De-Sequencing: Identity Work with Genes

Series Editors’ Preface
Contents
Notes on Contributors
List of Figures
1 Introduction
	References
Part I Science and Medicine
2 Personalised Medicine: Problems of Translation into the Human Domain
	2.1 Introduction
	2.2 The Current Status of Personalised Medicine
	2.3 A Vision of Prevention and Participation
	2.4 What Is Translation?
		2.4.1 Evidence-Based Medicine in Flux
		2.4.2 Problems of Prediction
		2.4.3 Clinical Utility: Problems of Waste and Harm
		2.4.4 Findings of Unknown Significance
		2.4.5 False Positives
		2.4.6 Overdiagnosis
		2.4.7 Vested Interests
		2.4.8 Social Level Damage
		2.4.9 Social and Cultural Iatrogenesis
	References
3 Contemporary Future Parents: From Tentative Pregnancy and Moral Pioneers to Educated Moral Gamblers
	References
Part II Philosophy of Biology
4 Developmental Narratives: How We Think that Organisms Use Genetic and Epigenetic Information
	4.1 Climbing the DNA
	4.2 Responsive Minds in Responsive Bodies
	4.3 The Concept of Epigenetics
	4.4 Organic Responsivity
	4.5 Corporeal Presence
	References
5 Epigenetics, Responsiveness and Embodiment
	5.1 Epigenetics?
	5.2 Responsiveness as Agency or Causal Process?
	5.3 Epigenetics as Reason for Responsiveness at All Levels?
	5.4 Embodiment Already in Nature–Nurture Interaction
	5.5 Summary
	References
6 Space and Time of Developmental Narratives
	References
Part III Societal Contexts
7 Data Mining in Systems Medicine and the Project of Solidarity: The Interface of Genomics and Society Revisited
	7.1 Introduction: From Genomic Medicine to Precision Medicine
	7.2 Citizens as Health Altruists: Is There a Societal Duty to Collect More Data?
	7.3 Can Genomic and Other Data Easily Be Integrated and Rendered Meaningful?
	7.4 Does Personalised Medicine Necessarily Lead to Narcissistic,  Individualistic Medicine?
	References
8 Experimenting with Solidarity in Biomedicine: From Practice to Principle?
	8.1 Moral Economies Are Unstable Systems
	8.2 The Epistemic Work Towards Interoperability and Solidarity
	8.3 Conclusions
	References
9 The Moral Making of Data-Rich Personalised Medicine
	9.1 Personalising Medicine for the ‘Common Good’?
	9.2 Individual Responsibility for Our Collective Medical Future
	References
Part IV Families
10 An Ordering of Letters: My Own Personal Genome
	10.1 100,000 Personal Genomes
	10.2 Life Stories
	10.3 Testing Times: CAG Repeats
	10.4 Another Ordering of Letters
	10.5 Life and Death Stories
	10.6 Inheriting Mistakes
	References
11 Illness in the World of the Genome
	References
12 How Personal Is the Genome? The Shadow of Genetic Predictions
	12.1 Futures
	12.2 How Personal Is the Genome?
	References
Part V Individual Experiences
13 Lived Genome Phenomenology: Exploring the Genetics of Chronic Inflammatory Bowel Diseases
	13.1 Introduction
	13.2 A Phenomenological Approach to Genomic Knowledge
	13.3 Genetics as a Relief
	13.4 Genetics and Agency
	13.5 Sense-Making as a Form of De-sequencing
	References
14 Existential Storytelling in a Genomic World
	14.1 Existential Storytelling
	14.2 Two Types of Change in Storytelling
	References
15 Sudden Evolutionary Changes in Palearctic Warblers