Chromosome Damage and Repair

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Damage to DNA Caused by Hydrolysis....Pages 3-18
Methylation of Cellular DNA by the Carcinogen N -Methyl- N -Nitrosourea and Removal of Methylpurines — Comparisons of Escherichia coli , Mouse and Human Cells....Pages 19-24
On the Use of a Damage-Specific DNA Binding Protein to Probe Lesions in DNA....Pages 25-29
DNA Chemically Modified by N-Acetoxy-N-2-Acetyl-Aminofluorene : Nature of the Adducts and Conformation of the Modified DNA....Pages 31-34
Heteroduplex DNA in Bacteriophage T1 after Ionizing Radiation....Pages 35-39
Influence of Alkylating Agents on the Structure of the Bacterial Nucleoid....Pages 41-47
Nucleosomal Structure of Chromatin : Distribution and Excision of DNA Damage....Pages 49-61
Electron-Microscopic Visualization of the AAF Binding Sites to DNA in Core Particles and Trinucleosomes by Means of Specific Antibodies....Pages 63-68
Studies of Molecular Events in Isolated Nucleolar Chromatin in Response to Chemicals and Ionizing Radiation....Pages 69-73
Front Matter....Pages 75-75
Base Excision Repair of DNA....Pages 77-84
Incision of Pyrimidine Dimer Containing DNA by Small Molecular Weight Enzymes....Pages 85-90
The Use of Direct Photoreversal of UV-Irradiated DNA for the Demonstration of Pyrimidine Dimer-DNA Glycosylase Activity....Pages 91-95
Enzymatic Studies of Base Excision Repair in Cultured Human Fibroblasts and in Escherichia coli ....Pages 97-112
Mechanism of Action of M. luteus Apurinic/Apyrimidinic Endonucleases....Pages 113-116
Properties of Uracil-DNA Glycosylases from M. luteus, E. coli and Mammalian Cells....Pages 117-121
Base Replacement Mechanisms for the Repair of Unnatural and Damaged Bases in DNA....Pages 123-129
Excision Repair of Bulky Lesions in the DNA of Mammalian Cells....Pages 131-138
Inducible Excision Repair in Escherichia coli ....Pages 139-146
On the Nature of the Repair Deficiency in E.coli uvrE ....Pages 147-151
Repair of UV-Damaged DNA Transformed into E. coli ....Pages 153-158
Front Matter....Pages 75-75
An Endonucleolytic Activity from M. luteus Directed Towards 8-(2-Hydroxy 2-Propyl)-Purines in DNA....Pages 159-165
Front Matter....Pages 167-167
Regulatory and Enzymatic Functions of recA Protein in Recombination and Postreplication Repair....Pages 169-180
 Haemophilus influenzae Does Not Fit Theories of Postreplication Repair....Pages 181-185
 RecA -Mediated Asymmetric Repair of Lethal DNA Lesions in E . coli ....Pages 187-191
 125 I Decay in Microorganisms: A Prokaryotic Model System for Examining the Role of Unrepaired Double-Strand DNA Breaks in Cell Killing....Pages 193-197
Protein “X” Synthesis in Mammalian Cells....Pages 199-204
Front Matter....Pages 205-205
DNA Methyl Transferase Acting on O 6 -Methylguanine Residues in Adapted E. coli ....Pages 207-217
Isolation of Mutants of Escherichia coli with Increased Resistance to Alkylating Agents....Pages 219-223
Effect of Rifampicin on N-Methyl-N-Nitrosourea-Induced Mutation Frequency in Escherichia coli ....Pages 225-231
The Enhanced Repair of O 6 -Alkylguanine in Mammalian Systems....Pages 233-245
Front Matter....Pages 247-247
The Use of DNA Tumour Viruses as Model Systems for Studying Damage and Repair of Eukaryotic Chromosomes: Analysis of Mutations by DNA Sequencing....Pages 249-260
Oligodeoxyribonucleotides as Site-Specific Mutagens....Pages 261-280
Cloning of recA + and lexA + and Some of Their Mutant Alleles; An Investigation of Their Mutual Interaction....Pages 281-285
Perturbation of the SOS Response of Escherichia coli by Plasmids Carrying Truncated recA Genes....Pages 287-291
Plasmids Carrying the uvrA and uvrC Genes of Escherichia coli K12: Construction and Properties....Pages 293-302
Cloning of the uvrC + Gene from Escherichia coli Onto a Plaque Forming Phage Vector....Pages 303-309
Front Matter....Pages 311-311
Xeroderma Pigmentosum — A Human Model of Defective DNA Repair....Pages 313-320
Correlation of Post-UV Colony-Forming Abilities of Xeroderma Pigmentosum Fibroblasts with DNA Incision Reactions Catalyzed by Cell-Free Extracts....Pages 321-328
Effects of Ultraviolet-Irradiation on DNA Ligase Activity of Human Fibroblasts from Normal and Xeroderma Pigmentosum Donors....Pages 329-333
Heritable Radiosensitive and DNA Repair-Deficient Disorders in Man....Pages 335-354
Front Matter....Pages 311-311
Studies on the Repair Defects of Ataxia Telangiectasia Cells....Pages 355-359
Ataxia-Telangiectasia: Studies on DNA Repair Synthesis in Fibroblast Strains....Pages 361-366
The Response of Cockayne Syndrome Cells to UV-Irradiation....Pages 367-371
Chromosomal Radiosensitivity in Fanconi’s Anaemia....Pages 373-379
Front Matter....Pages 381-381
DNA Replication in Mammalian Cells Damaged by Mutagens....Pages 383-388
Replication Processes in Chinese Hamster Cells Treated with Mutagenic Agents: Effects of Split Dose Treatments....Pages 389-393
Role of Mammalian DNA Polymerases in Replication and Repair....Pages 395-406
Evidence for a Role of DNA Helicase II in DNA Replication....Pages 407-413
DNA Replication in Cells with Polytene Chromosomes....Pages 415-418
Front Matter....Pages 419-419
Accuracy and Ageing....Pages 421-429
High Fidelity Devices in the Reproduction of DNA....Pages 431-445
Inhibition or Absence of DNA Proofreading Exonuclease is Not Sufficient to Allow Copying of Pyrimidine Dimers....Pages 447-459
On the Possible Role of the Miscoding DNA-Lesions, 1, N 6 -Etheno-Adenine and 3, N 4 -Ethenocytosine, in Vinyl Chloride-Induced Mutagenesis and Carcinogenesis....Pages 461-467
The Function of Methylated Bases in DNA of Escherichia coli ....Pages 469-473
Front Matter....Pages 475-475
(ADP-Ribose) n , A New Component in DNA Repair....Pages 477-487
Addition of UV Endonuclease to Permeable XP Cells to Analyze the Relation of Poly(ADPR) Synthesis to DNA Repair....Pages 489-495
Alkylation of Ehrlich Ascites Tumor Cells Elicits a Response from Poly(ADP-Ribose) Polymerase....Pages 497-501
Front Matter....Pages 503-503
Programmed Death of Escherichia coli after UV Radiation....Pages 505-510
Excision Repair Affects the Specificity of UV Mutagenesis in the lacI + Gene of Escherichia coli : Possible Involvement of Secondary DNA Structure....Pages 511-516
Hydrazine and Methylhydrazine as recA + Independent Mutagens in Escherichia coli ....Pages 517-520
Front Matter....Pages 503-503
Effects of Platinum Coordination Complexes on Mutants of Escherichia coli Defective in DNA Repair and Genetic Recombination....Pages 521-526
DNA Replication, Repair, and Mutagenesis in Permeable E . coli Cells That are Fully Viable....Pages 527-530
Involvement of ATP in Repair and Mutagenesis of X-Irradiated Mammalian Cells....Pages 531-534
Cell Cycle Patterns of Mutation Induction and Their Relationship to DNA Repair....Pages 535-538
Yeast as a Model for Studying DNA-Alterations and Biological Response Induced by Alkylating Anti-Cancer Drugs: Effects of Cyclophosphamide....Pages 539-547
Front Matter....Pages 549-549
Is Sister Chromatid Exchange Formation an Inducible Process?....Pages 551-556
Induction of Sister Chromatid Exchanges by Non-Mutagenic Carcinogens....Pages 557-562
Chromosome Aberrations and Sister Chromatid Exchanges in Persons Occupationally Exposed to Mutagens/Carcinogens....Pages 563-566
Sister-Chromated Exchanges as a Measure of Damage Produced by Visible Light on BrdUrd-Substituted Chromosomes....Pages 567-571
Front Matter....Pages 573-573
DNA Damage and Carcinogenesis....Pages 575-584
Some Parameters Affecting DNA Damage and Their Relevance to the Action of Chemical Carcinogens....Pages 585-595
Effect of a Tumor Promoter on DNA Repair After Treatment of C3H/10T½ Cells with a Carcinogen....Pages 597-604
Enhanced Survival of Ultraviolet-Damaged Parvovirus LuIII and Herpes Virus in Carcinogen Pretreated Transformed Human Cells....Pages 605-609
Back Matter....Pages 611-623