Cytokines in Hemopoiesis, Oncology, and AIDS II

Front Matter....Pages i-li
Front Matter....Pages 1-1
Cytokine Interactions in Hematopoiesis: An Introduction and Overview....Pages 3-13
The Role of Colony-Stimulating Factors in Infection....Pages 15-18
Physicochemical and Pharmacological Characterization of Interleukin-4: Implications for Clinical Utility....Pages 19-25
Interleukin-10: An Overview....Pages 27-30
Front Matter....Pages 31-31
In Vitro Modifications Induced by Granulocyte-Macrophage Colony-Stimulating Factor in Human Long-Term Bone Marrow Cultures....Pages 33-38
The Addition of Granulocyte-Macrophage Colony-Stimulating Factor to Normal Bone Marrow Enhances Cell Cycle and Clonogenicity Irrespective of Cryopreservation....Pages 39-43
Effect of Biological Response Modifiers on Human Bone Marrow Progenitor Cells in Human Immunodeficiency Virus Infection....Pages 45-51
Plasma Erythropoietic Activity and Hemopoiesis in Murine Postnatal Ontogenesis....Pages 53-58
In Vitro Modulation of Granulocyte-Macrophage Colony-Stimulating Factor Induced Granulocyte Surface Markers by Pentoxifylline....Pages 59-64
Myeloperoxidase: Gene Demethylation and Expression in Acute Myeloid Leukemias....Pages 65-75
Transduction of Neo r Gene into Stromal Precursor Cells of Hematopoietic Microenvironment by Retroviral Gene Transfer....Pages 77-83
Cytokine Involvement in Tumor Development and Tumor Suppression....Pages 87-92
Modulation of Growth of a Xenotransplanted Human Colon Adenocarcinoma Cell Line in Nude Mice Under the Influence of Systemic Recombinant Human GM-CSF....Pages 93-98
Influence of Interleukin-3, Granulocyte—Macrophage Colony-Stimulating Factor, and Granulocyte Colony-Stimulating Factor on the Proliferation of Human and Murine Urothelial Tumor Cell Lines....Pages 99-106
Different Cytokines with Autocrine and Immunosuppressive Activities are Secreted by a Small-Cell Lung Cancer Cell Line....Pages 107-113
Effects of Recombinant Human Erythropoietin on Clonogenic Growth of Primary Human Tumor Specimens in Vitro....Pages 115-125
Growth-Modulating Effects of Interleukin-lα, Interleukin-1β, and Macrophage Colony-Stimulating Factor in Clonogenic Tumor Cells In Vitro....Pages 127-134
Effects of Interleukin-4, Interleukin-5, and Interleukin-7 on Clonogenic Growth of Primary Human Tumors In Vitro....Pages 135-143
Effects of Interleukin-6 on Soft Agar Colony Formation of Primary Solid Tumor Specimens....Pages 145-151
Chronic Lymphocytic Leukemia B Cells Express and Secrete Significant Amounts of Transforming Growth Factor-β....Pages 153-156
Front Matter....Pages 31-31
In Vitro Tumor Necrosis Factor and Interleukin-1 Production in Patients with Chronic Lymphocytic Leukemia....Pages 157-161
Effects of Tumor Necrosis Factor-α on Acute Myeloid Leukemia Cells Measured by Flow Cytometric Detection of Bromodeoxyuridine Incorporation....Pages 163-170
Mitogenic Effect of Human Stem Cell Factor Alone or in Combination with G-CSF, GM-CSF, and IL-3 on Fresh Leukemic Blasts from Patients with Stem Cell Factor Receptor-Positive Acute Myeloid Leukemia....Pages 171-178
Effect of Interleukin-3 on Human Hematopoietic Progenitor and Precursor Cells in Patients with Myelodysplastic Syndromes....Pages 179-184
Differential Response of Cytogenetically Abnormal Cell Clones in Myelodysplastic Syndromes to Cytokines in Vitro....Pages 185-193
The In Vitro Effect of Interferon-γ on Chronic Myeloid Leukemia Cells....Pages 195-203
Simultaneous Measurement of Immunophenotype and DNA Content of Bone Marrow Cells....Pages 205-209
Cytokines in Hodgkin’s Disease....Pages 211-218
The Expression Pattern of Cytokine Genes and Cytokine Receptors by Hodgkin’s Disease-Derived Cell Lines HDLM-2 and KM-H2 Resembles That of Activated T Cells....Pages 219-230
Tumor Necrosis Factor and Lymphotoxin-Induced Signal Pathways....Pages 233-238
Tumor Necrosis Factor Receptor Expression on Human Normal and Malignant B Lymphocytes: Anti-75-kDa Tumor Necrosis Factor Receptor Antibody Inhibits B-Cell Proliferation....Pages 239-246
Detection of Point Mutations Within the Macrophage Colony-Stimulating Factor Receptor Gene in Myelodysplastic Syndromes and Acute Myelomonocytic Leukemias....Pages 247-253
Interleukin-2 Activates Nuclear Factor κB Binding Activity and Autoregulates Transcriptional Activity of its Own Receptor Gene by Normal Human Monocytes Engaging Nuclear Factor κB....Pages 255-261
Interleukin-4 Downregulates Expression of c-kit mRNA and YB5.B8 Antigen (Stem Cell Factor Receptor) in Human Myeloid/Mast Cell Progenitor Cells....Pages 263-267
Biochemical Characterization and Regulation of Expression of the Binding Protein for the Granulocyte Colony-Stimulating Factor on Leukemia Cells....Pages 269-276
Tetrahydrobiopterin is a Feedback Modulator of the Interleukin-2 Receptor Complex: Manifestations and Mechanisms....Pages 277-284
Receptor Cross-Talk: Protein Kinase C Dependent Down-Modulation of the Colony-Stimulating Factor-1 Receptor upon Activation with Interferon-γ/Lipopolysaccharide....Pages 285-290
The Interleukin-2 Receptor (CD25 and p75) in Human Monocytes and Macrophages....Pages 291-296
Synergism of Hematopoietic Cytokines and Cytosine Arabinoside in the Treatment of Acute Myelogenous Leukemia: Experimental Rationales....Pages 299-311
Effects of Recombinant Human Cytokines on Cytarabine Activity in K562 Human Myeloid Leukemia Cells....Pages 313-319
Front Matter....Pages 31-31
Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Increases DNA Polymerase Activity in Acute Myeloid Leukemia Blasts In Vitro and In Vivo....Pages 321-328
Kinetic and Genetic Resistance in Acute Leukemia....Pages 329-338
Combination of Hematopoietic Growth Factors Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-1 Reduces Toxicity of Cisplatin, Carboplatin, and Azidothymidine on Normal Human and Murine Hematopoietic Progenitors....Pages 339-344
The Susceptibility of Human Leukemia Cells to Allogeneic and Autologous Lymphokine-Activated Killer Cells and Augmentation of the Susceptibility by Exposure of Target Cells to Cytotoxic Drugs In Vitro and In Vivo....Pages 345-363
CD16 Stimulation Induces Stronger Accumulation of Cytokine mRNA in Natural Killer Cells than in Non-MHC-Restricted T Lymphocytes....Pages 367-373
Influence of Chemo- and Radiotherapy on Interleukin-1 Production by Mononuclear Cells of Children with Hematological Malignancies....Pages 375-379
Pokeweed Mitogen Induction of Interleukin-2 and Interleukin-6 in Mononuclear Cells: An Alternative Approach to the Combined Phytohemagglutinin/Phorbol Myristrate Acetate Stimulation In Vitro....Pages 381-388
Immunomodulatory Activity of Hexadecylphosphocholine: Hexadecylphosphocholine-Mediated Enhancement of T-Cell Response....Pages 389-395
Long-Term Culture and Expansion of Adherent Lymphokine-Activated Killer Cells....Pages 397-404
Bomirski Ab Melanoma as a Model of Tumor-Induced Cachexia....Pages 405-408
In Vivo Effects of Interleukin-6 and Leukemia Inhibitory Factor on Thrombopoiesis in Primates....Pages 411-416
In Vivo Synergism of Interleukin-3 and Interleukin-6 on Thrombopoiesis in Primates....Pages 417-423
Front Matter....Pages 425-425
Increased Erythropoietin Response After Treatment with Cisplatin, Etoposid, and Bleomycin in Patients with Testicular Cancer....Pages 427-433
Systemic Release of Tumor Necrosis Factor Alpha in Human Allogeneic Bone Marrow Transplantation: Clinical Risk Factors, Prognostic Significance, and Therapeutic Approaches....Pages 435-442
Sequential Release of Tumor Necrosis Factor Alpha and Tumor Necrosis Factor Receptors in Complications of Human Bone Marrow Transplantation....Pages 443-448
Tumor Necrosis Factor α in the Course of Allogeneic and Autologous Bone Marrow Transplantation....Pages 449-456
Differences in Stimulated Cytokine Release Between Sleep and Sleep Deprivation....Pages 457-463
Interleukin-5 Expressing Allergen-Specific T Cells in Patients with House Dust Mite Sensitization: Analysis at a Clonal Level....Pages 465-472
Issues in the Clinical Development of Recombinant Methionyl Human Granulocyte Colony-Stimulating Factor: A Review....Pages 475-482
The Use of Recombinant Methionyl Human Granulocyte Colony-Stimulating Factor Following High-Dose Chemotherapy and Autologous Bone Marrow Transplantation....Pages 483-489
Front Matter....Pages 425-425
Erythropoietin Treatment in Allogeneic Bone Marrow Transplantation: A Prospective and Randomized Trial....Pages 635-640
In Vivo Effects of Recombinant Human Erythropoietin on Circulating CD34 + Cells of Uremic Patients....Pages 641-644
Recombinant Methionyl Human Granulocyte Colony-Stimulating Factor in High-Risk Non-Hodgkin’s Lymphoma Treated with VIM and CHOP: Preliminary Results of a Phase I/II Study....Pages 491-495
Granulocyte Colony-Stimulating Factor in the Therapy of Myeloid Leukemia....Pages 497-502
Granulocyte Colony-Stimulating Factor Corrects Neutropenia and Associated Clinical Symptoms in Children with Severe Congenital Neutropenia....Pages 503-509
Severe Reversible Renal Failure Induced by Recombinant Human Granulocyte Colony-Stimulating Factor in a Child with Chronic Acquired Agranulocytosis....Pages 511-520
In Vitro Functions of Granulocyte Colony-Stimulating Factor Induced Neutrophils....Pages 521-527
Impaired Calcium Mobilization and Abnormalities in Microfilamentous Cytoskeletal Organization in Granulocyte Colony-Stimulating Factor Induced Neutrophils from Patients with Severe Congenital Neutropenia....Pages 529-534
Clinical Evaluation of Interleukin-3....Pages 615-625
Response to Interleukin-3 Treatment in Graft Failure After Bone Marrow Transplantation....Pages 627-632
Treatment of Poor-Risk Neuroblastoma with Intensive Chemotherapy and Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor....Pages 537-543
Treatment of Relapsed Acute Myeloid Leukemia with Granulocyte-Macrophage Colony-Stimulating Factor and Intensive Chemotherapy....Pages 545-554
Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Aplastic Anemia: A Phase I/II Trial with Emphasis on Very Severe Neutropenia and Active Infection....Pages 555-563
Successful Third Bone Marrow Transplantation for Severe Aplastic Anemia: Possible In Vivo Synergism of Granulocyte—Macrophage Colony-Stimulating Factor and Erythropoietin....Pages 565-567
Stimulation of Peripheral Blood Progenitor Cells by Chemotherapy and Granulocyte-Macrophage Colony-Stimulating Factor in Lymphoproliferative Diseases....Pages 569-574
Autologous Transplantation of Blood Stem Cells Mobilized with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Subsequent to Chemotherapy for Relapsed Hodgkin’s Disease....Pages 575-579
Immunological Characterization of Blood Stem Cell Autografts Collected Under Administration of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor....Pages 581-586
Effect of Recombinant Human Granulocyte—Macrophage Colony-Stimulating Factor on Serum Levels of Soluble CD25, CD8, and CD4 in Patients with Hodgkin’s Disease in Sensitive Relapse....Pages 587-593
Migration of Neutrophils to the Oral Mucosa During Treatment with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor....Pages 595-599
Clinical Trials of Interleukin-1β....Pages 603-612
Front Matter....Pages 425-425
Interferon-α 2b in the Treatment of Chronic Myeloid Leukemia....Pages 647-660
Interferon-α 2a in the Treatment of Chronic Myeloid Leukemia: Results of the Spanish Group on Interferon-α 2a in CML....Pages 661-665
Complex Karyotype Evolution Influenced by Interferon Therapy in a Case of Ph-Positive Chronic Myeloid Leukemia....Pages 667-672
Treatment of Primary and Relapsed Angioimmunoblastic-Type T-Cell Lymphoma with Recombinant Human Interferon-α....Pages 673-676
New Aspects in the Treatment of Human Immunodeficiency Virus Related Kaposi’s Sarcoma with High-Dose Intralesional Recombinant Interferon-α 2b ....Pages 677-682
Combination of Interferon-α and Standard Chemotherapy in Advanced Malignancies....Pages 683-687
A 21-kDa Protein as Marker in the Course of Chemotherapy Combined with Cytokines: Interferon-α or Granulocyte-Macrophage Colony-Stimulating Factor....Pages 689-692
Treatment with Human Recombinant Tumor Necrosis Factor-α of Patients with Acute Myeloid Leukemia and Chronic Myeloid Leukemia in its Accelerated or Blastic Phase....Pages 693-706
Outpatient Therapy of Advanced Malignancies Using Recombinant Interleukin-2 and Recombinant Interferon-α With or Without Chemotherapy....Pages 707-712
Treatment of Metastatic Melanoma with Interferon-α and Interleukin-2: Significant Improvement with a New Dosing Schedule....Pages 713-719
Sequential Chemoimmunotherapy in the Treatment of Metastatic Melanoma....Pages 721-727
Interleukin-2 in Combination with Dacarbazine in the Treatment for Malignant Melanoma....Pages 729-735
Characterization of CD3 + and CD56 + Lymphocyte Subsets in Melanoma Patients After In Vivo Recombinant Interleukin-2 Administration....Pages 737-746
Low-Dose Subcutaneous Interleukin-2 in Human Multiple Myeloma: Current Results of a Phase I/II Pilot Study....Pages 747-755
Tolerance and Biological Activity of Bolus Administration of Increasing Doses of Glycosylated Recombinant Interleukin-2 (SR 29009) in Patients with Hematological Malignancy....Pages 757-761
Treatment of Relapsed Acute Leukemias with Systemic Recombinant Interleukin 2 (RU 49637)....Pages 763-768
Use of Recombinant Interleukin-2 (RU 49637) After Autologous Bone Marrow Transplantation in Patients with Hematological Disease: Phase I–II Study....Pages 769-774
Phase I/II Trial with Low-Dose Interleukin-2 and Interferon-Gamma in Children with High-Risk Leukemia and Non-Hodgkin’s Lymphoma After Autologous Bone Marrow Transplantation....Pages 775-782
Autologous Bone Marrow Transplantation with 10-Day-Cultured Bone Marrow Activated by Interleukin-2 in Two Patients with Acute Lymphoblastic Leukemia....Pages 783-788
Antibody Formation in Cancer Patients Treated with Recombinant Interleukin-2 Alone or in Combination with Interferon-α 2b ....Pages 789-794
Back Matter....Pages 795-800