دسترسی نامحدود
برای کاربرانی که ثبت نام کرده اند
دانلود کتاب Clinical Ophthalmic Oncology: Uveal Tumors
دانلود کتاب انکولوژی چشمی بالینی: تومورهای Uveal
مشخصات کتاب
Clinical Ophthalmic Oncology: Uveal Tumors
ویرایش: [3 ed.] نویسندگان: Bertil E. Damato, Arun D. Singh سری: ISBN (شابک) : 9783030178796, 303017879X ناشر: Springer سال نشر: 2019 تعداد صفحات: 459 زبان: English فرمت فایل : EPUB (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 293 Mb
قیمت کتاب (تومان) : 46,000
در صورت تبدیل فایل کتاب Clinical Ophthalmic Oncology: Uveal Tumors به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب انکولوژی چشمی بالینی: تومورهای Uveal نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب انکولوژی چشمی بالینی: تومورهای Uveal
ویرایش سوم این کتاب شش جلدی که توسط کارشناسان مشهور بین المللی نوشته شده است، راهنمایی و توصیه های عملی مفصلی را در مورد تشخیص و مدیریت طیف کاملی از سرطان های چشمی ارائه می دهد. این کتاب با ارائه دانش پیشرفته مورد نیاز برای شناسایی زودهنگام این سرطان ها و درمان هرچه مؤثرتر آنها، در شش جلد تقسیم شده است: اصول اساسی، تومورهای پلک و ملتحمه، تومورهای چشمی، تومورهای Uveal. تومورهای شبکیه و رتینوبلاستوما. اطلاعات ارائه شده به خوانندگان این امکان را می دهد تا با استفاده از آخرین دانش در مورد انکولوژی چشم، مراقبت موثری از بیمار ارائه دهند و نتایج تشخیصی را بر اساس مقایسه با عکس های بالینی تمام رنگی متعدد از مجموعه های خصوصی نویسندگان، میکروعکس های هیستوپاتولوژیک، مطالعات تصویربرداری، و تصاویر واضح تأیید کنند. قالب بالینی متمرکز و کاربرپسند Clinical Ophthalmic Oncology امکان بازیابی سریع اطلاعات را در عمل روزانه فراهم می کند و برای دستیاران، همراهان و هر پزشک درگیر در مراقبت از بیماران مبتلا به بدخیمی های چشمی یا اربیتال نوشته شده است. علاوه بر این، این نسخه صدها تصویر جدید را برای بهبود درک روش ها و تکنیک ها اضافه می کند. این جلد صرفاً به تومورهای یووئال اختصاص یافته است، روش‌های مختلف تشخیصی و بیوپسی را توضیح می‌دهد و گزینه‌های درمانی برای انواع مختلف تومورهای یووئال و شرایط شبیه‌سازی آنها را توضیح می‌دهد.
توضیحاتی درمورد کتاب به خارجی
Written by internationally renowned experts, the 3rd edition of this six volume textbook provides detailed practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into six volumes: Basic Principles, Eyelid and Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, and Retinoblastoma. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Clinical Ophthalmic Oncology's clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. Additionally, this edition adds several hundred new images to improve comprehension of procedures and techniques. This volume is devoted solely to uveal tumors, explaining various diagnostic and biopsy techniques, and describing the therapeutic options for different types of uveal tumors and their simulating conditions.
فهرست مطالب
Preface Acknowledgments Contents Contributors 1: Uveal Tumors: Examination Techniques Introduction History Taking Initial Assessment Follow-Up Visual Acuity Slit-Lamp Examination Indirect Ophthalmoscopy Fundus Drawing Estimation of Intraocular Tumor Basal Dimensions Three-Mirror Examination Transillumination Color Photography Ancillary Tests Conclusion References 2: Classification of Uveal Tumors Introduction Classification of Uveal Tumors Etiologic Classification Histopathologic Classification Histogenetic Classification Genotypic “Classification” TNM Staging Conclusions References 3: Benign Melanocytic Tumors of the Uvea Iris Nevus Introduction Etiology and Pathology Clinical Features Clinical Variants Tapioca Iris Nevus Diffuse Iris Nevus Iris Nevus Syndrome Iris Mammillations Lisch Nodules Aggressive Nevi of Childhood Diagnostic Evaluation Differential Diagnosis Treatment Prognosis Choroidal Nevus Introduction Terminology Etiology and Pathology Clinical Features Symptoms Signs Clinical Variants Amelanotic Nevus Halo Nevus Choroidal Melanocytosis Indeterminate Choroidal Melanocytic Lesions Large or Giant Nevus Slow Growth and Progressive Surface Changes Risk Factors for Malignant Transformation Diagnostic Evaluation Differential Diagnosis Treatment Ciliary Body Nevus Clinical Features Complications Treatment Melanocytosis Introduction Association with Uveal Melanoma Biological Basis Risk Estimate Clinical Variants Treatment Optic Disc Melanocytoma Introduction Etiology Pathology Clinical Features Symptoms Signs Associations Differential Diagnosis Diagnostic Evaluation Treatment Prognosis Uveal Melanocytoma Iris Melanocytoma Clinical Features Complications Treatment Ciliary Body Melanocytoma Clinical Features Complications Treatment Choroidal Melanocytoma Clinical Features Complications Treatment References 4: Uveal Melanoma: Epidemiologic Aspects Introduction Incidence Global Incidence Sex- and Age-Specific Incidence Uveal Melanoma in Pregnancy Temporal Stability Host Factors Skin Color/Race Iris Color Cutaneous Nevi Uveal Nevi Genetic Predisposition Familial Uveal Melanoma Uveal Melanoma in Young Individuals Congenital Uveal Melanoma Bilateral Uveal Melanoma Multifocal Uveal Melanoma Phenotypic Associations Oculo(Dermal) Melanocytosis Phakomatosis Pigmentovascularis FAM-M Syndrome Neurofibromatosis Type 1 Li-Fraumeni Syndrome Second Malignant Neoplasms BAP1 Cancer Predisposition Syndrome Germline BRCA1 /BRCA2 Mutation Environmental Factors Sunlight Exposure Occupation Summary References 5: Uveal Melanoma: Clinical Features Introduction Iris Melanoma Circumscribed Iris Melanoma Diffuse Iris Melanoma Ciliary Body Melanoma Circumscribed Ciliary Body Melanoma Annular (Ring) Ciliary Body Melanoma Choroidal Melanoma Symptoms Pigmentation Size and Shape Variants Retinal Detachment Intraocular Pressure Inflammation Extraocular Extension References 6: Uveal Melanoma: Differential Diagnosis Posterior Segment Tumors Choroidal Freckle Melanocytic Nevus Melanoma Metastasis Hemangioma Uveal Effusion Suprachoroidal Hemorrhage Choroidal Osteoma Sclero-choroidal Calcification Vortex Vein Ampulla Uveal Lymphoma Neurilemmoma Bilateral Diffuse Uveal Melanocytic Proliferation Peripheral Exudative Chorioretinopathy (“Eccentric Disciform”) Iris Tumors Nevus Melanoma Melanocytoma Metastasis Cysts Juvenile Xanthogranuloma Iris Freckle Conclusions References 7: Uveal Melanoma: Histopathologic Features Introduction Growth Patterns Dome Shape Collar-Stud Shape Diffuse Growth Pattern Ring Melanoma Retinoinvasive Melanoma Local Invasion Sclera Retina Optic Nerve Secondary Intraocular Effects Retinal Pigment Epitheliopathy Retinal Detachment Secondary Glaucoma Histopathologic Survival Predictors Primary Uveal Melanoma Cell Type Pigmentation Nucleolar Size Mitotic Figures Extravascular Matrix Patterns Cytological Diagnosis Immunohistochemical Prognostic Indicators Irradiated Uveal Melanoma Metastatic Uveal Melanoma References 8: Uveal Melanoma: Molecular Pathology Introduction Uveal Melanoma and the “Hallmarks of Cancer” Molecular Pathway Defects in Primary Uveal Melanoma Chromosomal Alterations in Primary Uveal Melanoma Molecular Alterations Influencing Uveal Melanoma Metastasis Molecular Alterations in Uveal Melanoma Metastases Strategies for Targeted Therapy in Uveal Melanoma Metastases References 9: Animal Models in Uveal Melanoma Introduction The Importance of Animal Models in UM Types of Animal Models in UM Spontaneous Models Syngeneic Models Xenotransplantation Models Transgenic Models Induced Models Applications of Human Uveal Melanoma Models Primary Ocular Disease Natural History of Uveal Melanoma Cancer Angiogenesis and Immunology Tumor Dormancy Metastasis Liquid Biopsy Treatment Strategies Conclusion and Future Directions References 10: Iris Melanoma Introduction Etiology and Pathogenesis Pathology Clinical Features Ciliary Body Melanoma Differential Diagnosis Iris and Ciliary Body Nevus Iris and Ciliary Body Melanocytoma Iris Pigment Epithelial (IPE) Cyst Iris Stromal Cyst Iridocorneal Epithelial (ICE) Syndrome Iris Metastases Nonmelanocytic Tumors Diagnostic Methods Management Observation Surgical Excision Enucleation Plaque Radiotherapy Proton Beam Metastases References 11: Management of Patients with Posterior Uveal Melanoma Introduction Detection Referral Procedure Diagnosis TNM Staging Ocular Treatment Objectives Ocular Treatment Selection Radiotherapy Episcleral Plaque Radiotherapy Proton Beam Radiotherapy Stereotactic Radiotherapy Phototherapy Photocoagulation Transpupillary Thermotherapy Photodynamic Therapy Cryotherapy Tumor Resection Trans-scleral Resection Endoresection Enucleation Ancillary Treatments Prognostication Screening for Systemic Disease Systemic Therapy Aftercare Counseling Organization of Patient Care Future Trends Non-mydriatic Fundus Cameras Intraocular Tumor Biopsy and Survival Prognostication Adjuvant Systemic Therapy Improved Visual Outcomes Increased Patient Expectations Clinical Trials Conclusions References 12: Uveal Melanoma: Brachytherapy Introduction Radiation Episcleral Radioactive Plaque Plaque Design Dosimetry Treatment Preoperative Assessment Plaque Positioning Follow-Up Radiation Safety Plaque Modifications Combined Treatment Collateral Damage to Ocular Tissues Intraoperative Complications Cataract Optic Neuropathy Retinopathy Neovascular Glaucoma Scleral Melting Choroidal Atrophy Results Visual Outcome Local Tumor Recurrence Ocular Conservation Quality of Life Survival Summary References 13: Uveal Melanoma: Proton Beam Radiation Therapy Introduction Proton Beam Radiotherapy Patient Evaluation Pre-radiation Surgery Proton Treatment Planning Irradiation Procedure Follow-Up Protocol Patient Characteristics Ophthalmic Outcomes Local Control Eye Loss Vision Loss Complications Metastasis and Survival Summary References 14: Uveal Melanoma: Stereotactic Radiation Therapy Introduction Types of Stereotactic Radiotherapy Stereotactic Radiosurgery Fractionated Stereotactic Radiotherapy Stereotactic Radiosurgery Treatment Planning Procedure Gamma Knife Results Tumor Control and Complications Metastasis Fractionated Stereotactic Radiotherapy Treatment Planning Procedure Linear Accelerator Results Tumor Control and Complications Metastasis Indications and Contraindications Conclusions References 15: Uveal Melanoma: Phototherapy Introduction Photocoagulation Indications Methods Results Transpupillary Thermotherapy Indications Methods Results Photodynamic Therapy Indications Methods Results AURA Conclusions References 16: Uveal Melanoma: Resection Techniques Introduction Iridectomy Indications and Contraindications Surgical Technique Results and Complications Iridocyclectomy Indications and Contraindications Surgical Technique (Fig. 16.2) Results and Complications Trans-scleral Choroidectomy Indications and Contraindications Surgical Technique (Fig. 16.4) Results and Complications Incomplete Tumor Resection Rhegmatogenous Retinal Detachment Expulsive Hemorrhage Choroidal Tears Systemic Complications of Hypotensive Anesthesia Metastasis Transretinal Choroidectomy Indications and Contraindications Surgical Technique (Fig. 16.6) Results and Complications Tumor Recurrence Rhegmatogenous Retinal Detachment Other Complications Conclusions References 17: Uveal Melanoma: The Collaborative Ocular Melanoma Study Introduction Eligibility and Exclusion Criteria COMS Classification of Choroidal Melanoma Main Outcome Measures COMS Trials and Observational Studies Small Choroidal Melanoma Observational Study Growth of Small Choroidal Melanoma Mortality with Small Choroidal Melanoma Medium Choroidal Melanoma: Randomized Trial of Enucleation vs. Brachytherapy Visual Outcome Following Brachytherapy Local Treatment Failure and Secondary Enucleation Mortality with Medium Choroidal Melanoma Large Choroidal Melanoma: Randomized Trial of Enucleation Alone vs. Pre-enucleation Irradiation Local Complications of Enucleation Mortality with Large Choroidal Melanoma Natural History Observational Study: Medium and Large Choroidal Melanoma Adjunct Studies Quality of Life Cross-Sectional Study of Medium Choroidal Melanoma Histopathologic Features of Choroidal Melanoma Screening and Development of Metastatic Disease Second Primary Cancers Trends in the Size and Treatment of Choroidal Melanoma Incidence of Cataracts After Iodine-125 Brachytherapy Summary References 18: Uveal Melanoma: Prognostic Factors Introduction The Primary Tumor: Characteristics Detectable by Clinical Criteria The Primary Tumor: Pathological Features Derived from the Examination of Tumor Tissue Cytogenetic and Molecular Testing References 19: Uveal Melanoma: Prognostication Methods Introduction Molecular Techniques Prognostication Modeling Conclusions References 20: Uveal Melanoma: Mortality Introduction Uveal Melanoma Mortality Misinterpretation of Survival Data Erroneous Death Certification Competing Risks Lead-Time Bias Loss to Follow-Up Influence of Ocular Therapy on Mortality Onset of Metastatic Spread Enucleation Radiotherapy Local Resection Trans-pupillary Thermotherapy Delayed Treatment Systemic Treatment Iris Melanoma Conclusions References 21: Uveal Melanoma: Adjuvant Therapy Introduction Considerations in the Development of Adjuvant Therapies Adjuvant Systemic Therapeutic Strategies Chemotherapy Dacarbazine and Temozolomide Fotemustine (Systemic Versus Intra-arterial Hepatic Infusion) Future Directions Targeted Therapy Sunitinib Crizotinib Future Directions Immunotherapy IFN Dendritic Cell Vaccination Checkpoint Inhibition Future Directions Epigenetic Approaches HDAC Inhibition Future Directions Novel Approaches Neddylation Blockade and Targeting Dormancy Adjuvant Regional Therapeutic Strategies Conclusion References 22: Uveal Melanoma: Metastases Introduction Pathogenesis Clinical Features Frequency of Metastasis Sites of Metastasis Determinants of Metastasis Signs and Symptoms Diagnostic Evaluation Treatment Options Systemic Chemotherapy Immunotherapy Targeted Therapy Locoregional Surgical Resection Chemoembolization Immunoembolization Intra-arterial Hepatic Chemotherapy Radioembolization Adoptive Transfer of Tumor-Infiltrating Lymphocytes Adjuvant Therapy Prognosis Future Research References 23: Uveal Vascular Tumors Introduction Iris Hemangioma Introduction Clinical Features Diagnostic Evaluation Differential Diagnosis Treatment Prognosis Ciliary Body Hemangioma Circumscribed Choroidal Hemangioma Introduction Clinical Features Symptoms Signs Differential Diagnosis Diagnostic Evaluation Treatment Observation Laser Photocoagulation Thermotherapy Radiotherapy Photodynamic Therapy Other Methods Prognosis Diffuse Choroidal Hemangioma Introduction Clinical Features Symptoms Signs Diagnostic Evaluation Differential Diagnosis Treatment Observation Radiotherapy Photodynamic Therapy Other Methods Prognosis References 24: Uveal Neural Tumors Introduction Uveal Neurofibroma Pathology Diagnosis Treatment Uveal Schwannoma Pathology Diagnosis Treatment References 25: Intraocular Manifestations of Hematopoietic Disorders Introduction Leukemias Acute Myeloid Leukemia (AML) Acute Lymphoblastic Leukemia (ALL) Chronic Myeloid Leukemia (CML) Chronic Lymphocytic Leukemia (CLL) Myelodysplastic Syndromes (MDS) Ophthalmic Manifestations Retina Choroid Optic Nerve Vitreous Iris and Anterior Chamber Polycythemia Vera (Vaquez Disease) Essential Thrombocythemia Graft-Versus-Host Disease Management of Ocular Leukemia Prognosis Drug Toxicity References 26: Uveal Myogenic, Fibro-histiocytic, and Histiocytic Tumors Introduction Etiology Pathogenesis Clinical Features Symptoms Signs Diagnostic Evaluation Salient Diagnostic Findings Macroscopic Pathology Microscopic Pathology Immunohistochemical Findings Ultrastructural Findings Cytogenetic Analysis Differential Diagnosis Treatment Follow-Up Prognosis Rhabdomyosarcoma Fibro-histiocytic Tumors Diagnostic Evaluation Macroscopic Pathology Histology, Immunohistochemistry, and Ultrastructure Treatment Histiocytic Tumors Juvenile Xanthogranuloma Etiology/Pathogenesis Clinical Features Histology, Immunohistochemistry, and Ultrastructure Treatment and Prognosis Langerhans Cell Histiocytosis Etiology/Pathogenesis Clinical Features Histology, Immunohistochemistry, and Ultrastructure Treatment Summary References 27: Uveal Lymphoproliferative Tumors Introduction Primary Choroidal Lymphoma Etiology and Pathogenesis Clinical Features Symptoms Signs Diagnostic Evaluation Histology Morphology Immunohistochemistry Clonality Analysis and FISH Testing Differential Diagnosis Treatment Prognosis Primary Iridal Lymphoma Etiology and Pathogenesis Clinical Features Symptoms Signs Diagnostic Evaluation Cytology and Histology Differential Diagnosis Treatment Prognosis Primary Ciliary Body Lymphoma References 28: Uveal Metastatic Tumors Introduction Incidence and Prevalence Clinical Features Symptoms Signs Choroidal Metastasis Iris and Ciliary Body Metastasis Diagnostic Evaluation Systemic Workup Fluorescein and Indocyanine Angiography Ultrasonography Optical Coherence Tomography Magnetic Resonance Imaging Biopsy Differential Diagnosis Treatment Chemotherapy Hormonal Therapy Targeted Therapy Radiotherapy Phototherapy Anti-VEGF Therapy Surgical Treatment Prognosis References 29: Uveal Osseous Tumors Introduction Choroidal Osteoma Etiology Pathology Clinical Features Symptoms Signs Course Complications Diagnostic Evaluation (Box 29.1) Ultrasonography B-Scan Fluorescein Angiography Indocyanine Angiography Optical Coherence Tomography Autofluorescence Computed Tomography Salient Diagnostic Findings Differential Diagnosis Treatment Observation Intravitreal Anti-VEGF Photodynamic Therapy Laser Photocoagulation Prognosis Sclerochoroidal Calcification Etiology Pathology Clinical Features Symptoms Signs Diagnostic Evaluation (Box 29.2) Box 29.2 Features of Sclerochoroidal Calcification Ultrasonography Fluorescein Angiography Optical Coherence Tomography Computed Tomography Metabolic Evaluation Differential Diagnosis Treatment Prognosis References 30: Bilateral Diffuse Uveal Melanocytic Proliferation Introduction Clinical Features Differential Diagnosis Treatment References Index
