Chemists’ Views of Imaging Centers

Front Matter....Pages i-xiii
The Role of Chemists in Developing Radiopharmaceutical Industry and Applications: Introductory Remarks....Pages 1-2
The Basics of Positron Emission Tomographic (PET) Imaging....Pages 3-26
PET: A Biochemical and Physiological Measuring Modality....Pages 27-34
Layout and Planning of a University Hospital Clinical Cyclotron/PET Facility....Pages 35-38
Evaluating the Utmck PET Center: An Organizational and Financial Analysis....Pages 39-48
European Concerted Action in PET — Activities in Radiochemistry....Pages 49-58
Pharmacy Practice and Positron Emission Tomography....Pages 59-69
Clinical Imaging Centers: The Role of State Radiation Control Programs....Pages 71-81
PET: The Governmental Reimbursement Perspective....Pages 83-86
Review of Radiopharmaceutical IND’s and NDA’s....Pages 87-96
Compliance with Good Manufacturing Practice....Pages 97-103
The Regulatory Process: The Institute for Clinical PET’s Experience....Pages 105-112
USP Activities and PET Radiopharmaceuticals....Pages 113-116
Managing the Obstacles in the Path to Regulatory Approval of PET....Pages 117-122
Laboratory and Cyclotron Requirements for Pet Research....Pages 123-131
Truly Frugal Pet: Is It Possible?....Pages 133-139
RFQ’s for Pet Radionuclide Production....Pages 141-150
Strategies in Synthesizing Short-Lived Radiopharmaceuticals for Positron Emission Tomography....Pages 151-156
Role of Current Good Manufacturing Practices in Establishment of Quality Assurance for in-House Radiopharmaceuticals....Pages 157-168
Quality Control for 11 C and 18 F Radiopharmaceuticals in the Research Environment....Pages 169-174
Trend Analysis of Quality Control Data....Pages 175-188
Quality Assurance of Radiolabeled Proteins, Peptides and Antisense Oligonucleotides....Pages 189-209
Reactor Isotope Quality Assurance....Pages 211-216
Analytical Instrumentation in the QC of Pet Radiopharmaceuticals....Pages 217-224
Development and Production of Radiopharmaceuticals for PET....Pages 225-235
New Pet Tracers for Cerebral Dopamine: Should 6-[ 18 F]Fluoro-L-Dopa be Replaced?....Pages 237-247
Design, Structure-Activity, Labelling and Purity in the Development of Receptor Interacting Radiohalogenated Tracers....Pages 249-256
Halogenated Benzamides as Ligands for Cerebral Dopamine Receptors....Pages 257-264
Development of Fluorine-18 Radiopharmaceuticals for Dopamine Neuroreceptors....Pages 265-275
Radionuclides and Their Application in Oncology Research....Pages 277-284
Positron Emitting Radiotracers for in Vivo Plant Research....Pages 285-289
Production and Application of 123 I-Labeled M-Iodobenzylguanidine ( 123 I-MIBG)....Pages 291-295
Chemistry, Radiochemistry and Applications of Potassium Isotopes....Pages 297-303
 19 F MR Characterization of Fluorinated Proteins and Relaxation Rate Enhancement with Gd-DTPA for Faster Imaging....Pages 305-313
Recovery of Bi-213 from an Ac-225 Cow: Application to the Radiolabeling of Antibodies with Bi-213....Pages 315-322
Application of Fullerenes in Biomedical Imaging....Pages 323-328
High Pressure H 2 18 O Target for the Production of [ 18 F]Fluoride Ion....Pages 329-338
Requirements for Production Targets for Middle-Energy Cyclotrons....Pages 339-345
Synthesis of Fluorine-18 Labeled Compounds for Brain Imaging....Pages 347-356
Solid Phase Reagents in Radiosynthesis....Pages 357-366
Fluorine-18 Labeling of Radiopharmaceuticals for PET Studies: Main Aspects and Problems Encountered in Chemical Syntheses....Pages 367-382
Distribution and Quantification of 18 F-Activity Produced Via 20 Ne(d,α) 18 F Reaction in a Gas Target....Pages 383-389
Twenty Years as a Chemist in a Positron Emission Tomography Center....Pages 391-400
Clinical Blood Flow Measurement with [ 15 O] Water and Positron Emission Tomography (PET)....Pages 401-417
Radiofluorinated Enzyme Probes of Dopaminergic Function....Pages 419-424
Routine Production of [ 18 F]F 2 from 11 MeV Proton-Only Cyclotron and Its Use for the Synthesis of 18 F-Tracers for Heart and Brain....Pages 425-429
The Hammersmith Philosophy for PET Chemistry Automation....Pages 431-443
The Use of Microwaves for the Automated Production of Radiopharmaceuticals....Pages 445-454
Reverse Robotics: Interactive Machines for Controlling People in a Complex Laboratory Environment....Pages 455-459
Automated Radiochemistry Through Transducers: Light from the Far Side....Pages 461-469
Homochiral Radioligands for PET: Aspects of Asymmetric Synthesis, Analysis and Behaviour In Vivo ....Pages 471-484
Fluorinated Tropinyl Esters for Application with Pet....Pages 485-496
Preparation and Examination of Labelled Stereoisomers in Vivo by Pet....Pages 497-511
Radiolabeled Tamoxifen Analogues for Imaging Breast Cancer with Spect....Pages 513-526
Back Matter....Pages 527-537