Developments in Analytical Methods in Pharmaceutical, Biomedical, and Forensic Sciences

Front Matter....Pages i-x
High Performance Liquid Chromatography in Drug Level Monitoring — An Overview....Pages 1-17
New Methods of Analysis and Control of Biological Fluids, Drugs and Foods....Pages 19-28
Multivariate Analysis of Chromatographic Data: A useful Tool for Drug Identification....Pages 29-36
Quantitative Evaluation with Image Processing Scanner....Pages 37-43
Combination of Computing Integrator and Personal Computer....Pages 45-49
Forensic Toxicology: General Unknown....Pages 51-54
Epidemiological Investigation and Role of the Toxicology Laboratory....Pages 55-66
Trace Element Analyses in Forensics....Pages 67-74
The Stability of 7-Nitrobenzodiazepines in Post Mortem Blood: Analytical Problems and Forensic Implications....Pages 75-82
HPLC/Fluorescence Detection of 9-Acridanones as Analytical Method for Benzodiazepines in Biological Fluids....Pages 83-91
HPLC Simultaneous Determination of 1,4 Benzodiazepines in Biological Fluids....Pages 93-97
Saliva/Plasma Ratios for Forensic Monitoring of Drug Assumption in Opiate Addicts....Pages 99-105
Determination of Morphine in Hair by Immunochemical and Gas Chromatographic Mass Spectrometric Techniques....Pages 107-114
Determination of Morphine and Other Opioids in the Hair of Heroin Addicts by RIA, HPLC and Collisional Spectroscopy....Pages 115-127
Cocaine, Benzoylecgonine and Ecgonine Methyl Ester Determinations in Post Mortem Human Urine and Blood by Gas Chromatography and Capillary Gas Chromatography after “Extrelut®” Extraction....Pages 129-141
A Rapid and Sensitive HPLC Method for Determination of Alpha Amanitin in Urine....Pages 143-146
Fatal Ketamine Abuse: Report of a Case and Analytical Determination by Gas Liquid Chromatography/Mass Spectrometry....Pages 147-153
Head-Space and Gas Chromatography-Mass Spectrometry Techniques in the Diagnosis of Lethal Poisoning with Ethyl Ester of Fluoroacetic Acid....Pages 155-160
Factors Influencing the Urinary Excretion of Phenol and Cresols....Pages 161-168
Biotransformations of a K Region Metabolite of Benzo(a)pyrene....Pages 169-181
An Integrated Gas Chromatographic-Mass Spectrometric Screening Method for Anabolic Steroid Urinary Metabolites in Man....Pages 183-190
Methoxyimino- tert -Butyldimethylsilyl Ethers as Derivatives for the Gas Chromatography-Mass Spectrometry of 3 (or 17)-Hydroxy-C 19 — and 20-Hydroxy-C 21 -Ketosteroids....Pages 191-207
Optimization of Radioreceptor Assays for Anticholinergic Drugs in Biofluids....Pages 209-216
Comparison of Automated and Manual Methods of Liquid-Solid Sample Preparation for Determination of Drugs in Plasma by HPLC/UV....Pages 217-225
Application of Liquid-Solid Extraction: Concomitant Analysis of a Cardiovascular Drug and its Metabolites in Plasma....Pages 227-232
Determination of Amitriptyline, Chlorimipramine and their Demethylated Metabolites in Plasma by Normal Phase and UV Detection....Pages 233-239
Diclofenac in Plasma Samples, a Comparison between HPLC and Capillary GLC....Pages 241-245
Application of a Solid Phase Autosampler to the HPLC Determination of Drugs and Natural Compounds in Biological Matrices....Pages 247-256
Measurement of Plasma Catecholamines — Study at Basal and during Insulin-Induced Hypoglycemia in Normal and Diabetic Subjects....Pages 257-270
Determination of Free 3-Methoxy-4-Hydroxyphenylethylene Glycol in Human Plasma and Cerebrospinal Fluid by HPLC with Electrochemical Detection....Pages 271-277
Size Exclusion HPLC Coupled to RIA in the Study of Human Chorionic Gonadotropin (hCG) in Physiological and Pathological Conditions....Pages 279-283
HPLC-RIA Determination of Urinary 2,3 Dinor — 6 Keto — Prostaglandin F1α in Humans....Pages 285-289
Comparison of Different Methodological Approaches to the Study of the Erythrocyte NA + - K + Pump....Pages 291-296
Inhibition of Chemotactic Activity of PMN by Arsenic: A Membrane Mediated Effect....Pages 297-302
In Vitro Studies on the Acetylation of Sulphamethazine by Human Whole Blood from Healthy and Diabetic Subjects....Pages 303-313
Control of Glucose and Lipid Metabolism by Gel-Forming Fiber in Diabetes: Medium Term Effects of Guar-Gum....Pages 315-319
Back Matter....Pages 321-329