Deutsche Pharmakologische Gesellschaft: Abstracts of the 19. Spring Meeting March 14–17, 1978, Mainz

Front Matter....Pages I-VII
Intestinal Absorption of Cobalt and Iron: Interaction and Subcellular Distribution....Pages 1-1
Determination of the Amount of Mucosal Transferrin in the Upper Small Intestine (Duodenum, Jejunum) of Iron Deficient Rats....Pages 1-1
Secretion of Thallous Ions from the Blood into the Gastrointestinal Tract of Rats....Pages 1-1
Correlation between the 51 CrEdta Clearance and the Secretion of Fluid and Electrolytes under the Influence of Deoxycholate (DC) in the Rat Colon....Pages 1-1
Investigations on the Intestinal Secretion of Drugs by the Isolated Mucosa of Guinea-Pig Colon....Pages 2-2
Binding of Drugs to Muscle Tissue: Drug Interactions....Pages 2-2
Probenecid Effects on Distribution and Elimination of Benzylpenicillin in the Rat....Pages 2-2
Resorption Rate of Mg and Al from Antacida Remedies — Influences on the Distribution of Electrolytes and Trace Elements....Pages 2-2
Disposition and Anticoagulant Activity of the Enantiomers of Phenprocoumon in Phenobarbital Pretreated Rats....Pages 3-3
In Vivo Studies on the Interaction between Phenprocoumon and Acetylsalicylic Acid or Phenylbutazone....Pages 3-3
Excretion of an Analogon of Clonidine Compared with Clonidine in Rats....Pages 3-3
A Universal and Sensitive Method for Gas Chromatographic Determination of Volatile Substrates and Metabolites....Pages 3-3
Drug Binding Properties of Tyrosine-Modified Human Serum Albumin....Pages 4-4
The Interaction of Intravenous and Oral Biliary Contrast Agents with Serum Albumins....Pages 4-4
Biochemical Properties of Plasma Membranes from Candidatropicalis Grown on Glucose or Hexadecane....Pages 4-4
Alterations of Lysosomes by Amphiphilic Drugs....Pages 4-4
Influence of Niclosamide and Phenprocoumone on the Level of Energy Phosphates and Selected Substrates of Glycolysis in Rat Liver....Pages 5-5
Mode of Action of Terbufibrol (INN), A New Hypolipemic Agent....Pages 5-5
Pharmacology of Terbufibrol (INN), A New Hypolipemic Agent....Pages 5-5
Premature Induction of the Decidual Reaction after Cyclophosphamide Treatment in the Rat....Pages 5-5
Effect of Steroid Sex Hormones on the Development of Early Mouse Embryos In Vitro ....Pages 6-6
Pharmacokinetics of Phenazone in the Rat — The Classical Phenazone Determination Revisited....Pages 6-6
Binding Sites with Different Affinity to Penicillins in Staphylococcal Membranes....Pages 6-6
Investigations on the Membrane Activity of Cytostatic Methyl Hydrazones....Pages 6-6
Virazole (Ribavirin) a Cytostatic Agent....Pages 7-7
Dihydrodiol Dehydrogenase: An Important Enzyme in Dihydrodiol-Epoxide Pathway — Mediated Benzo(A)Pyrene Mutagenicity....Pages 7-7
On the Role of Unspecific Carboxylesterases (EC 3.1.1.1) in the Metabolism of Acetylsalicylic Acid and Procaine....Pages 7-7
Pharmacological Characterization of Bay G 5421, A Glucosidase Inhibitor for the Treatment of Carbohydrate-Dependent Metabolic Disorders....Pages 7-7
On the Mechanism of Digitoxoside Cleavage of Digitoxin in Rat Liver....Pages 8-8
Type I- Substrate Binding and Oxidase Function of Microsomal Cytochrome P-450....Pages 8-8
Spectral Interactions with Cytochrome P-450 Produced by Xenobiotics in Isolated Adult Rat Hepatocytes....Pages 8-8
Studies on the Cytochrome P-450-Product Complexes Formed during the Metabolism of NN-Dimethylaniline....Pages 8-8
Effect of Antioxidants on Microsomal Enzymes of Rat Liver....Pages 9-9
Substrate Specificity of Rabbit Liver Monooxygenase Induced by PCBs....Pages 9-9
Straub-Phenomenon duration as a Measure of Activity of Drug-Metabolizing Liver Enzymes....Pages 9-9
The Possible Role of the Enzyme Peroxidase for the Organotropic Toxicity of Diethylstilbestrol....Pages 9-9
Influence of Mn 2+ -Ions on Adrenaline Oxidation and Lipid Peroxidation Catalysed by Rat Liver Microsomes or by Isolated Nadph-Cytochrome C Reductase....Pages 10-10
Evidence for Two Distinct Tertiary Amine Oxidases....Pages 10-10
The Metabolism of Sulpiride in the Rat....Pages 10-10
Metabolic Degradation of Clonidine....Pages 10-10
Reductive Metabolism of P-Nitrobenzoic Acid and Nitrazepam in the Isolated Perfused Rat Liver in the Presence of Ethanol....Pages 11-11
Nucleotide Kinetics in Phase II of Drug Biotransformation as Measured by 31 -P-NMR-Spectroscopy....Pages 11-11
The Effect of Conjugation on uptake and Secretion of Lipophilic Compounds by Isolated Hepatocytes....Pages 11-11
Hepatic uptake, Metabolism and Secretion of Estrone Sulphate....Pages 11-11
Studies with Isolated Liver Cells: Kinetics and Metabolism of Bromosulfophthalein (BSP)....Pages 12-12
Sensitive Radio-Assays for the Determination of Microsomal UDP-Glucuronyltransferase in Human Liver Biopsy Specimens....Pages 12-12
Effect of Insulin on UDP-Glucuronyltransferase (UDP-GT) Activity and on p-Nitrophenol (pNP) Conjugation Rate in Isolated Perfused Livers from Normal, Fasted, and Diabetic Rats....Pages 12-12
Biotransformation of 4-Dimethylaminophenol - 14 C (DMAP) in Rat Liver and Erythrocytes....Pages 12-12
Metabolism of Isothiocyanates in Rats....Pages 13-13
Conjugation of Paracetamol during Transfer Across Intestinal Mucosa of the Rat....Pages 13-13
UV-Induced Unscheduled DNA-Synthesis in Damaged Splenic Lymphocytes of the Rat....Pages 13-13
Study of Intoxications with Diethylpentenamide and Structure Elucidation of its Metabolites by GC-MS-Technique....Pages 13-13
Mass Fragmentographic Study of the Time Course of Different Drugs with Respect to the Plasma-Salivary Distribution Coefficient in Man....Pages 14-14
The Effect of 4-Dimethylaminophenol on Acid-Base Balance, Lactate, Pyruvate, Local Cerebral Blood Flow and Brain Temperature of Dogs after Acute Cyanide Poisoning....Pages 14-14
Combined Effects: Acute Toxicity of Local Anesthetics in Binary and Ternary Mixtures Among Themselves or with Epinephrine in Isobolographic Presentation....Pages 14-14
Investigation on the Kinetic Properties of a Carrier-Bound Acetylcholinesterase (E.C.3.1.1.7) in a Column....Pages 14-14
Studies on the Action of Chloramphenicol and its Analogs on 55S, 70S, and 80S Ribosomes....Pages 15-15
Diaplacental Transfer of Thiampheni Col (TAP) in Pregnant Rats during Late Organogenesis....Pages 15-15
Diaplacental Transfer and Fetal Distribution of Thiamphenicol in Early Human Pregnancy....Pages 15-15
Activities of the Unspecific Hydroxylases, Epoxide Hydrase and Glutathione S-Transferase in Human Liver Microsomes and Cytosol during Rifampicin Treatment.....Pages 15-15
The Influence of Age on Heavy-Metal-Concentrations in Human Tissue....Pages 16-16
Cadmium Content of Mushrooms....Pages 16-16
Influence of Low Cadmium-Dosages in Subacute Experiments on the Drug Metabolism on Mice....Pages 16-16
In Vivo Application of Cobalt Modifies Activity Patterns of Microsomal Monooxygenase....Pages 16-16
Behavioural Deviations in Rats Chronically Exposed to Lead at the Accepted No-Effect Level....Pages 17-17
Oxidation of Elemental Mercury by Red-Cell Enzymes....Pages 17-17
Sodium-2,3-Dimercaptopropaneslilfonate: Pharmacokinetic Data and Therapy of Mercury Poisoning....Pages 17-17
Inhibitory Effect of Chloro(Triethylphosphine) — Gold on Rat Paw Edema....Pages 17-17
Studies on the phalloidin recognizing structure of the liver cell surface....Pages 18-18
Isolation and Characterization of Contraktile Proteins from Phalloidin Insensitive As-30D Ascites Hepatoma Cells....Pages 18-18
Toxicological Studies on Gyromitrin, a Poisonous Compound in False Morels....Pages 18-18
The Influence of Fasting on the Activity of Some Hepatotoxic Agents....Pages 18-18
On the Development of Tolerance to Hepatotoxic Agents....Pages 19-19
Liver Damage by Coumarin?....Pages 19-19
Influence of Antidotes on the Paracetamol-Induced Thioether Excretion in Rats....Pages 19-19
Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes....Pages 19-19
Influence of Paraquat on Microsomal Oxygen uptake....Pages 20-20
Peroxidation of Mitochondrial Lipids of Rat Liver Following Chronic and Acute Alcohol Treatment....Pages 20-20
Influence of Diet and Xenobiotics on the Urinary Excretion of Bound Thiol Groups in Man and Rats....Pages 20-20
Differences in Binding of Nitrosamines to Cytochrom P 450. Possible Relevance for their Activation and Inactivation.....Pages 20-20
Metabolism and Subcellular Effects of Dimethylnitrosamine Incubated in Vitro with Isolated Liver Cells....Pages 21-21
Loss of Two-Stage-Control of Cell Proliferation in Rat Liver After a Single Dose of the Carcinogen Diethylnitrosamine....Pages 21-21
Alkylating and Mutagenic Effects of Allyl and Allylogenic Compounds....Pages 21-21
Alkylation of DNA and RNA by Metabolites of Vinyl Chloride and Vinyl Bromide....Pages 21-21
Pharmacokinetics of Halogenated Ethylenes....Pages 22-22
Metabolism of Halothane as a Function of Substrate Concentration in the Isolated Perfused Rat Liver Preparation....Pages 22-22
Disposition and Metabolism of [ 14 C] 1,1-Dichloroethylene after Single Oral Administration in Rats....Pages 22-22
On the Metabolic Formation of Carbon Monoxide from Trichloroethylene....Pages 22-22
Effect of Antioxidants on Irreversible Binding of CCl 4 to Proteins and Lipids in Rat Liver Microsomes Compared to Lipid Peroxidation....Pages 23-23
Application of a Bioassay for the Determination of Picogram Levels of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)....Pages 23-23
Studies on the Mechanism of Irreversible Protein-Binding of Aromatic Hydrocarbons, Mediated by Rat Liver Microsomes: Binding of 14 C-Naphthalene and 14 C-1-Naphthol....Pages 23-23
Effect of Monooxygenase Inducers on the Binding of Benzo-(A)Pyrene Metabolites to Cellular Macromolecules in Perfused Rat Lungs....Pages 23-23
Adenylate Cyclase from Guinea-Pig Brain: Studies of a Nucleotide Binding Protein....Pages 24-24
Prostaglandin-Induced cAMP Synthesis in Peripheral Nerve....Pages 24-24
The Effect of Ca and Mg Ions on the Formation of cAMP in Isoprenaline-Stimulated Resealed Rat Reticulocyte Ghosts.....Pages 24-24
Dissociation between Activity of Adenylcyclase and Density of Adrenergic β-Receptors during Maturation of Rat Erythrocytes....Pages 24-24
Solubilized Coronary Smooth Muscle Adenylylcyclase: Influence of Lipids on Adenosine Response....Pages 25-25
Soluble Adenylate Cyclase and Guanylate Cyclase in Bovine Adrenal Cortex: Activation by Sodium Nitroprusside and Nitrosamines — Inhibition by Phospholipase a and Free Fatty Acids....Pages 25-25
Purification And Characterisation Of A cGMP-Dependent Protein Kinase From Bovine Heart Muscle....Pages 25-25
Decreased Sensitivity of β-Adrenoceptors in Left Atria from Hypothyroid Rats....Pages 25-25
Adenylate Cyclase and Specificity of the Histamine H 2 -Receptor in the Gastric Mucosa of the Guinea-Pig....Pages 26-26
Histamine-Sensitive Adenylate Cyclase of Human Gastric Mucosa: A Model for H 2 Receptor Excitation....Pages 26-26
Effect of Methylxanthines on Extracellular and Intracellular 5′-Nucleotidase Activity in Isolated Fat Cells....Pages 26-26
Dihydrocaffeic Acid, a Metabolite of Bioflavonoids, as a Cofactor of Prostaglandin Synthetase....Pages 26-26
Effect of Cyclic Nucleotide Phosphodiesterase Inhibitors on Prostaglandin Biosynthesis....Pages 27-27
Prostaglandins and Cyclic AMP in Proliferating Fibroblasts....Pages 27-27
Inhibition of Prostaglandin Synthetase by 2′-[4,5-bis-(4-chlorphenyl)-oxazolyl- (2)-mercapto]-propionic acid (EMD 26 644) in Vitro and in Vivo....Pages 27-27
Release of Prostaglandin D 2 and Thromboxane B 2 from Human Thrombocytes: Radioimmunological Determination and Modification by Drugs....Pages 27-27
Effects of Drugs on the Prostaglandin Release from Macrophages in Vitro....Pages 28-28
The Effect of Prostaglandin E 1 (PGE 1 ) on the Plasma — Lymph Barrier of the Hind Limb of Rabbits and the Antagonistic Effect of Escin and Indomethacin....Pages 28-28
Pharmacological Actions of Prostacyclin (PGI 2 )....Pages 28-28
Sulprostone (CP-34,089, ZK 57 671), a Prostaglandin E 2 Analogue with Potent Antifertility Effects and Improved Selectivity for Uterine Smooth Muscles....Pages 28-28
Characterization of Cardioactive Agents using the Analysis of the Ventricular Pressure Curve during Isovolumetric Contraction....Pages 29-29
The Influence of D 600, Ouabain, and Calcium on the Post-Rest Adaptation in Guinea Pig Papillary Muscle....Pages 29-29
The Influence of Methoxy-Verapamil (D 600) on the Frequency Dependent Activation of E-C-Coupling Efficiency in Guinea Pig Atria.....Pages 29-29
The Effect Of Adriamycin On The Isometric Contraction Of Guinea-Pig Papillary Muscle. Muscle mechanics and Electrophysiology....Pages 29-29
The Effect of Anemonia Sulcata Toxin ATX II on Post-Rest Adaptation in Guinea Pig Papillary Muscle....Pages 30-30
Dexamethasone-Induced Tolerance to Cardiac Anoxia: Rôle of Muscle Glycogen Levels and Serum Insulin....Pages 30-30
The Effect of Acetylcholine and cGMP on Slow Response Action Potential and Contractile Force in Mammalian Atrial Myocardium....Pages 30-30
The Effect of Anemonia Sulcata Toxin (ATX II) on the Calcium Content and its Exchangeability in Spontaneously Beating Atria of the Guinea Pig....Pages 30-30
On the Rate of Onset and Decline of the Effects of a Tertiary and Quarternary Cholinomimetic Drug on the Contractile Force and the Action Potentials of Guinea Pig Atria....Pages 31-31
The Positive Inotropic Effect of Phenylephrine in Bovine Cardiac Muscle....Pages 31-31
Potassium Induced Loss of the Early Component of Myocardial Contraction in Presence of Nor-Adrenaline....Pages 31-31
A Second Stereospecific Effect of Propranolol on the Isometric Contraction of Ventricular Myocardium in the Presence of Catecholamines....Pages 31-31
Frequency-Force Relationship and the Cyclic AMP System — Functional Investigations in Guinea-Pig Atria....Pages 32-32
Myocardial Phosphodiesterase Activity in Different Mammalian Species....Pages 32-32
Effects of Magnesium Aspartate Hydrochloride (Mg-Asp.-HCl) on the Adrenenergic Cardiopathy Aggravated by Ephedrine....Pages 32-32
Differences in Susceptibility to Peptides between Heart and Vas Deferens of the Guinea Pig....Pages 32-32
Inhibition of Cardiac CA ++ — Dependent Myofibrillar ATP-ASE by Acetaldehyde....Pages 33-33
Affinity Partitioning of Plasmamembrane Vesicles on Digoxin Modified Sepharose....Pages 33-33
Influence of Monovalent Cations on the Ca 2+ -ATPase of Cardiac Sarcoplasmic Reticulum and its Significans of the Positive Inotrop Effect of Cardiac Glycosides....Pages 33-33
Influence of the Na-K-ATPase Activity Upon the Kinetics of Ouabain Binding to Cardiac Tissue....Pages 33-33
Kinetics of Changes in K + -, Na + - and Ca 2+ -Content in Heart Tissue in the Presence of Cardiac Glycosides....Pages 34-34
Effects of Specific 3-H-Ouabain Binding to the Cardiac Glycoside Receptor on (Na + +K + )-ATPase Activity and on Force of Contraction in Rat Heart....Pages 34-34
Pharmacokinetics of Tritiated Penta-Acetyl-GI-Toxin in Guinea Pigs....Pages 34-34
Modulation of Functional and Metabolic Ouabain Actions by Salicylate and Indomethacin....Pages 34-34
On the Specificity of Binding of Prostaglandins to Coronary Arteries — Correlation to the Biological Response....Pages 35-35
The Influence of PGE 2 on Local Myocardial Perfusion — A Comparison with Adenosine....Pages 35-35
Coronary Dilatory Action of Adenosine Analogues in the Anaesthetized and Awake Dog....Pages 35-35
Glucagon-Release Induced by Vasoactive Adenosine Derivatives in the Conscious Dog....Pages 35-35
QSAR-Studies in the Inotropic Action of Nifedipine-Derivatives....Pages 36-36
Influence of Hexobendine on the Efflux of ( 14 C)-Purine Nucleosides from Isolated Perfused Guineapig Heart....Pages 36-36
Behaviour of left ventricular dimensions in anaesthetized dogs under the influence of antianginal compounds....Pages 36-36
Activation Mechanisms in Smooth Muscle of Human Coronary Arteries and their Selective Inhibition....Pages 36-36
PRE- and Postsynaptic Stimulation of α-Adrenoceptors by B-HT 933, an Oxazoloazepine with Clonidine-Like Actions....Pages 37-37
Pharmacodynamic and Pharmacokinetic Actions of Midodrine and ST 1059....Pages 37-37
Effects of Isoprenaline on the Microcirculation in the Calf Muscles of the Rat Studied by Fluorescence Vital Microscopy....Pages 37-37
Acute Cardiopulmonary Effects of Oxprenolol or Propranolol in the Dog....Pages 37-37
 36 Chloride Efflux from Noradrenaline-Stimulated Rabbit Aorta Inhibited by Sodium Nitroprusside and Nitroglycerine.....Pages 38-38
Central Cardiovascular Effects of cGMP....Pages 38-38
Blood-Pressure, Pulse-Rate and Growth of Rats during an Eight Months Load with Increasing Amounts of Cadmium in Drinking-Water....Pages 38-38
On the Resetting of Baroreceptors....Pages 38-38
Sympathetic Vascular Tone in Spontaneously Hypertensive Rats....Pages 39-39
Differences in Circadian Rhythm of Blood Pressure in Normotensive and Hypertensive Rats....Pages 39-39
Central Serotonin Mechanisms and Cardiovascular Control in the Rat....Pages 39-39
The Central Effect of Physostigmine on Blood Pressure and Heart Rate; Possible Cholinerg Aspects of Blood Pressure Regulation....Pages 39-39
Cardiovascular Actions and Pharmacokinetics of Propranolol in the Spontaneously Hypertensive Rat....Pages 40-40
Long Term Study of the Antihypertensive Effect of Pyroxamidine (EMD 21 192) in Renal-Hypertensive Dogs....Pages 40-40
Central Hypotensive Activity as a Function of Peripheral Hypertensive Potency and Lipophilicity....Pages 40-40
The Antagonism of the Antihypertensive Action of Clonidine by Beta-Sympaticolytic Agents in the Sh-Rat....Pages 40-40
Increased Central Hypotensive and Bradycardic Activity of Clonidine after Modification of the Vertebral Artery Technique....Pages 41-41
Clonidine Withdrawal in the Rat....Pages 41-41
Inhibition of the Renin-Angiotensin-System (RAS) in Rats with Hereditary Hypothalamic Diabetes Insipidus (DI)....Pages 41-41
Influence of Propranolol on the Central Effects of Angiotensin.....Pages 41-41
Components of the Renin-Angiotensin System in Cerebrospinal Fluid (CSF) and in Periventricular Brain Tissue....Pages 42-42
Postocclusive Response of Renal Blood Flow in the Cat....Pages 42-42
Dissociation of the Vascular and Natriuretic Effects of Diuretic Agents....Pages 42-42
On the Mode of Action of Diuretics. A Study by Continuous Microperfusion of Single Loops of Henle of the Rat Kidney in Vivo....Pages 42-42
Investigations on the Renal and Biliary Excretion of Furosemide and its Metabolites in Rhesus Monkeys (Macaca mulatta)....Pages 43-43
Clinical Studies on the Effect, Mode of Action and Pharmacokinetic of Muzolimine....Pages 43-43
On the Characterization of Various Experimental Kidney Damages by Clearance Experiments on Unanesthetized Rats....Pages 43-43
Release of Endorphins from Various Tissue Extracts....Pages 43-43
Organ Distribution and Biological Activity of 125-I-Labelled LH-RH Analogues....Pages 44-44
Studies on the Mechanism of Action of the Isoprenaline-Induced Increase in Plasma Concentrations of Vasopressin in the Rat.....Pages 44-44
Specific Binding of [ 125 J] insulin to Isolated Pancreatic Islets of Rats and Its Relationship to Glucose Metabolism....Pages 44-44
Is Stimulation of Glucose Metabolism Necessary for Initiation of Insulin Release?....Pages 44-44
Influence of Sorbitol and Mannitol on the Inhibitory Effect of Alloxan on Insulin Release by Pancreatic Islets....Pages 45-45
The Insulin Releasing Potency of Tolbutamide and Glibenclamide: A Comparative Study on the Perfused Rat Pancreas....Pages 45-45
Insulin Secretion and Metabolism of Pancreatic Islets from ob/ob Mice after Thyroxine Treatment....Pages 45-45
Pharmacodynamic Effects of Lithospermum Officinale on the Metabolism of Thyroid Hormones in the Rat....Pages 45-45
Nutritional Factors Stimulating Gastric Mucosal DNA and RNA Synthesis....Pages 46-46
H-Secretion — A Driving Force in Nacl Absorption of the Guinea Pig Gallbladder....Pages 46-46
Composition and Lithogenity of Bile in Rats and Dogs after Long Term Application of Clanobutin....Pages 46-46
Effects of Polyunsaturated Fatty Acids on Gastric Secretion in Rats....Pages 46-46
Pge-Mediated Effect of Diphenolic Laxatives....Pages 47-47
Effects of Cholinergic Stimulation on Isolated Mast Cells from Rat, Guinea Pig and Man....Pages 47-47
Inhibition of Complement Activation by the Chemotactic Drug, Propamidine....Pages 47-47
Aggregation of Leukocytes by Natural and Synthetic Chemotactic Peptides....Pages 47-47
Initiation and Modulation of ECF Generation and Secretion from Human Polymorphonuclear Neutrophils X .....Pages 48-48
Inhibition of the Antiaggregatory Activity of the Vessel Wall (Rat) by Acetylsalicylic Acid....Pages 48-48
Experimental Osteoarthrosis for Pharmacological Anti-Arthrotic Compounds....Pages 48-48
Ion-Dependence of ATP-Stimulated Lysis of Chromaffin Granules....Pages 48-48
Role of Nerve Growth Factor in the Function of Sympathetic Neurons and Adrenal Medullary Cells....Pages 49-49
Changes of Dopamine-β-Hydroxylase Activity in Human Plasma during Prolonged Overactivity of the Sympathetic Nervous System in Various Diseases....Pages 49-49
Exercise Induced Changes of Catecholamines and Potassium in Plasma After Treatment with Propranolol in Dogs....Pages 49-49
The Influence of the Rate of Perfusion on the Kinetics of Neuronal uptake in the Rabbit Isolated Heart....Pages 49-49
Contribution by Neuronal and Extraneuronal Mechanisms to the Elimination of Noradrenaline from the Extracellular Space (Rabbit Aorta)....Pages 50-50
Dissociation Constants and Partition Coefficients of Sympathomimetic Amines, their Precursors and Metabolites....Pages 50-50
Uptake of 14-C-Serotonin by Human Platelets: Influence of the Time Interval after Venepuncture and of the Storage Temperature....Pages 50-50
Inhibition of Dopamine Release from Rabbit Nucleus Caudatus by Apomorphine and Bromocriptine....Pages 50-50
Effects of Halothane on the Noradrenergic Neurons of the Rat Brain Cortex....Pages 51-51
Is Histamine Involved in the Sympathomimetic Effect of Nicotine?....Pages 51-51
α-Adrenergic Receptors in Human Platelets....Pages 51-51
Effect of a New Antihypertensive Drug, Urapidil, On Pre- and Postsynaptic α-Adrenoceptors in Guinea-Pig and Rat Vas Deferens....Pages 51-51
Blocking Properties of 2-Halogeno-3′, 4′-Dihydroxy-Acetophenone Derivatives on the Alpha-Adrenergic Receptor....Pages 52-52
Further Evidence for a Selective Post-Synaptic α-Adrenoceptor Blockade with Prazosin in Vascular Smooth Muscle....Pages 52-52
β-Adrenoceptors and Adenylcyclase Activity in Erythrocytes from Rats Pretreated with Isoprenaline....Pages 52-52
Classification of Beta-Adrenoceptor Sub-Type Mediating Renin Release from the Juxtaglomerular Apparatus of the Rat....Pages 52-52
The Affinity of Carazolol for Myocardial and Tracheal β-Adrenoceptors Activated by (−)-Isoprenaline....Pages 53-53
Effects of Some Dopamine Derivatives on Lipid and Carbohydrate Metabolism....Pages 53-53
Blood Flow and Regional Sympathetic Activity in the Superior Mesenteric Vascular Bed during Injection and Continuous Infusion of Dopamine....Pages 53-53
The Influence of Reserpine and Adrenalectomy on Plasma Catecholamine Levels after Elevation of Intracranial Pressure in the Rat and in the Cat....Pages 53-53
About the Influence of Adenine Nucleotides Upon the Response of Vascular Smooth Muscle to Adrenergic Drugs....Pages 54-54
Bioisosterism in the Field of Parasympathomimetics....Pages 54-54
In Vitro and in Vivo Binding Studies on the Interactions of Psychotropics Drugs with Muscarinic Receptors....Pages 54-54
Determination of the Subcellular Origin of [ 14 C] Acetylcholine (ACh) and [ 3 H] Acetylpyrrolidinecholine (Apych) Released from Guinea-Pig Cerebral Cortex after Electrical Stimulation....Pages 54-54
Effects of Atropine on Acetylcholine Overflow from Perfused Chicken Hearts....Pages 55-55
The Effect of Anticholinergics on Four Parameters Recorded Simultaneously in Rats....Pages 55-55
Effects of Ouabain and Adenosine on Extracellular Ca 2+ and K + , as Measured with Ion Selective Microelectrodes in Cerebellar Cortex....Pages 55-55
Effects of Anesthetics on the Cellular Regulation of Energy Metabolism....Pages 55-55
Effect of Halothane on the Survival Time of Tetanus Intoxicated Mice....Pages 56-56
Antagonism of acute pyrazidol overdosage in the mouse....Pages 56-56
Interactions of Anticonvulsants and Neuroleptics in Experimental Seizures....Pages 56-56
Distribution of Valproate Across the Interface between Blood and Cerebrospinal Fluid....Pages 56-56
Pharmacokinetics of Ethosuximide in the Dog....Pages 57-57
Effect of Single and Repeated Treatment with Antidepressants on Clonidine-Induced Hypoactivity in the Rat....Pages 57-57
Substance P in Circulating Blood: Origin and Elimination....Pages 57-57
Substance P and Synaptic Vesicles: Characteristics of Binding....Pages 57-57
Inhibition of Taurine uptake into and Release from P 2 -Fractions Prepared from Kainic Acid Lesioned Rat Corpora Striata....Pages 58-58
Effects of Diazepam and Baclofen on the Gaba Turnover Rate in Various Mouse Brain Regions....Pages 58-58
Effect of Baclofen Applied to the Substantia Nigra on Striatal Levels of Dopamine, 5-HT and their Metabolites....Pages 58-58
The Anti-Nociceptive Action of Substantia Nigra Stimulation and Some of its Pharmacological Aspects....Pages 58-58
In Vivo Release of Endogenous Catecholamines and Gaba in the Hypothalamus....Pages 59-59
Studies on the Effectiveness of Dopaminergic Substances on the Experimentally Induced Muscular Rigidity of Rats....Pages 59-59
Atypical Neuroleptics: Effect on Dopamine Synthesis and Release in Rat Brain in Vivo....Pages 59-59
Inhibition of Locomotor Activity of Rats by Low Doses of Different Dopamine (DA) Receptor Agonists....Pages 59-59
The Effect of EMD 25 004 (5-methyl-3-[2-(4-phenyl-1, 2, 3, 6-tetrahydropyridyl-1)-ethyl]-pyrazole) on Central Monoaminergic Neurons....Pages 60-60
The Effects of Benzoctamine (Tacitin R ) on Reflexly Activated γ-Motoneurones of Decerebrated or Spinalized Cats....Pages 60-60
Formation of β-Carbolines: A New Metabolic Pathway of Indoles in the Brain of Rats....Pages 60-60
Extraction of Compounds with Opioid Activity from Milk....Pages 60-60
Radioimmunoassay (RIA) of β-Endorphin....Pages 61-61
Peptidase-Resistant Endogenous Ligands for the Opiate Receptors....Pages 61-61
The Release of Enkephalins from Rat Striatal Slices in Vitro ....Pages 61-61
Evidence for a Role of Endorphins in Emotional Hyperthermia....Pages 61-61
Antagonism by Opiates Against Prostaglandin E 2 -Stimulated Adenylate Cyclase in the Corpus Striatum....Pages 62-62
Quantitative Evaluation of the Morphine Abstinence Syndrome in Mice and the Influence of Some Antagonists of the Cns Transmitters on the withdrawal Signs.....Pages 62-62
Provoked and Spontaneous withdrawal in the Determination of Dependence on Morphine....Pages 62-62
Influence of Drugs on Escape Behavior Following Different Kinds of Aversive Stimuli in Rats of Different Age....Pages 62-62
Tetrahydronorharmane (THN) and 6-Hydroxy-Norharmane: Physiological Components in Platelets and Urine of Man....Pages 63-63
Increase in Sensitivity of the Fluorometric Plasma Histamine Determination: Routine Assay in the Femtomol Range....Pages 63-63
Renal Excretion of D-Glucuronic Acid Metabolites as a Measure for Microsomal Enzyme Induction....Pages 63-63
Pharmacokinetics of Fentanyl — Evaluation of an Infusion Model....Pages 63-63
A Method for Measuring Plasma Protein Binding of TRI Cyclic Psychoactive Drugs at Therapeutic Levels....Pages 64-64
Investigations on DPH Protein Binding....Pages 64-64
The Influence of Plasma Level Monitoring of Antiepileptic Drugs on Therapeutic Outcome in Epileptic Outpatients. Part 1: Study Design....Pages 64-64
The Influence DF Plasma Level Monitoring of Antiepileptic Drugs on Therapeutic Outcome in Epileptic Outpatients. Part 2: Results....Pages 64-64
Pharmacikinetics of Carbamazepine and its Active Metabolite, Carbamazepine-10,11-Epoxyd after Single and Chronic Administration in Healthy Humans....Pages 65-65
Anticoagulant Activity of the Enantiomers of Acenocoumarol in Man....Pages 65-65
Hplc-Determination of Sulfapyridine and its Metabolites in Human Plasma and its Pharmacokinetics in Man....Pages 65-65
Preoperative Haemodilution and the Action of Neuromuscular Blocking Agents....Pages 65-65
Carbonic Anhydrase Inhibitors as Broncholytic Substances....Pages 66-66
Hemodynamic Effects of Acute β-Adrenergic Blockage with Atenolol....Pages 66-66
Halothane-Induced Lipid Peroxidation in Man and Rat as Measured by Ethane Formation in Vivo....Pages 66-66
Elimination of Parathion by Hemoperfusion in Severe E 605 Forte R Intoxication in Vivo....Pages 66-66
Carbromal — a “sedative” of similar potency to barbiturates....Pages 67-67
Dependence on 2,2 Diethyl-4-Pentenamide (Diethyl-Allylacetamide, in Novo-Dolestan R , Insomnia R )....Pages 67-67
Present Drug Situation....Pages 67-67