Current and Future Management of Brain Metastasis

Contents......Page 6
Foreword......Page 8
Introduction......Page 10
Abstract......Page 13
Surgery......Page 14
Radiation Therapy......Page 15
Steroid Therapy......Page 16
Radiosurgery......Page 17
Multimodal Treatment......Page 18
References......Page 19
Epidemiology......Page 25
Conclusions......Page 38
References......Page 39
Abstract......Page 42
Materials and Methods......Page 43
Results......Page 44
Discussion......Page 45
References......Page 49
Abstract......Page 51
Dose and Dose- Fractionation Effect Relationship for CNS Tissue......Page 52
Kinetics of Repair of Sublethal Radiation Damage......Page 55
Application of the Kinetics of Repair of Sublethal Damage to the Use of the Gamma Knife......Page 57
Discussion......Page 62
References......Page 65
Abstract......Page 67
Imaging Protocol for Brain Metastasis......Page 68
Imaging Features of Intracranial Metastases......Page 70
Imaging Pitfalls; Mimickers of Brain Metastases......Page 82
Special Consideration; Pediatric Brain Metastases......Page 83
Conclusion......Page 84
References......Page 85
Abstract......Page 86
Role of Surgical Resection with WBRT/SRS......Page 87
Surgical Resection with WBRT versus Surgical Resection with SRS......Page 90
Multiple Metastases......Page 91
References......Page 92
Abstract......Page 94
Discussion of RCTs Evaluating WBRT According to Patient Groups......Page 96
Side Effects......Page 101
New Therapeutic Approaches for WBRT......Page 104
References......Page 105
Abstract......Page 108
Whole-Brain Radiation Therapy......Page 109
Focal Brain Radiation Therapy......Page 114
Conclusion......Page 118
References......Page 119
Abstract......Page 122
Cytotoxics in Non-Small Cell Lung Cancer......Page 123
Conclusion......Page 124
References......Page 125
Abstract......Page 127
Radiosurgery plus Whole- Brain Radiation Therapy versus Whole- Brain Radiation Therapy Alone......Page 128
Radiosurgery plus WBRT versus Radiosurgery Alone......Page 129
What Does Radiosurgery Do to the Target Tissue?......Page 130
Beyond the Guidelines......Page 131
References......Page 132
Abstract......Page 135
The Consensus Process......Page 136
Review of the Literature......Page 137
References......Page 147
Introduction and Historical Background of Dose Selection......Page 151
What Is ‘Dose’ in the First Place?......Page 153
Imaging and Dose Selection for Radiosurgery......Page 154
Prescription Isodose Lines and the Importance of Conformity and Steep Dose Gradients......Page 155
Clinical Data......Page 156
Radiosurgical Dose Prescription Guidelines......Page 157
References......Page 158
Abstract......Page 160
Whole-Brain Radiation Therapy......Page 161
Stereotactic Radiosurgery......Page 162
Prognostic Factors of NSCLC with Brain Metastasis......Page 163
Radiosurgery for Small Cell Lung Cancer......Page 164
References......Page 165
Epidemiology and Prognostic Factors......Page 168
References......Page 172
Abstract......Page 175
Surgery......Page 176
Radiation Therapy......Page 177
Stereotactic Radiosurgery......Page 178
Recurrence......Page 180
Peritumoral Edema......Page 181
Adverse Effect of SRS......Page 182
Seoul National University Hospital Experience......Page 183
Conclusions......Page 185
References......Page 186
Abstract......Page 188
Role of Radiation Therapy in Control of Melanoma......Page 189
Role of Stereotactic Radiosurgery in Treatment of Melanoma......Page 192
Role of SRS in Patients Already Treated with WBRT......Page 197
Conclusions......Page 198
References......Page 199
Abstract......Page 202
Thyroid Carcinoma......Page 203
Ovarian and Endometrial Carcinoma......Page 204
Prostate Carcinoma......Page 206
Unknown Primary Cancer......Page 207
Metastatic Sarcoma......Page 209
Disclosure Statement......Page 210
References......Page 211
Abstract......Page 213
The CyberKnife Technology......Page 214
Clinical Experience......Page 216
Conclusion......Page 219
References......Page 220
Defining the Problem......Page 222
Diagnosing the Problem......Page 224
Treating the Problem......Page 225
Conclusions......Page 229
References......Page 230
Abstract......Page 233
Tumor Bed Radiosurgery Results......Page 234
Patient Selection and Technical Considerations for Tumor Bed SRS......Page 236
References......Page 238
Abstract......Page 240
WBRT Followed by SRS......Page 241
SRS Alone......Page 242
SRS Followed by WBRT......Page 243
Neurocognition with WBRT......Page 245
References......Page 246
Abstract......Page 248
Basic Principles of Radiosurgery Machines......Page 249
Gamma Knife......Page 250
Novalis System......Page 253
CyberKnife......Page 254
Comparison of Equipment......Page 256
References......Page 258
Abstract......Page 260
Surgical Resection for Large Brain Metastases......Page 261
Seoul National University Hospital Series of SRS for Large Brain Metastases......Page 262
Conclusion......Page 270
References......Page 271
Abstract......Page 273
Patients and Methods......Page 274
Results......Page 277
Discussion......Page 281
References......Page 283
Abstract......Page 285
Clinical Suspicion of Tumor Recurrence/Progression......Page 286
Workup and Diagnosis of Recurrence......Page 287
Salvage Treatment Considerations......Page 290
Salvage Therapy......Page 291
Fractionated Stereotactic Radiotherapy......Page 293
Chemotherapy......Page 294
Recommendations......Page 295
References......Page 296
Paradigm of the Past......Page 299
Paradigm of the Present......Page 305
Paradigm of the Future......Page 311
Conclusions......Page 315
References......Page 316
Author Index......Page 321
Subject Index......Page 322
Back Cover......Page 327