Complement

Front Matter....Pages I-VI
Introduction and Overview....Pages 1-6
Front Matter....Pages 7-7
Structure and Expression of the C3 Gene....Pages 9-37
Molecular Genetics of the Major Histocompatibility Linked Complement Genes....Pages 39-48
The β -Cys- γ -Glu Thiolester Bond in Human C3, C4, and α 2 -Macroglobulin....Pages 49-72
Structure and Function of the Anaphylatoxins....Pages 73-99
The Human C3b Receptor....Pages 101-114
The Chemistry and Biology of Complement Receptors....Pages 115-143
Front Matter....Pages 145-145
Initiation of Complement Activation....Pages 147-166
The First Component of Human Complement (C1): Activation and Control....Pages 167-184
The Alternative Pathway of Complement....Pages 185-214
The Role of Antibody in the Activation of the Alternative Complement Pathway....Pages 215-225
The Membrane Attack Complex....Pages 227-275
Front Matter....Pages 277-277
Synthesis of Complement by Macrophages and Modulation of Their Functions Through Complement Activation....Pages 279-322
Regulation of Immune Response by Components of the Complement Cascade and Their Activated Fragments....Pages 323-344
Complement, Viruses, and Virus-Infected Cells....Pages 345-365
The Role of Complement in Host Resistance to Bacteria....Pages 367-378
Relationships Among the Complement, Kinin, Coagulation, and Fibrinolytic Systems....Pages 379-406
Front Matter....Pages 407-407
Inherited Deficiencies of Complement Proteins in Man....Pages 409-419
The Role of Complement in Experimental Disease Models....Pages 421-428
The Role of Complement in Immune Clearance of Blood Cells....Pages 429-454
Front Matter....Pages 407-407
Methods to Detect and Quantitate Complement Activation....Pages 455-472
Addendum to: Synthesis of Complement by Macrophages and Modulation of Their Functions Through Complement Activation (pp. 279–322)....Pages 473-474