Current Topics in Extrapyramidal Disorders

Front Matter....Pages I-X
Parkinson’s Disease: Unanswered Questions....Pages 1-5
Blood Platelets as Models for Neurons: Uses and Limitations....Pages 7-16
Changing Concepts of Nigral Dopamine System Function Within the Basal Ganglia: Relevance to Extrapyramidal Disorders....Pages 17-23
An Autoradiographic Study of the Striatofugal Fibers in the Monkey....Pages 25-31
Kinetics of L-DOPA Metabolism in the Caudate Nucleus of Cats with Ventrotegmental Lesions....Pages 33-44
Spiroperidol Binding in the Human Caudate Nucleus....Pages 45-51
Quantitative Dissection of Human Brain Areas: Relevance to Transmitter Analyses....Pages 53-67
On the Mechanism of the Antiparkinsonian Action of l-DOPA and Bromocriptine: A Theoretical and Experimental Analysis of Dopamine Receptor Sub- and Supersensitivity....Pages 69-81
Contributions of α-Adrenoreceptor Blockade to Extra-pyramidal Effects of Neuroleptic Drugs....Pages 83-93
The Decarboxylation of DOPA in the Parkinsonian Brain: In vivo Studies on an Animal Model....Pages 95-101
Metabolic Alterations in an Animal Model of Huntington’s Disease Using the 14 C-Deoxyglucose Method....Pages 103-109
Progressive Supranuclear Palsy: Clinico-Pathological and Biochemical Studies....Pages 111-128
Clinical Analysis of Akinesia....Pages 129-136
Akinetic Freezing and Trick Movements in Parkinson’s Disease....Pages 137-141
Distribution and Metabolism of the Potential Anti-Parkinson Drng Memantine in the Human....Pages 143-148
Long-Term Responses of Parkinson’s Disease to Levodopa Therapy....Pages 149-156
Monoamine Oxidase Inhibitors as Anti-Depressant Drugs and as Adjunct to L-Dopa Therapy of Parkinson’s Disease....Pages 157-161
Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man....Pages 163-172
Dopamine Metabolism in Human Brain: Effects of Monoamine Oxidase Inhibition in vitro by (—)Deprenyl and (+) and (—)Tranylcypromine....Pages 173-178
Unilateral Parkinson’s Disease and Contralateral Tardive Dyskinesia: A Unique Case with Successful Therapy That May Explain the Pathophysiology of These Two Disorders....Pages 179-185
Lecithin in Parkinson’s Disease....Pages 187-193
Is the Neurosurgical Treatment of Parkinson’s Disease Still Indicated?....Pages 195-198
Benign and Malignant Types of Parkinson’s Disease: Clinical and Patho-Physiological Characterization....Pages 199-210
Theoretical and Clinical Aspects of the Tourette Syndrome (Chronic Multiple Tic)....Pages 211-215
The Neuropathology of GABA Neurons in Extrapyramidal Disorders....Pages 217-227
The Potential of GABA-Mimetics in the Therapy of Extrapyramidal Disorders....Pages 229-238
Back Matter....Pages 239-241