Chemical Carcinogenesis 2: Modulating Factors

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Nuclear Oncogenes as Transcription Factors....Pages 3-9
Control of Hepatocyte Growth by Positive and Negative Growth Regulators and Mitogenic Triggers: Implications for Hepatic Neoplasia....Pages 11-17
Cell Cycle Dependent Regulation of Poly(ADP-Ribose) Polymerase Gene Expression....Pages 19-27
Different Expression of Cell Cycle Related Genes during Liver Regeneration and Liver Hyperplasia....Pages 29-38
S-Adenosylmethionine Content, DNA Methylation and Gene Expression in Regenerating Liver....Pages 39-47
Gene Activation and Deactivation during Multistage Hepatocarcinogenesis in the Rat....Pages 49-64
Biochemical and Molecular Perturbations Induced in Preneoplastic Tissue by a S-Adenosyl-L-Methionine Load....Pages 65-86
Alterations of Cell Surface Receptors and Expression of Cellular Oncogenes in the Liver of Rats Fed a Hypolipidemic Peroxisome Proliferator....Pages 87-97
Growth Hormone-Regulated Expression of the c- myc Gene during Sex-Differentiated Promotion of Rat Liver Carcinogenesis....Pages 99-109
In Situ Hybridization of Ha-RAS during Rat Liver Carcinogenesis....Pages 111-118
Mutations in the H-ras Proto-Oncogene in Early Precancerous Liver Lesions of the B6C3F1 Mouse....Pages 119-121
Transformation of Human Epithelial Cells by Recombinant Human Papillomavirus DNA Associated with Cervical Cancer....Pages 123-135
Front Matter....Pages 137-137
Cancer Families and Susceptibility to Cancer....Pages 139-144
Cancer Syndromes in Humans....Pages 145-157
Case-Control Studies on Cancer Risk in G6PD-Deficient Male Populations....Pages 159-164
Genetic Susceptibility to Murine Hepatocarcinogenesis....Pages 165-176
MHC-Linked Genes Controlling Growth and Reproduction Influence the Susceptibility to Diethylnitrosamine-Induced Carcinogenesis....Pages 177-186
Front Matter....Pages 187-187
Metabolic Aberrations and Metamorphosis during Chemical Carcinogenesis....Pages 189-202
Persistent Rat Liver Nodules Differ from Normal Liver, Regenerating Liver and Early Nodules both in Terms of Proteins of the Nuclear Matrix and Chromatin Condensation....Pages 203-212
Intracellular Na + , K + , H + and Cl − Activities and Membrane Potentials during the 4-Dimethylaminoazobenzene-Induced Rat Hepatocarcinogenesis....Pages 213-217
Front Matter....Pages 187-187
Analysis of the Effects of Modifying Agents on Proliferation and Enzyme Phenotype in Focal Preneoplastic and Neoplastic Liver Lesions in Rats....Pages 219-229
Epidermal Growth Factor-Induced Cell Proliferation and EGF Binding in Preneoplastic Foci in the Rat Liver....Pages 231-236
The Different Calcium Requirements of the Mitogenic Effects Elicited in Primary Neonatal Rat Hepatocytes by the Diterpene Phorbol Esters 12-O-Tetradecanoylphorbol-13-Acetate and Sapintoxin A....Pages 237-249
Glucose-6-phosphate Dehydrogenase Molecular forms in Different Experimental Models of Hepatic Cell Proliferation....Pages 251-256
Estrogen Dependent Growth of a Rat Pituitary Tumor (MtT/F84)....Pages 257-264
Deterministic Coupling between Cellular Bioenergetics, Cholesterol Synthesis, Cell Proliferation and Cancer....Pages 265-288
Dolichyl Phosphate as a Regulator of Cell Growth....Pages 289-297
Regulation of Cholesterol Metabolism in Normal and Malignantly Transformed Tissue in Vivo....Pages 299-309
Cholesterol Metabolism and Proliferative Processes....Pages 311-320
Serum LCAT and Lipid Levels in grc − -Bearing Rats with Liver Cancer....Pages 321-326
Covalent Modification of Proteins by Farnesol and the Control of Cell Proliferation....Pages 327-335
Repeated Treatments with a Low HNE Concentration Affect K562 Cell Proliferation....Pages 337-342
Arachidonic Acid Enrichment Augments the Malonildialdehyde Production in Yoshida AH-130 Hepatoma Cells....Pages 343-348
Modulation of Phosphatidylinositol-4,5-Diphosphate (PIP2) Phospholipase C Activity by 4-Hydroxyalkenals....Pages 349-356
The Role of Hepatic Metabolism in Sex Differentiation of Chemical Hepatocarcinogenesis in the Rat....Pages 357-365
Changes of Rat Liver Glutathione Peroxidase, Glutathione Reductase and Glutathione Transferase 7–7 by Lead Nitrate Treatment....Pages 367-372
High Affinity P-450 form for the Metabolic Activation of Den in Liver of Acetone-Induced Rats but Not of Hamsters....Pages 373-379
Genotoxicity of Chloroethanes and Structure-Activity Relationships....Pages 381-391
Genetical and Biochemical Studies on Three Halogenated Ethanes....Pages 393-402
“In Vivo” Interaction of Methionine and Cysteine Sulfur with Rat Liver tRNA....Pages 403-407
Front Matter....Pages 187-187
Synthesis and Secretion of Cathepsin D in Normal and Tumor Human Cells....Pages 409-418
Front Matter....Pages 419-419
Relationship between Cell Proliferation and Cell Death....Pages 421-431
An in Vitro Model for Apoptosis: Uptake and Degradation of Apoptotic Bodies....Pages 433-442
Protein Catabolism and Apoptosis in AH-130 Hepatoma Cells and in the Host Rat Liver....Pages 443-449
Protein Synthesis during Programmed (Physiological) Cell Death....Pages 451-459
Role of Tissue Transglutaminase in the Formation of Apoptotic Bodies....Pages 461-471
The Induction of Apoptosis in Human Malignant Keratinocytes by Antisense DNA to Retinoid Receptors: Keys to the Function of Apoptosis and Vitamin A....Pages 473-492
Cell Death and Cell Proliferation in Experimental Hepatocarcinogenesis....Pages 493-502
Cell Death and Proliferation in Opisthorchis Viverrini-DHPN Induced Carcinogenesis in the Syrian Hamster Hepato-Pancreatic Axis....Pages 503-510
Ethionine-Induced Atrophy of Rat Parotid Glands Involves Apoptosis of Acinar Cells: Implications for Chemical Carcinogenesis....Pages 511-519
Apoptotic Effect of Skin Tumor Promoters on Thymocytes: Cell Death as a Possible Trigger for the Induction of Promotability (Conversion)....Pages 521-528
Chemoprevention of Rat Liver Carcinogenesis by S-Adenosylmethionine: Role of Remodeling and Apoptosis....Pages 529-551
The Occurrence of Apoptosis in Tumors and its Effect on Neoplastic Development....Pages 553-562
Stimulus Dependent Phenotypic Diversity in the Resistant Hepatocyte Model....Pages 563-577
Effects of 5-Azacytidine(5-AzC), 5-Bromodeoxyuridine(BrdU) and Diethyldithiocarbamate (DEDTC) on Diethylnitrosamine (DEN)-Induced Carcinogenesis in Rats....Pages 579-586
Modulation by a Choline Devoid Diet of Repair of Chemical Damage in Liver DNA....Pages 587-597
Is the Beta-Blocker DL-ZAMI 1305 a Tumor Promoter for Rat Liver?....Pages 599-610
Amplifying Effects of Uracil on Multi-Stage Bladder Carcinogenesis in Rats....Pages 611-618
Bombesin and Hepatocyte Proliferation....Pages 619-623
Inhibition of Growth of Breast Cancer in Vitro by the Ribosome-Inactivating Protein Saporin 6....Pages 625-629
Front Matter....Pages 419-419
Determination of PAH-DNA Adducts in Lung Tissue of Cancer Patients....Pages 631-634
Theoretical Studies of Flavone Acetic Acids....Pages 635-646
Back Matter....Pages 647-653