Cytokine Knockouts

Front Matter....Pages i-xxv
The IL-2 Deficiency Syndrome....Pages 1-19
IL-7 Knockout Mice and the Generation of Lymphocytes....Pages 21-36
Lymphoid Development and Function in IL-7R-Deficient Mice....Pages 37-52
CD40 Ligand Knockout Mice....Pages 53-67
Physiological, Immunological, and Pathological Functions of Tumor Necrosis Factor (TNF) Revealed by TNF Receptor-Deficient Mice....Pages 69-87
Cooperation Between the TNF Receptors Demonstrated by TNF Receptor Knockout Mice....Pages 89-101
Immunodeficiency of Tumor Necrosis Factor and Lymphotoxin-α Double-Deficient Mice....Pages 103-118
Characterization of Lymphotoxin-α-Deficient Mice....Pages 119-127
Interleukin-1β-Deficient Mice....Pages 129-153
Functional Phenotype of Mice Deficient in the IL-1R Type I Gene....Pages 155-171
Mice Deficient in Interleukin-1β Converting Enzyme....Pages 173-188
Neutrophilia and B-Cell Plasmacytosis in Mice Lacking the Murine IL-8 Receptor Homolog....Pages 189-205
Knockouts of Interferons, Interferon Receptors and Interferon Signaling Components....Pages 207-225
IL-6 Gene Knockout Mice....Pages 227-236
IL-6 Unique Functions in Inflammation, Bone Metabolism, and B-Cell Neoplasias Revealed by Studies on IL-6-Deficient Mice....Pages 237-258
Myocardial, Hematological, and Placental Disorders Caused by Targeted Disruption of gp130, A Common Signal Transducer for IL-6 Family of Cytokines....Pages 259-285
NF-IL6 Knockout Mice....Pages 287-313
Disruption of the LIF Receptor....Pages 315-334
Phenotypes of TGFß Knockout Mice....Pages 335-368
The Transforming Growth Factor-β1 Knockout Mouse....Pages 369-400
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)-Deficient Mice....Pages 401-418
The In Vivo Role of the Receptors for IL-3, GM-CSF, and IL-5 (β c and β IL3 )....Pages 419-434
Granulocyte Colony-Stimulating Factor (G-CSF)-Deficient Mice....Pages 435-456
Reduction of Platelets and Megakaryocytes in c- mpl -Deficient Mice....Pages 457-465
Back Matter....Pages 467-482