Chromosomal Alterations: Origin and Significance

Front Matter....Pages I-XI
Radiation-Induced Formation of DNA Double-Strand Breaks in Plasmids and E. coli ....Pages 1-9
UV-Induced Pyrimidine Monoadducts and their in vivo Photofootprints....Pages 10-20
Chromatin Structure, Hyperthermia and Repair of UV-Induced DNA Photolesions in Mammalian Cells....Pages 21-30
An Inherited Homogeneously Staining Region Derived from a Long-Range Repeat Family in the House Mouse....Pages 31-41
Detection of Genetic Imbalances in Tumor Genomes by Fluorescence in situ Hybridization with Tumor Genomic DNA and Subregional DNA Probes....Pages 42-49
Fluorescent in situ Hybridization (FISH) in Cytogenetical Studies....Pages 50-56
The Use of Premature Chromosome Condensation and Chromosome Painting to Understand Chromosome Exchange Formation....Pages 57-63
The Role of DNA Double-Strand-Break Rejoining in Chromosome Damage and Repair....Pages 64-75
Investigations of Aberration Origins Using BrdUrd....Pages 76-91
Elucidation of Some Factors Involved in the Formation of Chromosomal Aberrations by Inhibiting the Repair Polymerase....Pages 92-102
Use of Antitopoisomerase Drugs to Study the Mechanisms of Induction of Chromosomal Damage....Pages 103-115
Search for Perturbations induced by X-irradiation in the G2 Phase of Human Lymphocytes....Pages 116-124
A Comparison of Radiation-Induced Aberrations in Human Cells Involving Early and Late Replicating X-Chromosomes....Pages 125-131
Radioprotective Chemicals as Tools for Studying Mechanisms of Radiation-Induced Chromosome Damage in Human Lymphocytes....Pages 132-139
Factors Determining the Yields of Radiation-Induced Chromosomal Aberrations as Visualized by Means of Premature Chromosome Condensation in Interphase Cells....Pages 140-149
Synergism and Adaptive Response in the Interaction of Low Dose Irradiation with Subsequent Mutagenic Treatment in G2 Phase Human Lymphocytes....Pages 150-159
Responses of Radiosensitive Mutant Mammalian Cell Lines to Restriction Endonuclease induced DNA Double-Strand Breaks....Pages 160-168
Quantitative Localization of Chromatid Breaks Induced by Alu I in the Long Arms of Chromosomes Number 1 of Chinese Hamster Ovary (CHO) Cells by Microphotometric Scanning....Pages 169-183
“Life time” of AluI inside Glycerol-Induced Vesicles in CHO Cells....Pages 184-191
Progress in Automatic Dicentric Hunting....Pages 192-202
The Micronucleus Assay with Rodent Peripheral Blood and Acridine Orange Supravital Staining....Pages 203-213
The Formation of Micronuclei after Exposure to Ionizing Radiation....Pages 214-222
Excision Repaired Sites, Chromosome Breaks and Chromosome Loss Measured Simultaneously in Human Lymphocytes using the Cytokinesis Block Micronucleus Assay and Cytosine Arabinoside....Pages 223-234
The Potential of FISH for Meiotic Segregation Analysis....Pages 235-251
Reliable Chromosome Studies of Human Oocytes and Spermatozoa using the Gradual Fixation-Air Drying (GF-AD) Method....Pages 252-261
Nondisjunction by Failures in the Molecular Control of Oocyte Maturation....Pages 262-268
Cytogenetic and Molecular Investigations in Chromosomal Instability Syndromes....Pages 269-281
Distributions of Spontaneous Chromosomal Aberrations and of Spontaneous and Induced SCE and Micronuclei in Peripheral Lymphocytes from a Human Population....Pages 282-292
Does the Genetic Deficiency in ALDH2 Determine the Alcohol-Drinking Behavior and the Induction of Chromosome Alterations in Peripheral Lymphocytes by Alcohol?....Pages 293-306
Variability of Chromosomal Alterations in Human Peripheral Lymphocytes of Smokers and Nonsmokers....Pages 307-318
Chromosome Analysis in Accidental, Occupational and Environmental Radiation Exposure....Pages 319-332
New Approaches to Design and Interpretation of in vitro Chromosomal Aberration Tests....Pages 333-342
Comments on Short-Term Cytogenetic Assays for Screening of Environmental Chemical Carcinogens....Pages 343-347
Localized Chromosomal Aberrations in the Heterochromatic q Arm of the X Chromosome in V79 Chinese Hamster Cells and the Implications for Industrial in vitro Cytogenetic Screening....Pages 348-361
Cytogenetic Studies in Laboratory Animals Exposed by Inhalation to Mainstream Smoke or Environmental Tobacco Smoke....Pages 362-379
Evolutionary Aspects of Structural Chromosome Aberrations....Pages 380-394
Back Matter....Pages 395-402