Corynebacterium Parvum: Applications in Experimental and Clinical Oncology

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Bacteriological Aspect of Anaerobic Corynebacteria in Relation to RES Stimulation....Pages 3-10
Acute and Chronic Toxicities in Mammal and Subhuman Primates with Inactivated Corynebacterium Suspension....Pages 11-27
Back Matter....Pages 28-31
Front Matter....Pages 33-33
The Nature of the Active Principle of Corynebacterium parvum ....Pages 35-39
Study on Soluble Substances Extracted from Corynebacterium parvum ....Pages 40-47
Results Obtained in Our Adjuvant Screening Model with Corynebacterium parvum and Corynebacterium granulosum ....Pages 48-58
Analysis of the Corynebacterium parvum Adjuvant Effects at the Cellular and Subcellular Levels....Pages 59-65
Back Matter....Pages 66-73
Front Matter....Pages 75-75
Stimulating Effect of Corynebacterium parvum and C. parvum Extract on the Macrophage Activities against Salmonella typhimurium and Listeria monocytogenes ....Pages 77-83
Antiviral Properties of Corynebacterium parvum ....Pages 84-90
The Effects of Corynebacterium parvum Suspension on the Response to Tetanus Toxoid....Pages 91-99
Back Matter....Pages 100-103
Front Matter....Pages 105-105
 In Vivo Effects of Lymphocytes Sensitized in Vitro against Tumor Cells....Pages 107-111
The Action of Local Injections of Corynebacterium parvum in Facilitating the Extravasation of Activated Lymphoid Cells....Pages 112-116
Kinetics of Proliferation of Bone-Marrow Cell Lines after Injections of Immunostimulant Bacteria....Pages 117-125
Discussion....Pages 126-131
Inhibition of Thymidine Incorporation of Tumoral YC8 Cells Cultured in Vitro by Peritoneal Macrophages Activated with Corynebacterium parvum ....Pages 132-136
A Comparative, Scanning Electron Microscope Study of the Interaction between Stimulated or Unstimulated Mouse Peritoneal Macrophages and Tumor Cells....Pages 137-144
Discussion....Pages 145-147
The Macrophage-Stimulating Properties of a Variety of Anaerobic Coryneforms....Pages 148-161
Macrophage-Stimulating Effects of Anaerobic Coryneform Bacteria in Vitro ....Pages 162-170
Discussion....Pages 171-172
Comparative Studies on the Effect of Corynebacterium parvum on Bone-Marrow Cell Colony Formation in Vitro ....Pages 173-180
Front Matter....Pages 105-105
Nonspecific Cytotoxic Activity of Peritoneal Exudate Cells against Isogenic Tumoral Cells in Animals Treated with Corynebacterium parvum ....Pages 181-186
Discussion....Pages 187-188
Front Matter....Pages 189-189
An Analysis of the Increase in Host Resistance to Isogenic Tumor Invasion in Mice by Treatment with Corynebacterium parvum ....Pages 191-199
Discussion....Pages 200-201
Effect of Inactivated Corynebacterium on Different Experimental Tumors in Mice....Pages 202-217
Results of Investigations with Corynebacterium parvum in an Experimental Animal System....Pages 218-243
Tumor-Specific Rejection Associated with Killed Corynebacterium parvum ....Pages 244-251
An Analysis of the Antitumor Effects of Corynebacterium parvum ....Pages 252-263
Discussion....Pages 264-267
Inhibition by Corynebacterium parvum of Lung-Nodule Formation by Intravenously Injected Fibrosarcoma Cells....Pages 268-275
Regression of Hamster Melanoma by Corynebacterium parvum ....Pages 276-283
 Corynebacterium granulosum -Induced Prophylaxis and Therapy of Artificial Pulmonary Metastases of Syngenic Murine Tumors....Pages 284-296
Discussion....Pages 297-297
A Possibility of Synergism between Corynebacterium parvum and Lentinan, Serotonin, or Thyroid Hormone in Potentiation of Host Resistance against Cancer....Pages 298-313
Comparative Effects of Various Strains of Corynebacterium parvum and Other Prophylactic Agents on Tumor Development in Animals....Pages 314-318
Discussion....Pages 319-326
Front Matter....Pages 327-327
A Chemotherapeutic Perspective on Clinical Trials with Corynebacterium parvum ....Pages 329-340
Action of Corynebacterium parvum on the Phagocytic Activity of the Reticuloendothelial System in Cancer Patients (Preliminary Results)....Pages 341-348
 Corynebacterium parvum: Preliminary Report of a Phase I Clinical and Immunological Study in Cancer Patients....Pages 349-366
Discussion....Pages 367-371
Front Matter....Pages 327-327
Results Obtained with Active Immunotherapy Using Corynebacteria (Corynebacterium parvum or Corynebacterium granulosum) in the Treatment of Acute Lymphoid Leukemia....Pages 372-375
Therapeutic Trial with Reticulostimulin in Patients with Ear, Nose, or Throat Cancers....Pages 376-382
The Effect of Intravenous and Intramuscular Injection of Corynebacterium parvum ....Pages 383-388
Report on 414 Cases of Human Tumors Treated with Corynebacteria....Pages 389-401
Discussion....Pages 402-410
Front Matter....Pages 411-411
 Corynebacterium parvum Outlook and Future....Pages 413-418
Closing Remarks....Pages 419-423
Back Matter....Pages 425-444