Nephropathy  (Nienke M. A. Idzerda, Michelle J. Pena, Dick de Zeeuw, Hiddo J. L. Heerspink)....Pages 515-539
Back Matter ....Pages 541-548