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ویرایش: [1 ed.]
نویسندگان: Aslam Ejaz (editor). Timothy M. Pawlik (editor)
سری:
ISBN (شابک) : 0323917062, 9780323917063
ناشر: Academic Press
سال نشر: 2022
تعداد صفحات: 326
[331]
زبان: English
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود)
حجم فایل: 18 Mb
در صورت تبدیل فایل کتاب Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب مدیریت معاصر سرطان متاستاتیک کولورکتال: یک رویکرد پزشکی دقیق نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
مدیریت معاصر سرطان کولورکتال متاستاتیک: یک رویکرد پزشکی دقیق، دانش فعلی را خلاصه می کند و توصیه های عملی مبتنی بر شواهد را در مورد نحوه درمان بیماران مبتلا به سرطان کولورکتال متاستاتیک ارائه می دهد. این کتاب موضوعاتی مانند تصویربرداری قبل از عمل، استفاده از نشانگرهای مولکولی در تصمیمگیریهای درمانی، درمان نئوادجوانت، متاستاز کبدی کولورکتال همزمان و رویکردهای کم تهاجمی را ارائه میکند. علاوه بر این، ایمنی درمانی، درمان های هدفمند و بقا را مورد بحث قرار می دهد. این منبع ارزشمندی برای پزشکان، محققان سرطان، انکولوژیست ها، دانشجویان فارغ التحصیل و اعضای تحقیقات زیست پزشکی است که نیاز به درک بیشتر در مورد درمان های جدید برای متاستاز سرطان کولورکتال دارند. خلاصه ای از داده های معاصر در کار و درمان بیماران مبتلا به سرطان کولورکتال متاستاتیک در مورد رویکردهای شخصی بیمار محور جدید پیرامون مدیریت چنین انواع سرطانی بحث می کند.
Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis. Summarizes contemporary data in the workup and treatment of patients with metastatic colorectal cancer Discusses novel patient-centric personalized approaches surrounding the management of such cancer types Presents evidenced-based recommendations for precision care among patients with metastatic colorectal cancer
Front Matter Front Matter Copyright Dedication References Chapter 1 Epidemiology and risk factors for metastatic colorectal disease Colorectal cancer incidence and survival Risk factors for colorectal cancer Screening guidelines Summary References Chapter 2 The tumor microenvironment of colorectal cancer liver metastases: Molecular mediators and future therapeutic targets Introduction The unique immune microenvironment of the liver Role of liver sinusoidal endothelial cells The natural killer cells of the liver Liver dendritic cell functions Neutrophils opposing roles in liver metastasis progression Myeloid-derived suppressor cells \(MDSCs\) promote liver metasasis by diverse mechanisms Role of hepatic stellate cells Multiple factors combine to inhibit a cytolytic T cell response to metastatic cancer cells The extracellular matrix regulates cancer cell survival and growth in the liver The unique extracellular matric \(ECM\) of the liver and liver metastases The ECM and cell adhesion molecules The effect of ECM stiffness Potential strategies for targeting the microenvironment of CRLM and increasing immunotherapy efficacy in patients Conclusion Acknowledgements References Chapter 3 Pre-operative imaging, response evaluation, and surgical planning ^^e2^^80^^93 CT, PET, radiomics, and FLR measurement Introduction Role of imaging in CRLM Pre-operative imaging of CRLMs Initial staging Ultrasonography \(US\) Computed tomagraphy \(CT\) Magnetic resonance imaging \(MRI\) Fluorodeoxyglucose-positron emission tomography \(FDG-PET\) Assessment of prognosis and surgical candidacy Use of imaging for surgical planning Pre-operative treatment and response evaluation of CRLM Downsizing of initially unresectable lesions Increasing future remnant liver volume and volumetric assessment Volumetric assessment Increasing future remnant liver volume Alternative therapies for CRLM Ablation Hepatic artery infusion \(HAI\) and selective internal radiation therapy \(SIRT\) Conclusion Bibliography Chapter 4 Use of molecular markers and other personalized factors in treatment decisions for metastatic colorectal cancer Introduction Prognostic versus predictive Disease characteristics Histology Pharmacogenetics for conventional cytotoxic chemotherapy KRAS BRAF HER2 DNA microsatellite instability and immunotherapy Tumor sidedness Circulating tumor cells and cell free DNA Gut microbiome Conclusions References Chapter 5 Role of Neoadjuvant therapy in the treatment of patients with colorectal liver metastases Introduction Rationale for perioperative chemotherapy for colorectal liver metastases Preoperative chemotherapy for patients with unresectable liver metastases Neoadjuvant chemotherapy for resectable liver metastases Safety of neoadjuvant chemotherapy for colorectal liver metastases Conclusions References Chapter 6 Management of the disappeared colorectal liver metastasis Introduction Defining disappearing colorectal liver metastasis \(DLM\) Predictors of DLM pathologic response Intra-Operative evaluation of DLM Surgical resection versus surveillance of DLM Summary References Chapter 7 Approach to small liver remnant ^^e2^^80^^93 strategies to increase resectability Introduction Future liver remnant \(FLR\) Calculating FLR Optimal future liver volume Portal vein embolization \(PVE\) Indications and contraindications for PVE Portal vein ligation, a historical perspective Technical aspects of PVE Post-PVE hypertrophy/kinetic growth rate Combined portal vein & hepatic vein embolization Associating liver partition and portal vein ligation Conclusion References Chapter 8 Two-stage versus ALPPS for large intrahepatic burden of colorectal liver metastasis FLR hypertrophy and feasibility to complete both stages Morbidity and Mortality Oncological results Conclusion References Chapter 9 Synchronous colorectal liver metastasis ^^e2^^80^^93 simultaneous vs. staged approach Introduction Sequencing of care for sCRLM Perioperative chemotherapy Simultaneous approach Staged approaches: primary-first Staged approaches: liver-first Surgical approach summary MSK approach Case-based learning References Chapter 10 Minimally invasive approaches to colorectal liver metastases Introduction Laparoscopic liver resection Background Outcomes Robotic liver resection Background Outcomes Laparoscopic radiofrequency ablation Background Outcomes Laparoscopic microwave coagulation Background Outcomes Conclusion References Chapter 11 Hepatic resection of colorectal liver metastasis in the presence of extrahepatic disease Incidence of extrahepatic disease Diagnosis of extrahepatic disease Role of surgery in patients with extrahepatic disease Recurrence Lung metastases Lymph node metastases Peritoneal metastases Conclusions References Chapter 12 Locoregional approaches to colorectal liver metastasis ^^e2^^80^^93 ablation Introduction Indications and contraindications Radiofrequency vs microwave ablations Ablation approaches Post-ablation complications Surveillance Local recurrence rates Long-term outcomes Long-term outcomes of the multi-modality treatments Summary points Disclosure statement References Chapter 13 Locoregional approaches to colorectal liver metastasis ^^e2^^80^^93 intra-arterial Introduction Embolic therapies Indications and outcomes Summary of embolic therapies Transarterial radioembolization \(TARE\) Hepatic artery infusion chemotherapy \(HAIC\) HAIP: function and insertion Indications, contraindications, and other complications Summary of hepatic arterial infusion chemotherapy HAIC outcomes relative to other intra-arterial therapies Conclusions Case stem References Chapter 14 Locoregional Approaches to Colorectal Liver Metastasis ^^e2^^80^^93 Radiation Options Introduction: external beam radiation therapy \(EBRT\) for colorectal liver metastases External beam radiation: rationale for ablative dosing External beam radiation: patient selection External beam radiation: treatment planning considerations External beam radiation: target volume design and treatment objectives External beam radiation: outcomes and surveillance considerations Future directions References Chapter 15 Immunotherapy and targeted therapies for colorectal liver metastasis Targeted therapy in CRC with CLM Resectable CLM at diagnosis with no extra-hepatic metastatic disease Unresectable CLM at diagnosis with a potential for resection with no extra-hepatic metastatic disease CLM with no potential for resection and/or unresectable extra-hepatic disease First-line therapy- in combination with chemotherapy Subsequent lines of therapy Immunotherapy References Chapter 16 Adjuvant therapy following resection of colorectal liver metastases Introduction Timing of systemic treatment Role of adjuvant treatment Adjuvant intra-arterial chemotherapy following resection of colorectal liver metastases Conclusion Clinical case References Chapter 17 Long-term prognosis and surveillance of patients with resected colorectal liver metastasis Introduction Clinical risk scores Other prognostic tools Inflammatory and immune predictors of survival Predicting recurrence Surveillance and recurrence Conclusion References Chapter 18 Management of secondary recurrence of intra-hepatic colorectal liver metastasis following initial hepatic resection Introduction Surveillance following initial hepatectomy Frequency of testing Length of surveillance Testing parameters Repeat liver resection Technical considerations Published experience with repeat hepatectomy Early recurrence Other treatment modalities Systemic therapy Ablation therapy Ablative radiation Transarterial chemoembolization \(TACE\) Transarterial radioembolization \(TARE\) Hepatic artery infusion chemotherapy \(HAIC\) Transplant References Chapter 19 Colorectal liver metastasis: survivorship Introduction What is a cancer survivor? Colorectal cancer survivors with liver metastases Surveillance for recurrence and screening for second primary cancers Prognosis Disparities in metastatic colorectal cancer survival Surveillance and screening Assessment and management of physical and psychosocial effects of colorectal cancer and treatment Methods of assessment Post-Diagnosis pain Fatigue and physical activity Mood/Mental health/depression/fear Bowel function Ostomy-Specific concerns Sexual wellness Financial burden Specific HRQoL outcomes in patients with colorectal cancer liver metastases Routine health promotion needs Coordination of care among specialists and primary care clinicians Experience with healthcare providers Progressive disease Palliative care involvement Limitations and future directions Surveillance for recurrence and screening for second primary cancers Assessment and management of physical and psychosocial effects of colorectal cancer and treatment Coordination of care among specialists and primary care clinicians Summary References Contents Contributors Index