COVID-19: The Essentials of Prevention and Treatment

Front Matter
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Prologue
Respiratory virus and COVID-19
	Overview of respiratory viruses
	Etiology of COVID-19
	Transmission of COVID-19
Pathogenesis of COVID-19
	Contents
	Are there any special concerns on COVID-19 and its pathogenesis?
	SARS-CoV-2 infection and cardiac injury
	Other injuries
	What is the role of cytokine release storm triggered by pathogens in severe and critical cases of COVID-19?
	Invading organs and virus-induced infections
Clinical features of COVID-19
	Contents
	Clinical manifestation
	Abnormal findings of laboratory tests
	Abnormalities and features in imaging
Diagnosis of COVID-19
	Diagnosis
		Definition of suspected case
		Definition of confirmed case
		Clinical diagnosis
	Etiological test
		Respiratory tract virus detection
		Nucleic acid detection for SARS-CoV-2
		Problems and troubleshooting in PCR testing
		Antibody detection assay for SARS-CoV-2
	Severity evaluation
	Differential diagnosis
	Cases reporting procedure
	Exclusion of cases
Treatment of COVID-19
	Site of care
	General care
	Antivirals
	Glucocorticoids
	Respiratory support
		General principles
		HFNC
		Noninvasive mechanical ventilation
		Invasive mechanical ventilation
			The lung protective ventilation strategy should be strictly enforced
			FiO2 is initially set at 100%
		ECMO
		Respiratory support and respiratory therapists in the treatment of severely and critically ill patients
	Convalescent plasma therapy
	Cytokine-targeted therapy
	Venous thromboembolism prophylaxis and treatment
	Antibacterial treatment
	Standards for discontinuation of isolation and hospital discharge
Prevention and disease control of COVID-19
	Principles
	Use of personal protective equipment
		Selection of PPE
		Use of masks
		Use of gloves
		Use of goggles and protective face shields/face screens
		Use of gowns and protective clothing
		The procedure for wearing protective articles when entering and leaving the isolation ward is as follows
	Nosocomial infection control
		Collecting and processing laboratory samples of patients with suspected COVID-19
	Fangcang shelter hospitals/temporary treatment centers
	Disease control on a community level
		Use information and communication technology to get ahead of prevention and control
		Improve the effectiveness of diagnosis and treatment with information technology
		Construction of prevention and control platform
	Vaccine development
Better understanding and control of new coronavirus infection
	How to better understand the 2019 coronavirus disease
	Improving clinical management of respiratory tract virus infection and future research agenda
		Detection of respiratory tract viruses: Etiological diagnosis of lung infection and emerging infectious diseases
		Establish a respiratory tract virus research platform for clinical diagnosis and treatment
		Attach importance to rational selection and application of antiviral drugs
		Establish a comprehensive treatment platform for severe cases life support
		Develop clinical and basic research in respiratory tract virology
	The need to conduct clinical research in an orderly way
	The importance of PCCM discipline development to cope with the epidemic situation
Index
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