Clinical Pharmacology & Therapeutics: Proceedings of Plenary Lectures Symposia and Therapeutic Sessions of the First World Conference on Clinical Pharmacology & Therapeutics London, UK, 3–9 August 1980

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
The Ethical and Scientific Basis of Regulation....Pages 3-8
Predictive Value of Pre-Clinical Drug Safety Evaluation....Pages 9-14
The Pharmacology and Clinical Potential of Prostacyclin....Pages 15-32
Possible Physiological Roles of the Enkephalins and Endorphins....Pages 33-48
Front Matter....Pages 49-49
Variability in Human Drug Metabolism....Pages 51-62
Gene-Environment Interactions in Drug Metabolism....Pages 63-79
Importance of Purification of Hepatic Cytochrome P-450 for Studying Drug Metabolism in Man....Pages 80-85
Front Matter....Pages 87-87
Biological Ageing....Pages 89-97
Drug Metabolism at Various Ages — Young....Pages 98-107
Methodological Problems Associated with Studies of Drug Metabolism in the Elderly....Pages 108-116
Renal Elimination of Drugs at Various Ages....Pages 117-123
Responsiveness to Drugs at Extremes of Age....Pages 124-131
Front Matter....Pages 133-133
The Effects of Digoxin on Red Cell Digitalis Receptor Function in Man....Pages 135-144
Mechanisms for Regulation of β-Adrenergic Receptor Function in Desensitization....Pages 145-153
Reversal of Pharmacological and Biochemical Effects of Neuroleptic Drugs on Chronic Administration....Pages 154-157
α-Adrenoceptors and the Clinical Pharmacology of Clonidine....Pages 158-164
The Effect of Oral Contraceptives on Platelet Noradrenaline and 5-Hydroxytryptamine Receptors and Aggregation....Pages 165-174
Assessment of β-Adrenoceptor down Regulation in Man....Pages 175-178
Front Matter....Pages 179-179
Inotropic Agents: An Overview....Pages 181-187
Inotropic Drugs in Clinical Practice....Pages 188-193
Front Matter....Pages 195-195
The Mechanisms of Action of Drugs that Modify Platelet and Vessel Wall Function....Pages 197-212
The Effectiveness of Drugs that Modify Platelet Function in Peripheral Venous Thrombosis and Pulmonary Embolism....Pages 213-223
Basic Current Evidence for the Use of Drugs to Both Prevent and Treat Patients with Venous Thrombosis and Pulmonary Embolism....Pages 224-233
The Value of Drugs that Modify Platelet and Vessel Wall Function for the Clinical Complications of Atherosclerosis....Pages 234-241
Front Matter....Pages 242-247
Individualization of Antihypertensive Treatment....Pages 249-249
Does the Assay of Catecholamine Levels Contribute to the Tailoring of Antihypertensive Treatment?....Pages 251-255
β-Adrenoceptor Blocking Drugs and the Renin-Angiotensin System....Pages 256-263
Rational Approaches to Clinical Therapy....Pages 264-269
Front Matter....Pages 270-274
The Therapeutic and Toxic Effects of Anti-Inflammatory Drugs Which Interfere with Arachidonic Acid Metabolism....Pages 275-275
Clinical Effects and Interactions of the Non-Steroidal Anti-Inflammatory Drugs....Pages 277-287
Specific Therapy for Rheumatoid Arthritis....Pages 288-297
Immunological Modification to Treat Rheumatoid Arthritis....Pages 298-303
Front Matter....Pages 304-309
Perspectives on Pain....Pages 311-311
Nociceptive Pathways and Transmitters....Pages 313-316
Analgesia Produced by Stimulation of the Nervous System....Pages 317-327
Endorphins and Central Neurotransmitters in Clinical Pain....Pages 328-337
Psychological Aspects of Pain....Pages 338-344
Front Matter....Pages 345-349
Clinical Pharmacological Actions and Potential Therapeutic Effects of Marihuana and Related Drugs....Pages 351-351
Alcohol: the Old Rascal in New Clothes....Pages 353-359
Front Matter....Pages 360-367
Clinical Pharmacology of Benzodiazepine Dependence....Pages 351-351
Relationships of γ-Endorphin in Physical Dependence....Pages 368-372
Methadone Maintenance Treatment of Heroin Addiction in Sweden....Pages 373-381
Front Matter....Pages 382-391
Principles of Percutaneous Absorption....Pages 393-393
Biochemical Pharmacology of the Epidermis....Pages 395-403
Drug Metabolism in Skin....Pages 404-409
UV Inflammation and Anti-Inflammatory Drugs....Pages 410-414
Objective Comparison of the Response of Psoriasis to Treatment with Puva and Dithranol....Pages 415-420
Front Matter....Pages 421-423
Recent Studies on Bleomycin....Pages 425-425
Regression Analysis of 4′-(9-Acridinylamino) Methanesulphon-m-Anisidide (m-AMSA) Analogue Properties Providing High Dose-Potency in Leukaemia L1210 Assays....Pages 427-435
Front Matter....Pages 436-442
Therapy of Tropical Diseases — Schistosomiasis....Pages 443-443
Therapy of Tropical Diseases — Filariasis....Pages 445-448
Front Matter....Pages 449-460
Dilemmas in Contraceptive Development: Variation in Endocrine Response to Low Dose Progestogens....Pages 461-461
Controversies in the Clinical Evaluation of Antifertility Plants....Pages 463-473
International Trials and Tribulations....Pages 474-482
The First Clinical Trial of Gossypol on Male Antifertility....Pages 483-488
Comparative Pharmacodynamics and Pharmacokinetics of Contraceptive Steroids in Animals and Man: A Selective Review....Pages 489-492
Front Matter....Pages 493-518
Problems of Drug Evaluation in Developing Countries....Pages 519-519
The World Health Organization Essential Drug Concept — Three Years Afterwards....Pages 521-528
Drugs for Developing Countries — The Views of a Practising Doctor in the Tropics....Pages 529-535
Front Matter....Pages 536-543
Drugs for Developing Countries: View of the Pharmaceutical Industry....Pages 519-519
Front Matter....Pages 544-547
Ethical and Legal Problems in Medicinal Therapeutics....Pages 549-549
Principles of No-Fault or Strict Liability....Pages 551-556
A No-Fault or Strict Liability Scheme in Action — Sweden....Pages 557-564
The Responsibility of the Pharmaceutical Industry....Pages 565-571
....Pages 572-576