Chemical Factors in Hypertension: A collection of papers and discussion presented at the Symposium on Chemical Factors in Hypertension - 115th Ntl. Mtg. San Francisco, March 28 to April 1, 1949 (Advances in Chemistry Series)

Title......Page 1
Copyright......Page 2
FOREWORD......Page 3
Role of Adrenergic Blockade......Page 4
Humoral Pressor Substances and Their 
Relation to Arterial Hypertension......Page 6
Effects of Psychic Disturbances......Page 7
Table I . Pressor Substances Possibly Related to Hypertension*......Page 8
Nephrogenic Protein Pressor Substances......Page 9
Figure 2. Oxygen Uptake by Amine Oxidase Preparations and 
Tyramine, Hypertensin (Angiotonin), and Histamine......Page 10
Peptide Pressor Agents......Page 12
Amine Pressor Substances......Page 13
Substances Probably of Amine Nature......Page 15
Table III . Pressor Activity of Aminelike Compounds in the Rat......Page 16
Amine Oxidase and Amines......Page 17
Nicotine Bases......Page 18
Adrenal Cortical Hormones......Page 19
Figure 3. Effect of Intravenously Administered Amine Oxidase on Blood 
Pressure and Blood Urea Nitrogen of Hypertensive Dogs......Page 20
Figure 4. Prevention of Pressor Action of Renin and Hypertensin (Angiotonin) by Amine 
Oxidase......Page 21
Figure 5. Prevention of Pressor Action of Renin and Hypertensin by Amine 
Oxidase......Page 22
Summary and Conclusions......Page 23
Literature Cited......Page 24
Discussion of Paper on Humoral Pressor Substances 
and Their Relation to Arterial Hypertension......Page 25
Neurogenic Hypertension......Page 27
Table I . Cardiovascular Characteristics of Various Types of Hypertension......Page 28
Renal Hypertension......Page 29
Factors in Blood Pressure Regulation......Page 30
Sympatho-adrenal Factors in Development of Hypertension......Page 31
Figure 2. Possible Contributions to Maintenance of Systemic
Arterial Pressure during Neurogenic Hypertension......Page 32
Adrenergic Blocking Agents......Page 33
Figure 3. Possible Contributions to Maintenance of Systemic Arterial
Pressure during Renal (and Perhaps Essential) Hypertension......Page 34
Ergot Alkaloids......Page 35
Summary......Page 36
Literature Cited......Page 37
Discussion of Paper on Role of Sympathetic Blockade 
in the Therapy of Hypertension......Page 39
Biosynthesis and Metabolism of 
Phenylethyl (Pressor) Amines......Page 40
Figure 1. Effect of Unpleasant Interview on Cardiac Stroke Vol ­
ume, Blood Pressure, Renal Blood Flow, Filtration Fraction, and
Urine Flow of Patient......Page 41
Figure 2. Effect of Reassurance and Sedation on Blood Pressure 
and Renal Functions of Hypertensive Patient......Page 42
Figure 3. Effect of Hepatic Nerve Stimulation......Page 43
Synthesis of Pressor Amines......Page 44
Table 1. Alternative Schemes for  Synthesis......Page 45
Figure 4. Blood Pressure Records from Anesthetized Cat before and following 
Administration of Adrenolytic Agent......Page 46
Figure 5. Anaerobic Decarboxylation......Page 47
Figure 6. Inhibitory Effect of Amines......Page 48
Figure 7. Pressor Response in Anesthetized Cat......Page 49
Figure 8. Blood Pressure Response......Page 50
Elimination and Inactivation of Pressor Amines......Page 51
Figure 9. Blood Pressure Response to Unclampîng of Opposite Kidney......Page 52
Figure 10. Pressor Response to Intravenous Injection......Page 53
Figure 11. Effect of Intravenously Injected Phenylserine......Page 54
Figure 12. Effect of Intravenously Injected /-Epinephrine,......Page 55
Comment......Page 56
Bibliography......Page 57
Discussion of Paper on Biosynthesis and Metabolism 
of Phenylethyl (Pressor) Amines......Page 60
Literature Cited......Page 61