Current Directions in Insulin-Like Growth Factor Research

Front Matter....Pages i-xi
Structure, Expression, and Regulation of the IGF-I Gene....Pages 1-11
Differential Regulation of IGF-I Leader Exon Transcription....Pages 13-23
Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics....Pages 25-32
Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins....Pages 33-40
Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS....Pages 41-54
Towards Identification of a Binding Site on Insulin-Like Growth Factor-II for IGF-Binding Proteins....Pages 55-61
Transcriptional and Post-Transcriptional Regulation of the Human IGF-II Gene Expression....Pages 63-71
Significant Species Differences in Local IGF-I and -II Gene Expression....Pages 73-77
Transcriptional Regulation of the Insulin Receptor Gene Promoter....Pages 79-89
The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcription Factors....Pages 91-103
Cell Cycle Control by the IGF-1 Receptor and Its Ligands....Pages 105-112
The Insulin Receptor Family....Pages 113-124
IRR: A Novel Member of the Insulin Receptor Family....Pages 125-132
Molecular Properties of Insulin/IGF-1 Hybrid Receptors 4th International Symposium on Insulin, IGFs and Their Receptors....Pages 133-144
Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid and Atypical Receptor Subtypes....Pages 145-157
Insulin Like Growth Factor 1 Receptor Signal Transduction to the Nucleus....Pages 159-168
Molecular Cloning of pp120/ ECTO-ATPase, An Endogenous Substrate of the Insulin Receptor Kinase....Pages 169-174
The Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor: Structure, Function and Differential Expression....Pages 175-188
Parental Imprinting of the Genes for IGF-II and Its Receptor....Pages 189-203
Multihormonal Regulation of IGFBP-1 Promoter Activity....Pages 205-214
Insulin-Like Growth Factor Binding Protein-1: Identification, Purification, and Regulation in Fetal and Adult Life....Pages 215-226
Rapid Regulation of Insulin-Like Growth Factor Binding Protein-1 Transcription by Insulin in Vivo and in Vitro....Pages 227-236
IGF Binding Protein-3 and the Acid-Labile Subunit: Formation of the Ternary Complex in Vitro and in Vivo ....Pages 237-244
Role of Post Translational Modifications in Modifying the Biologic Activity of Insulin Like Growth Factor Binding Proteins....Pages 245-253
Cellular Actions of Insulin-Like Growth Factor Binding Protein-3....Pages 255-266
Gene Expression of the IGF Binding Proteins During Post-Implantation Embryogenesis of the Mouse; Comparison with the Expression of IGF-I and -II and Their Receptors in Rodent and Human....Pages 267-277
Hormonal Regulation of Insulin-Like Growth Factor Binding Protein-1 Expression and the Development of Transgenic Mouse Models to Study IGFBP-1 Function....Pages 279-291
Limited Proteolysis of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) : A Physiological Mechanism in the Regulation of IGF Bioavailability....Pages 293-300
Effects of Insulin-Like Growth Factor I (IGF-I) Administrations on Serum IGF Binding Proteins (IGFBPS) in Patients with Growth Hormone Deficiency....Pages 301-309
Metabolic Effects of rhIGF-1 in Normal Human Subjects....Pages 311-318
IGFS and Muscle Differentiation....Pages 319-326
IGF-II in the Pathogenesis of Rhabdomyosarcoma: A Prototype of IGFs Involvement in Human Tumorigenesis....Pages 327-343
The Physiology and Pathophysiology of IGF-I In the Kidney....Pages 345-366
Regulation of IGFBP-4 and -5 Expression in Rat Granulosa Cells....Pages 367-376
Insulin-Like Growth Factor (IGF) Binding Protein-1 is an Antigonadotropin: Evidence that Optimal Follicle-Stimulating Hormone Action in Ovarian Granulosa Cells is Contingent upon Amplification by Endogenously-Derived IGFs....Pages 377-385
Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Proteins in the Zucker Fatty Rat: A Case for Differential Tissue Regulation....Pages 387-396
Characterization of the IGF Regulatory System in Bone....Pages 397-406
Regulation of IGF Activity in Bone....Pages 407-414
Back Matter....Pages 415-417