Clinical Aspects of Interferons

Front Matter....Pages i-xxvii
Front Matter....Pages 1-1
Intranasal Interferons for Control of Respiratory Viral Infections....Pages 3-16
Interferon Therapy of Herpes Simplex Dermal Infections and Papillomavirus Condylomata....Pages 17-38
Interferon Therapy in Acute Viral Illnesses....Pages 39-61
Kaposi’s Sarcoma and AIDS: The Role of Interferons in Treatment....Pages 62-74
Use of Interferon in the Treatment of Subacute Sclerosing Panencephalities....Pages 75-83
Multiple Sclerosis: Clinical Trials with Interferons....Pages 85-94
The Promise of Interferon Therapy for Parasitic Diseases....Pages 95-105
Front Matter....Pages 107-108
Interferon Treatment of Non-Hodgkin’s Lymphoma and Myeloma: A Model for Biotherapy....Pages 109-120
The Role of Interferon Alpha in the Treatment of Hairy Cell Leukemia (HCL)....Pages 121-126
Clinical Studies of Alpha and Gamma Interferons in Chronic Myelogenous Leukemia....Pages 127-139
Interferon Therapy of Chronic Lymphocytic Leukemia and Viral Infections in Leukemia Patients....Pages 141-148
Interferons in the Treatment of Metastatic Renal Cell Carcinoma (RCC)....Pages 149-156
Interferons in Breast Cancer....Pages 157-164
Osteosarcoma Management and Interferon....Pages 165-181
Clinical Use of Interferons in the Treatment of Malignant Brain Tumors....Pages 183-194
Interferon Treatment of Neuro-Endocrine Tumors of Pancreas and Gut....Pages 195-212
The Role of Beta Interferon in the Treatment of Cervical Dysplasia....Pages 213-226
Interferons in Combination with Cytotoxic Modalities for Cancer Treatment....Pages 227-241
Front Matter....Pages 243-243
Toxic Effects....Pages 245-258
Pharmacokinetics of Interferons and Practical Implications....Pages 259-269
Front Matter....Pages 243-243
Monitoring of Interferon Therapy by Assay of Interferon-Induced (2′–5′) Oligo a Synthetase in Human Peripheral White Blood Cells....Pages 271-283
Interferon Studies in Non-Human Primates....Pages 285-306
Animal Model Systems to Evaluate the Antitumor Activity of Interferons....Pages 307-317
Effects of Polynucleotides on Monkeys and Man....Pages 319-331
Delivery of Interferons to Target Cells by Monoclonal Antibodies: Potential for the Specific Targeting of Other Lymphokines....Pages 333-339
Immunomodulatory Actions of Interferons....Pages 341-351
Synergistic Actions of Interferons and Tumor Necrosis Factor....Pages 353-363
Back Matter....Pages 365-366