Cholinergic Mechanisms and Psychopharmacology

Front Matter....Pages i-xiv
The Binding of Acetylcholine to its Nicotinic Receptor....Pages 1-23
Correlation Between the Binding Properties and Pharmacological Responses of Muscarinic Receptors....Pages 25-33
Biochemical Characterization of Muscarinic Cholinergic Receptors in Huntington’s Disease....Pages 35-47
Characterization of Presynaptic Muscarinic Receptors in Central Cholinergic Neurons....Pages 49-60
Are There Two Forms of Nicotinic Acetylcholine Receptor?....Pages 61-75
Immunofluorescence Analysis of Surface Acetylcholine Receptors on Muscle: Modulation by Auto-Antibodies....Pages 77-92
Recent Advances in Histochemical Techniques for the Study of Central Cholinergic Mechanisms....Pages 93-124
Histochemical and Pharmacological Evidence of the Function of Butyrylcholinesterase....Pages 125-137
Estimation of Acetylcholine and the Dynamics of its Metabolism....Pages 139-162
Radioimmunoassay for Acetylcholine....Pages 163-168
Microwave Fixation for the Study of Acetylcholine Metabolism....Pages 169-179
Acetylcholine and Choline in Human Plasma and Red Blood Cells: A Gas Chromatograph Mass Spectrometric Evaluation....Pages 181-195
Studies on the Mechanism of Action of Choline Acetyltransferase....Pages 197-206
Activation of Choline Acetyltransferase by Chloride: A Possible Regulatory Mechanism....Pages 207-221
Comparative Immunochemistry of Mammalian Brain and Eel Electric Tissue Acetylcholinesterases....Pages 223-229
Constituents of Acetylcholinesterase....Pages 231-237
Structure of Acetylcholinesterase: Its Relationship to the Postsynaptic Membrane....Pages 239-251
If Cyclic GMP is a Neuronal Second Messenger What is the Message?....Pages 253-260
Acetylcholine and Cyclic GMP....Pages 261-266
Control of Nuclear Function in Chromaffin Cells by Persistent Activation of Nicotinic Receptors....Pages 267-284
Muscarinic Stimulation and cGMP Synthesis in the Nervous System....Pages 285-295
The Present Status of the Vesicle Hypothesis....Pages 297-322
The Electromotor System of Torpedo as a Model Cholinergic System....Pages 323-345
The Endocytotic Role of Vesicles at the Cholinergic Synapse....Pages 347-357
Nerve Terminal Sacs from Torpedo Electric Organ: A New Preparation for the Study of Presynaptic Cholinergic Mechanisms at the Molecular Level....Pages 359-375
Acetylcholine Compartments in Frog Muscle....Pages 377-386
Acetylcholine Mediated Axon-Schwann Cell Relationships in the Squid Nerve Fiber....Pages 387-399
Muscarinic Modulation of Acetylcholine Release from the Myenteric Plexus of the Guinea Pig Small Intestine....Pages 401-410
Source of the Acetyl Group in Acetylcholine....Pages 411-430
The Source of Choline for Acetylcholine Synthesis....Pages 431-445
Characteristics and Significance of Sodium-Dependent, High Affinity Choline Uptake....Pages 447-456
Factors Affecting Choline Uptake by Ganglia and the Relationship Between Choline Uptake and Acetylcholine Synthesis....Pages 457-464
Studies on Substrates, Inhibitors and Modifiers on the High Affinity Choline Transport-Acetylation System Present in Rat Brain Synaptosomes....Pages 465-480
Control of Acetylcholine Synthesis in Motor Nerve Terminals....Pages 481-496
Pyruvate Utilization, Choline Uptake and Acetylcholine Synthesis....Pages 497-509
Regulation of Acetylcholine Synthesis in Rat Brain....Pages 511-524
Effect of Choline on Cholinergic Function....Pages 525-538
Uptake of Choline in Nerve Cell Cultures: Correlation with the Endogenous Pool of Choline....Pages 539-550
Endogenous Modulators of Acetylcholine Turnover Rate....Pages 551-563
Effects of Polypeptide Neurotoxins on Acetylcholine Storage and Release....Pages 565-585
Presynaptic Modulation by Norepinephrine and Dopamine of Acetylcholine Release in the Peripheral and Central Nervous System....Pages 587-603
Drug Stimulation of Acetylcholine Output from the Cerebral Cortex....Pages 605-614
Pharmacological Evidence for a Serotoninergic-Cholinergic Link in the Striatum....Pages 615-627
Modulation of Acetylcholine Turnover in Brain Regions....Pages 629-642
Effect of Atropine on Acetylcholine Metabolism in the Mouse Brain....Pages 643-655
The Uptake of Acetylpyrrolidinecholine — A False Cholinergic Transmitter — Into Mammalian Cerebral Cortical Synaptic Vesicles....Pages 657-672
Effects of Δ9-Tetrahydrocannabinol on Regional Brain Acetylcholine....Pages 673-678
Exploitable Aspects of Central Cholinergic Functions, Particularly with Respect to the EEG, Motor, Analgesic and Mental Functions....Pages 679-708
Cholinergic Substrates of Behavior....Pages 709-731
Central Cholinergic Dysfunctions in Man: Clinical Manifestations and Approaches to Diagnosis and Treatment....Pages 733-745
Plasma Choline in Healthy Subjects and in Huntington’s Chorea Patients on High Oral Doses of Choline Chloride....Pages 747-753
Cholinergic Dysfunction in Mania and Movement Disorders....Pages 755-779
Cholinergic Modulation of Sleep, Growth Hormone and Analgesia in Normal Volunteers....Pages 781-789
Cholinergic Systems and Disorders of Carbohydrate Catabolism....Pages 791-803
Cholinergic Mechanisms in Schizophrenia, Mania and Depression....Pages 805-815
Physostigmine in the Treatment of Drug Overdose....Pages 817-825
Back Matter....Pages 827-885