Chronic Inflammation: Mechanisms and Regulation

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Prostaglandins in Chronic Inflammation....Pages 3-17
Cellular and Molecular Mechanisms of Chronic Inflammation-Associated Organ Fibrosis....Pages 19-36
Sema4A and Chronic Inflammation....Pages 37-48
MicroRNAs in Chronic Inflammation....Pages 49-61
Genetic Dissection of Autoinflammatory Syndrome....Pages 63-75
Structural Biology of Chronic Inflammation-Associated Signalling Pathways: Toward Structure-Guided Drug Development....Pages 77-88
Lipid Signals in the Resolution of Inflammation....Pages 89-96
Regulation of Chronic Inflammation by Control of Macrophage Activation and Polarization....Pages 97-107
Clarification of the Molecular Mechanisms That Negatively Regulate Inflammatory Responses....Pages 109-118
The Drosophila Toll Pathway: A Model of Innate Immune Signalling Activated by Endogenous Ligands....Pages 119-129
Front Matter....Pages 131-131
Macrophage Dynamics During Bone Resorption and Chronic Inflammation....Pages 133-145
Visualization of Localized Cellular Signalling Mediators in Tissues by Imaging Mass Spectrometry....Pages 147-160
Tracking of Follicular T Cell Dynamics During Immune Responses and Inflammation....Pages 161-169
Front Matter....Pages 171-171
The Role of Chronic Inflammation in the Promotion of Gastric Tumourigenesis....Pages 173-186
Cellular Senescence as a Novel Mechanism of Chronic Inflammation and Cancer Progression....Pages 187-200
Establishment of Diagnosis for Early Metastasis....Pages 201-210
Non-autonomous Tumor Progression by Oncogenic Inflammation....Pages 211-222
Inflammation-Associated Carcinogenesis Mediated by the Impairment of microRNA Function in the Gastroenterological Organs....Pages 223-233
Roles of Epstein–Barr Virus Micro RNAs in Epstein–Barr Virus-Associated Malignancies....Pages 235-245
Front Matter....Pages 247-247
Chronicity of Immune Abnormality in Atopic Dermatitis: Interacting Surface Between Environment and Immune System....Pages 249-275
Front Matter....Pages 247-247
Role of Double-Stranded RNA Pathways in Immunometabolism in Obesity....Pages 277-290
Molecular Mechanisms Underlying Obesity-Induced Chronic Inflammation....Pages 291-298
Roles of Mitochondrial Sensing and Stress Response in the Regulation of Inflammation....Pages 299-308
Oxidative Stress Regulation by Reactive Cysteine Persulfides in Inflammation....Pages 309-316
Front Matter....Pages 317-317
Posttranscriptional Regulation of Cytokine mRNA Controls the Initiation and Resolution of Inflammation....Pages 319-332
Roles of C-Type Lectin Receptors in Inflammatory Responses....Pages 333-344
Elucidation and Control of the Mechanisms Underlying Chronic Inflammation Mediated by Invariant Natural Killer T Cells....Pages 345-356
Understanding of the Role of Plasmacytoid Dendritic Cells in the Control of Inflammation and T-Cell Immunity....Pages 357-368
Mechanisms of Lysosomal Exocytosis by Immune Cells....Pages 369-378
Potential Therapeutic Natural Products for the Treatment of Obesity-Associated Chronic Inflammation by Targeting TLRs and Inflammasomes....Pages 379-397
Front Matter....Pages 399-399
Human and Mouse Memory-Type Pathogenic Th2 (Tpath2) Cells in Airway Inflammation....Pages 401-415
Controlling the Mechanism Underlying Chronic Inflammation Through the Epigenetic Modulation of CD4 T Cell Senescence....Pages 417-427
Adrenergic Control of Lymphocyte Dynamics and Inflammation....Pages 429-439
The Multifaceted Role of PD-1 in Health and Disease....Pages 441-457
The Role of Lysophospholipids in Immune Cell Trafficking and Inflammation....Pages 459-471
Front Matter....Pages 473-473
Devising Novel Methods to Control Chronic Inflammation Via Regulatory T Cells....Pages 475-488
Control of Chronic Inflammation Through Elucidation of Organ-Specific Autoimmune Disease Mechanisms....Pages 489-500
Lysophosphatidylserine as an Inflammatory Mediator....Pages 501-509
Aberrant Activation of RIG-I–Like Receptors and Autoimmune Diseases....Pages 511-523
Elucidation of the Exacerbation Mechanism of Autoimmune Diseases Caused by Disruption of the Ion Homeostasis....Pages 525-538
Front Matter....Pages 539-539
Pathophysiological Role of Chronic Inflammation in Ageing-Associated Diseases....Pages 541-553
Uterine Cellular Senescence in the Mouse Model of Preterm Birth....Pages 555-564
Front Matter....Pages 565-565
Physiological and Pathological Inflammation at the Mucosal Frontline....Pages 567-590
Control of Intestinal Regulatory T Cells by Human Commensal Bacteria....Pages 591-601
Roles of the Epithelial Autophagy in the Intestinal Mucosal Barrier....Pages 603-616
Development of Sentinel-Cell Targeted Therapy for Inflammatory Bowel Diseases....Pages 617-626
Identification of Long Non-Coding RNAs Involved in Chronic Inflammation in Helicobacter Pylori Infection and Associated Gastric Carcinogenesis....Pages 627-638
Front Matter....Pages 639-639
The Research for the Mechanism of Chronically Intractable Pain Based on the Functions of Microglia as Brain Immunocompetent Cell....Pages 641-648
The Role of Innate Immunity in Ischemic Stroke....Pages 649-660
Chronic Neuroinflammation Underlying Pathogenesis of Alzheimer’s Disease....Pages 661-671
Front Matter....Pages 673-673
The Roles of Hypoxic Responses During the Pathogenesis of Cardiovascular Diseases....Pages 675-683
Prevention and Treatment of Heart Failure Based on the Control of Inflammation....Pages 685-695
Back Matter....Pages 697-702