Constitutive Activity in Receptors and Other Proteins, Part B

Content: 
Series Editors
Page ii

Copyright
Page iv

Contributors
Pages xv-xxii

Preface
Page xxiii
P. Michael Conn

Contents of Previous Volumes
Pages xxv-liii

Chapter One - Identification and Characterization of Steroidogenic Factor-1 Inverse Agonists
Pages 3-23
Mabrouka Doghman, Franck Madoux, Peter Hodder, Enzo Lalli

Chapter Two - Assessment of Inverse Agonism for the Angiotensin II Type 1 Receptor
Pages 25-35
Hiroshi Akazawa, Noritaka Yasuda, Shin-ichiro Miura, Issei Komuro

Chapter Three - Measurement of Inverse Agonism in ОІ-Adrenoceptors
Pages 37-60
Carlos A. Taira, Federico Monczor, Christian Höcht

Chapter Four - Techniques for Studying Inverse Agonist Activity of Antidepressants at Recombinant Nonedited 5-HT2C-INI Receptor and Native Neuronal 5-HT2C Receptors
Pages 61-79
Mathieu Seimandi, JoГ«l Bockaert, Philippe Marin

Chapter Five - Differential Inverse Agonism at the Human Muscarinic M3 Receptor
Pages 81-101
Paola Casarosa, Tobias Kiechle, Remko A. Bakker

Chapter Six - Ghrelin Receptor: High Constitutive Activity and Methods for Developing Inverse Agonists
Pages 103-121
Sylvia Els, Annette G. Beck-Sickinger, Constance Chollet

Chapter Seven - Constitutive Activity and Inverse Agonism at the О±1a and О±1b Adrenergic Receptor Subtypes
Pages 123-138
Susanna Cotecchia

Chapter Eight - Measurement of Inverse Agonism of the Cannabinoid Receptors
Pages 139-145
Tung M. Fong

Chapter Nine - Constitutively Active Thyrotropin and Thyrotropin-Releasing Hormone Receptors and Their Inverse Agonists
Pages 147-160
Susanne Neumann, Bruce M. Raaka, Marvin C. Gershengorn

Chapter Ten - Inverse Agonists and Antagonists of Retinoid Receptors
Pages 161-195
William Bourguet, Angel R. de Lera, Hinrich Gronemeyer

Chapter Eleven - Оі-Aminobutyric Acid Type A (GABAA) Receptor Subtype Inverse Agonists as Therapeutic Agents in Cognition
Pages 197-211
Guerrini Gabriella, Ciciani Giovanna

Chapter Twelve - Assays for Inverse Agonists in the Visual System
Pages 213-224
Masahiro Kono

Chapter Thirteen - Receptor-Driven Identification of Novel Human A3 Adenosine Receptor Antagonists as Potential Therapeutic Agents
Pages 225-244
Silvia Paoletta, Stephanie Federico, Giampiero Spalluto, Stefano Moro

Chapter Fourteen - Inverse Agonist Activity of Steroidogenic Factor SF-1
Pages 245-259
Fabrice Piu, Andria L. Del Tredici

Chapter Fifteen - Methods to Measure G-Protein-Coupled Receptor Activity for the Identification of Inverse Agonists
Pages 261-273
Gabriel Barreda-GГіmez, M. Teresa Giralt, Rafael RodrГ­guez-Puertas

Chapter Sixteen - Use of Pharmacoperones to Reveal GPCR Structural Changes Associated with Constitutive Activation and Trafficking
Pages 277-292
Jo Ann Janovick, P. Michael Conn

Chapter Seventeen - Application of Large-Scale Transient Transfection to Cell-Based Functional Assays for Ion Channels and GPCRs
Pages 293-309
Jun Chen, Sujatha Gopalakrishnan, Marc R. Lake, Bruce R. Bianchi, John Locklear, Regina M. Reilly

Chapter Eighteen - Quantification of RNA Editing of the Serotonin 2C Receptor (5-HT2CR) Ex Vivo
Pages 311-328
Maria Fe Lanfranco, Noelle C. Anastasio, Patricia K. Seitz, Kathryn A. Cunningham

Chapter Nineteen - Strategies for Isolating Constitutively Active and Dominant-Negative Pheromone Receptor Mutants in Yeast
Pages 329-348
Mercedes Dosil, James B. Konopka

Chapter Twenty - Development of a GPR23 Cell-Based ОІ-Lactamase Reporter Assay
Pages 349-368
Paul H. Lee, Bonnie J. Hanson

Chapter Twenty-One - Computational Modeling of Constitutively Active Mutants of GPCRs: C5a Receptor
Pages 369-391
Gregory V. Nikiforovich, Thomas J. Baranski

Chapter Twenty-Two - TSH Receptor Monoclonal Antibodies with Agonist, Antagonist, and Inverse Agonist Activities
Pages 393-420
Jane Sanders, Ricardo NГєГ±ez Miguel, Jadwiga Furmaniak, Bernard Rees Smith

Chapter Twenty-Three - Current Standards, Variations, and Pitfalls for the Determination of Constitutive TSHR Activity In Vitro
Pages 421-436
Sandra Mueller, Holger Jaeschke, Ralf Paschke

Chapter Twenty-Four - Toward the Rational Design of Constitutively Active KCa3.1 Mutant Channels
Pages 437-457
Line Garneau, HГ©lГЁne Klein, Lucie Parent, RГ©my SauvГ©

Chapter Twenty-Five - Fusion Proteins as Model Systems for the Analysis of Constitutive GPCR Activity
Pages 459-480
Erich H. Schneider, Roland Seifert

Chapter Twenty-Six - Screening for Novel Constitutively Active CXCR2 Mutants and Their Cellular Effects
Pages 481-497
Giljun Park, Tom Masi, Chang K. Choi, Heejung Kim, Jeffrey M. Becker, Tim E. Sparer

Chapter Twenty-Seven - A Method for Parallel Solid-Phase Synthesis of Iodinated Analogs of the Cannabinoid Receptor Type I (CB1) Inverse Agonist Rimonabant
Pages 499-525
Alan C. Spivey, Chih-Chung Tseng

Chapter Twenty-Eight - Coexpression Systems as Models for the Analysis of Constitutive GPCR Activity
Pages 527-557
Erich H. Schneider, Roland Seifert

Chapter Twenty-Nine - Modeling and Simulation of Inverse Agonism Dynamics
Pages 559-582
L.J. Bridge

Chapter Thirty - Design and Use of Constitutively Active STAT5 Constructs
Pages 583-596
Michael A. Farrar

Chapter Thirty-One - In Vitro and In Vivo Assays of Protein Kinase CK2 Activity
Pages 597-610
Renaud Prudent, CГ©line F. Sautel, Virginie Moucadel, BГ©atrice Laudet, Odile Filhol, Claude Cochet

Author Index
Pages 611-637

Subject Index
Pages 639-652