Computational Neuroscience in Epilepsy

Cover......Page 1
Computational Neuroscience in Epilepsy......Page 4
ISBN 978-0-12-373649-9......Page 5
Contents......Page 6
Contributors......Page 10
Foreword......Page 14
Introduction......Page 16
PART I: Computational Modeling Techniques and Databases in Epilepsy Research......Page 22
Simulation of Large Networks: Technique and Progress......Page 24
The NEURON Simulation Environment in Epilepsy Research......Page 39
The CoCoDat Database: Systematically Organizing and Selecting Quantitative Data on Single Neurons and Microcircuitry......Page 55
Validating Models of Epilepsy......Page 64
Using neuroConstruct to Develop and Modify Biologically Detailed 3D Neuronal Network Models in Health and Disease......Page 69
Computational Neuroanatomy of the Rat Hippocampus: Implications and Applications to Epilepsy......Page 92
PART II: Epilepsy and Altered Network Topology......Page 108
Modeling Circuit Alterations in Epilepsy: A Focus on Mossy Cell Loss and Mossy Fiber Sprouting in the Dentate Gyrus......Page 110
Functional Consequences of Transformed Network Topology in Hippocampal Sclerosis......Page 133
Multiple-Scale Hierarchical Connectivity of Cortical Networks Limits the Spread of Activity......Page 153
PART III: Destabilizationof Neuronal Networks......Page 162
Computer Simulations of Sodium Channel Mutations that Cause Generalized Epilepsy with Febrile Seizures Plus......Page 164
Gain Modulation and Stability in Neural Networks......Page 176
Neocortical Epileptiform Activity in Neuronal Models with Biophysically Realistic Ion Channels......Page 189
Corticothalamic Feedback: A Key to Explain Absence Seizures......Page 205
Mechanisms of Graded Persistent Activity: Implications for Epilepsy......Page 236
Small Networks, Large Networks, Experiment and Theory – Can We Bring Them Together with Oscillations, Heterogeneity and Inhibition?......Page 253
PART IV: Homeostasis and Epilepsy......Page 266
Stability and Plasticity in Neuronal and Network Dynamics......Page 268
Homeostatic Plasticity and Post-Traumatic Epileptogenesis......Page 280
PART V: Mechanisms of Synchronization......Page 300
Synchronization in Hybrid Neuronal Networks......Page 302
Complex Synaptic Dynamics of GABAergic Networks of the Hippocampus......Page 309
Experimental and Theoretical Analyses of Synchrony in Feedforward Networks......Page 325
Modulation of Synchrony by Interneurons: Insights from Attentional Modulation of Responses in the Visual Cortex......Page 338
PART VI: Interictal to Ictal Transitions......Page 354
Cellular and Network Mechanisms of Oscillations Preceding and Perhaps Initiating Epileptic Discharges......Page 356
Transition to Ictal Activity in Temporal Lobe Epilepsy: Insights from Macroscopic Models......Page 377
Unified Modeling and Analysis of Primary Generalized Seizures......Page 408
A Neuronal Network Model of Corticothalamic Oscillations: The Emergence of Epileptiform Absence Seizures......Page 424
Extracellular Potassium Dynamics and Epileptogenesis......Page 440
Slow Waves Associated with Seizure Activity......Page 461
PART VII: Seizure Dynamics......Page 476
Dynamics of Epileptic Seizures during Evolution and Propagation......Page 478
Are Correlation Dimension and Lyapunov Exponents Useful Tools for Prediction of Epileptic Seizures?......Page 492
Towards a Dynamics of Seizure Mechanics......Page 517
PART VIII: Towards Computer-AidedTherapy......Page 534
Principles and Practice of Computer-Aided Drug Design as Applied to the Discovery of Antiepileptic Agents......Page 536
Computation Applied to Clinical Epilepsy and Antiepileptic Devices......Page 551
Microelectrode-based Epilepsy Therapy: A Hybrid Neural Prosthesis Incorporating Seizure Prediction and Intervention with Biomimetic Maintenance of Normal Hippocampal Function......Page 580
Index......Page 608
Plates......Page 626