Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals

Clinical relevance....Pages 3-20
Renal handling of drugs and xenobiotics....Pages 21-46
Pharmacovigilance....Pages 47-50
Immunologically-mediated toxin-induced renal disease....Pages 51-64
Cellular mechanisms of nephrotoxicity....Pages 65-76
Animal models for the assessment of acute renal dysfunction and injury....Pages 77-114
Renal cell culture models: Contribution to the understanding of nephrotoxic mechanisms....Pages 115-147
Aminoglycosides and vancomycin....Pages 151-170
Beta-lactam antibiotics....Pages 171-198
Amphotericin B....Pages 199-222
Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones....Pages 223-247
Antiviral agents....Pages 249-262
Analgesics and 5-aminosalicylic acid....Pages 263-278
Non-steroidal anti-inflammatory drugs....Pages 279-306
Gold salts, D-penicillamine and allopurinol....Pages 307-324
Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists....Pages 325-338
Diuretics....Pages 339-351
Anticancer drugs....Pages 353-372
Anesthetic agents....Pages 373-381
Illicit drug abuse....Pages 383-402
Calcineurin inhibitors and sirolimus....Pages 403-458
Immunomodulators: interleukins, interferons, and the OKT3 monoclonal antibody....Pages 459-482
Radiocontrast agents....Pages 483-494
Lead nephropathy....Pages 495-506
Cadmium-induced renal effects....Pages 507-530
Mercury-induced renal effects....Pages 531-544
Hydrocarbons, silicon-containing compounds and pesticides....Pages 545-558
Lithium-induced renal effects....Pages 559-578
Aristolochic acid nephropathy after Chinese herbal remedies....Pages 579-586
Balkan endemic nephropathy....Pages 587-601
Nephrotoxins in Africa....Pages 603-610
Paraphenylene diamine hair dye poisoning....Pages 611-618
Urinary biomarkers and nephrotoxicity....Pages 621-655
Pharmacological aspects of nephrotoxicity....Pages 657-666
Drug dosage in renal failure....Pages 667-679