Current Concepts of Bone Fragility

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Basic Biomechanics of the Skeleton....Pages 3-18
Biomechanical Factors in Adaptation of Bone Structure to Function....Pages 19-33
Cellular Mechanisms Underlying the Skeleton’s Supportive Function....Pages 35-57
Front Matter....Pages 59-59
Diagnosis and Follow-up of Patients with Osteoporosis....Pages 61-66
Modern Imaging of Patients with Metabolic Bone Disease....Pages 67-73
Nuclear Medicine Applications to Metabolic Bone Disease....Pages 75-88
Quantitative Assessment of Bone: Radiologic Methods....Pages 89-101
Bone Turnover Assessment Using Bone-Specific Biochemical Markers....Pages 103-110
The Role of Bone Biopsy in Metabolic Bone Disease....Pages 111-122
Bone Microdamage: Factors That Impair Its Repair....Pages 123-146
Front Matter....Pages 147-147
Impaired Bone Strength and Fracture Patterns at Different Skeletal Sites....Pages 149-157
Fracture Patterns in Children....Pages 159-165
Cortical Porosity in Postmenopausal and Adolescent Wrist Fractures....Pages 167-172
Pathologic Fractures and Stress Fractures: A Review of Pathogenesis and Assessment....Pages 173-180
Disuse Osteoporosis: Current Status and Problems....Pages 181-194
Osteoporosis: Limitations of Strain-Related Bone Remodeling in Its Prevention....Pages 195-196
Front Matter....Pages 197-197
Congenital Osteopetrosis....Pages 199-206
Osteogenesis Imperfecta: Current Concepts....Pages 207-214
Setpoint Proposal for Osteogenesis Imperfecta....Pages 215-219
Osteogenesis Imperfecta: Orthopedic Aspects....Pages 221-225
Front Matter....Pages 197-197
Paget’s Disease of Bone (Osteitis deformans)....Pages 227-235
Paget’s Disease of Bone: Orthopedic Management....Pages 237-262
Front Matter....Pages 263-263
Bone Fragility in Osteomalacia: Mechanisms and Consequences....Pages 265-270
Drug-Induced Osteomalacia....Pages 271-278
Accelerated Cortical Bone Loss: Primary and Secondary Hyperparathyroidism....Pages 279-285
Skeletal Problems in Chronic Renal Diseases....Pages 287-294
Glucocorticoid-Induced Osteoporosis....Pages 295-309
Etiological Spectrum of Avascular Necrosis....Pages 311-317
Reversible Osteopenia: Orthopedic Aspects....Pages 319-326
Front Matter....Pages 327-327
Pathogenic Mechanisms of the Osteoporoses....Pages 329-361
Morphology of Bone Tissue Aging....Pages 363-370
Biomechanical Compensatory Mechanisms for Age-Related Changes in Cortical Bone....Pages 371-377
Hip Fracture and Cortical Bone Density in Aging African and Caucasian Populations....Pages 379-384
Hip Fracture: A Disease and an Accident....Pages 385-389
Economic and Social Burden of Osteoporosis....Pages 391-401
Involutional Osteoporosis. Critical Evaluation of Medical Treatments....Pages 403-413
Repetitive Loading to Prevent Osteoporosis in the Vertebral Column....Pages 415-428
Orthopedic Management of Osteoporosis: Effects of Nutrition and Exercise on the Skeleton....Pages 429-447
Back Matter....Pages 449-455