Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

Front Matter....Pages i-xxiv
Zinc Finger-DNA Interaction: Effect of Metal Replacement, Free Radical Generation and DNA Damage and its Relevance to Carcinogenesis....Pages 1-14
Pathways in the Chromium(VI)-Mediated Formation of DNA Lesions: A Review....Pages 15-34
Approaches to the Biological Monitoring of Chromium(VI) Exposed Individuals....Pages 35-53
The Mechanisms of Metal Carcinogenicity....Pages 55-72
The Oxidative Damage Hypothesis of Metal-Induced Genotoxicity and Carcinogenesis....Pages 73-92
Effects of Calcium, Magnesium, Zinc, and Iron on Nickel Carcinogenesis: Inhibition Versus Enhancement....Pages 93-106
Modeling the Metal Binding Sites in Core Histones: Interactions of Carcinogenic Ni(II) with the -CAIH- Motif of Histone H3....Pages 107-121
Perinatal Effects of Metals and Cancer in Offspring....Pages 123-138
Spectroscopic Properties of Ag(I), Cd(II), Cu(I), Hg(II), and Zn(II) Metallothioneins....Pages 139-194
Diversity of Cluster Structures in Mammalian Metallothionein: Interplay Between Metal Ions and Polypeptide Chain....Pages 195-215
Metallothionein in Cytotoxicity and Genotoxicity of Metals....Pages 217-229
Aluminium(III) Speciation and Biological Effects....Pages 231-240
Interaction of Al(III) with Biomolecules: Bioinorganic Chemistry and Biological Implication....Pages 241-251
Complexes of Aluminium(III) with Biologically Important Ligands....Pages 253-263
Bioinorganic Aspects of Lanthanide(III) Coordination Chemistry: Modelling the Use of Lanthanides(III) as Probes at Calcium(II) Binding Sites....Pages 265-272
From the Mass Production of Methylococcus Capsulatus to the Efficient Separation and Isolation of Methane Monooxygenase Proteins. Characterization of Novel Intermediates in Substrate Reactions of Methane Monooxygenase....Pages 273-286
Modeling Manganese Redox Enzymes....Pages 287-309
Li + Transport Properties in Perfused Neuronal Cells by 7 Li NMR Spectroscopy....Pages 311-321
Active Efflux Mechanisms for Cellular Resistance....Pages 323-347
Transferrin: A Natural Carrier for Metal Ions and Drugs....Pages 349-361
Human and Ecological Health Risks from Heavy Metals and Other Substances Released to the Environment from Metal Shredders....Pages 363-373
Analytical Applications of Vibrational Spectroscopy in Bioorganometallic Chemistry....Pages 375-388
Advanced Techniques for Bioinorganic and Environmental Speciation Analysis for Heavy Metals....Pages 389-409
A Heavy Metal Pollution in Industrial Zone and its Effect on Soil and Spring Water in Iskenderun Bay, North-East Mediterranean....Pages 411-418
Mechanistic Aspects of Pt Antitumor Chemistry....Pages 419-433
Factors Affecting Formation and Structure of DNA Intrastrand Cross-Links by Dinuclear Platinum Complexes....Pages 435-444
Tin-Based Antitumor Drugs....Pages 445-455
Ruthenium-Sulfoxide Complexes with a Specific Antimetastatic Activity....Pages 457-466
Synthesis, Spectroscopy and Structures of Complexes of PD(II) with 4N-Substituted Derivatives of 2-Acetylpyridine Thiosemicarbazone....Pages 467-476
Design of Proteins with ATCUN Motif which Specifically Cleave DNA....Pages 477-491
The Binding of Transition Metal Ions to DNA Oligonucleotides Studied by Nuclear Magnetic Resonance Spectroscopy....Pages 493-509
Pyrimidine Nucleobases as Versatile and Multidentate Ligands for Heavy Metal Ions. Significance of Metal Binding to the C(5) Sites of Uracil and Cytosine....Pages 511-520
Potentiometric and Spectroscopic Studies on the Ternary Complexes of Copper(II) and Palladium(II) with Peptides and Nucleobases....Pages 521-535
Metal Binding Selectivity of Oligopeptides....Pages 537-547
Bioinorganic Chemistry of Toxic Nickel....Pages 549-558
Interaction of Platinum(II), Palladium(II) and Mercury(II) Salts with Histidine (His) and/or Cysteine (Cys) Containing Peptides....Pages 559-578
Electrochemical and Chemical Oxidation of K(C 2 H 5 OCS 2 ), [Ni(C 2 H 5 OCS 2 )D And [N(C 2 H 5 ) 4 ][Ni(C 2 H 5 OCS 2 ) 3 ]....Pages 579-590
Transport of Biomimetic Multinuclear Complexes of Manganese into Environmental Abudant Clays....Pages 591-603
Sequential Oligopeptide Carriers (SOC n ) for Producing Potent Antigens and Effective Immunogens....Pages 605-614
Back Matter....Pages 615-629