Cholinesterases and Anticholinesterase Agents

Front Matter....Pages II-VIII
Identification of Acetylcholine and Related Esters of Biological Origin....Pages 1-39
Choline Acetylase....Pages 40-54
Formation, Storage, and Liberation of Acetylcholine....Pages 55-88
Classification and Comparative Enzymology of the Cholinesterases and Methods for their Determination....Pages 89-128
Ontogenesis of Cholinesterases....Pages 129-186
Cytological Distributions and Physiological Functions of Cholinesterases....Pages 187-298
The Active Site of Acetylcholinesterase and Related Esterases and its Reactivity towards Substrates and Inhibitors....Pages 299-373
Structure-Activity Relationships of the Reversible Anticholinesterase Agents....Pages 374-427
Structure-Activity Relationships of the Organophosphorus Anticholinesterase Agents....Pages 428-485
Metabolism of Organophosphorus Anticholinesterase Agents....Pages 486-504
Actions at Autonomic Effector Sites....Pages 505-529
Actions at Autonomic Ganglia....Pages 530-569
Actions at the Neuromuscular Junction....Pages 570-678
Actions at the Central Nervous System....Pages 679-700
Actions on Axons, and Evidence for the Role of Acetylcholine in Axonal Conduction....Pages 701-740
Actions on Insects and Other Invertebrates....Pages 741-798
Ontogenetic Effects....Pages 799-832
Toxicological Evaluation of the Anticholinesterase Agents....Pages 833-857
Neurotoxicity of Organophosphorus Compounds....Pages 858-882
Pharmacological Antagonists of the Anticholinesterase Agents....Pages 883-920
Reactivation of Phosphorylated Acetylcholinesterase....Pages 921-988
Anticholinesterase Intoxication in Man and its Treatment....Pages 989-1027
Therapy of Myasthenia Gravis....Pages 1028-1050
Local Use of Anticholinesterase Agents in Ocular Therapy....Pages 1051-1080
Back Matter....Pages 1081-1220