Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Clinical relevance....Pages 3-12
Renal handling of drugs and xenobiotics....Pages 13-30
Immunologically-mediated toxin-induced renal diseases....Pages 31-38
Cellular mechanisms of nephrotoxicity....Pages 39-59
Experimental models....Pages 61-99
Front Matter....Pages 101-101
Introduction Anti-infectious agents....Pages 103-104
Aminoglycosides and vancomycin....Pages 105-120
The renal toxicity of beta-lactam antibiotics: Mechanisms and clinical implications....Pages 121-134
Amphotericin B....Pages 135-151
Miscellaneous drugs with nephrotoxic potential (Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones)....Pages 153-173
Antiviral agents....Pages 175-186
Introduction Analgesic related renal injury....Pages 187-187
Analgesics....Pages 189-201
Nonsteroidal anti-inflammatory drugs: Effects on kidney function....Pages 203-216
5-Aminosalicylic acid and chronic interstitial nephritis....Pages 217-222
Nephrotoxicity of gold salts, D-penicillamine, and allopurinol....Pages 223-238
Renal injury from angiotensin I converting enzyme inhibitors....Pages 239-250
Diuretics....Pages 251-260
Anticancer: Cisplatin/carboplatin....Pages 261-271
Introduction Immunosuppressive drugs....Pages 273-274
Front Matter....Pages 101-101
Cyclosporine/tacrolimus (FK-506)....Pages 275-300
OKT3 Nephrotoxicity: From acute tubular necrosis to hemolytic uremic syndrome....Pages 301-309
Cytokine associated renal dysfunction: Interleukins and interferons....Pages 311-316
Contrast associated nephropathy: Presentation, pathophysiology and management....Pages 317-331
Introduction Environmental nephrotoxins....Pages 333-333
Lead nephropathy....Pages 335-343
Cadmium-induced renal effects in the general environment....Pages 345-361
Mercury....Pages 363-370
Role of environmental/occupational exposure to organic, silicon-containing compounds and pesticides in the development and progression of renal disease....Pages 371-382
Lithium and the kidney....Pages 383-395
Renal disease associated with illicit drug abuse....Pages 397-411
Renal toxicity of anesthetic agents....Pages 413-418
Nephrotoxicity of herbal remedies and trace elements used as food additives....Pages 419-423
Balkan nephropathy....Pages 425-436
Front Matter....Pages 437-437
Urinary biomarkers and nephrotoxicity....Pages 439-463
Principles of drug dosing in renal failure....Pages 465-468
Practical dosing....Pages 469-478
Back Matter....Pages 479-481