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دسته بندی: علم شیمی ویرایش: نویسندگان: Stuart L. Schreiber, Tarun M. Kapoor, Günther Wess سری: ISBN (شابک) : 9783527311507, 3527311505 ناشر: Wiley-VCH سال نشر: 2007 تعداد صفحات: 1214 زبان: English فرمت فایل : DJVU (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 14 مگابایت
در صورت تبدیل فایل کتاب Chemical Biology: From Small Molecules to Systems Biology and Drug Design به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب زیست شناسی شیمیایی: از مولکول های کوچک گرفته تا سیستم های زیست شناسی و طراحی دارو نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
Edited by the world leaders in this emerging field, this
three-volume handbook is designed to become the landmark
reference on this exciting new branch of chemistry and
biology.
Following an introductory section, the authors discuss the use
of small molecules to explore biology, discovering small
molecule probes for biological mechanisms and expanding the
scope of chemical synthesis. Further sections cover chemical
informatics, drug discovery and systems biology, and the whole
work is rounded off by the outlook and perspectives for this
field.
No academic institution or pharmaceutical company can possibly
miss out on this highly authoritative work. Content:
Chapter 1 Chemistry and Biology — Historical and Philosophical
Aspects (pages 3–67): Gerhard Quinkert, Holger Wallmeier,
Norbert Windhab and Dietmar Reichert
Chapter 2 Using Small Molecules to Unravel Biological
Mechanisms (pages 71–94): Michael A. Lampson and Tarun M.
Kapoor
Chapter 2 Using Natural Products to Unravel Cell Biology (pages
95–114): Jonathan D. Gough and Craig M. Crews
Chapter 3 Revealing Biological Specificity by Engineering
Protein?Ligand Interactions (pages 115–139): Matthew D. Simon
and Kevan M. Shokat
Chapter 3 Controlling Protein Function by Caged Compounds
(pages 140–173): Andrea Giordano, Sirus Zarbakhsh and Carsten
Schultz
Chapter 3 Engineering Control Over Protein Function;
Transcription Control by Small Molecules (pages 174–197): John
T. Koh
Chapter 4 Chemical Complementation: Bringing the Power of
Genetics to Chemistry (pages 199–226): Pamela Peralta?Yahya and
Virginia W. Cornish
Chapter 4 Controlling Protein–Protein Interactions Using
Chemical Inducers and Disrupters of Dimerization (pages
227–249): Tim Clackson
Chapter 4 Protein Secondary Structure Mimetics as Modulators of
Protein–Protein and Protein?Ligand Interactions (pages
250–269): Hang Yin and Andrew D. Hamilton
Chapter 5 Synthetic Expansion of the Central Dogma (pages
271–295): Masahiko Sisido
Chapter 6 Forward Chemical Genetics (pages 299–354): Stephen J.
Haggarty and Stuart L. Schreiber
Chapter 7 Reverse Chemical Genetics – An Important Strategy for
the Study of Protein Function in Chemical Biology and Drug
Discovery (pages 355–384): Rolf Breinbauer, Alexander Hillisch
and Herbert Waldmann
Chapter 7 Chemical Biology and Enzymology: Protein
Phosphorylation as a Case Study (pages 385–402): Philip A.
Cole
Chapter 7 Chemical Strategies for Activity?based Proteomics
(pages 403–426): Nadim Jessani and Benjamin F. Cravatt
Chapter 8 The Biarsenical?tetracysteine Protein Tag: Chemistry
and Biological Applications (pages 427–457): Stephen R.
Adams
Chapter 8 Chemical Approaches to Exploit Fusion Proteins for
Functional Studies (pages 458–479): Anke Arnold, India Sielaff,
Nils Johnsson and Kai Johnsson
Chapter 9 Diversity?oriented Synthesis (pages 483–518): Derek
S. Tan
Chapter 9 Combinatorial Biosynthesis of Polyketides and
Nonribosomal Peptides (pages 519–536): Nathan A. Schnarr and
Chaitan Khosla
Chapter 10 Expressed Protein Ligation (pages 537–566): Matthew
R. Pratt and Tom W. Muir
Chapter 10 Chemical Synthesis of Proteins and Large
Bioconjugates (pages 567–592): Philip Dawson
Chapter 10 New Methods for Protein Bioconjugation (pages
593–634): Matthew B. Francis
Chapter 11 The Search for Chemical Probes to Illuminate
Carbohydrate Function (pages 635–667): Laura L. Kiessling and
Erin E. Carlson
Chapter 11 Chemical Glycomics as Basis for Drug Discovery
(pages 668–691): Daniel B. Werz and Peter H. Seeberger
Chapter 12 The Bicyclic Depsipeptide Family of Histone
Deacetylase Inhibitors (pages 693–720): Paul A. Townsend, Simon
J. Crabb, Sean M. Davidson, Peter W. M. Johnson, Graham Packham
and Arasu Ganesan
Chapter 13 Chemical Informatics (pages 723–759): Paul A.
Clemons
Chapter 13 WOMBAT and WOMBAT?PK: Bioactivity Databases for Lead
and Drug Discovery (pages 760–786): Marius Olah, Ramona Rad,
Liliana Ostopovici, Alina Bora, Nicoleta Hadaruga, Dan
Hadaruga, Ramona Moldovan, Adriana Fulias, Maria Mractc and
Tudor I. Oprea
Chapter 14 Managerial Challenges in Implementing Chemical
Biology Platforms (pages 789–803): Frank L. Douglas
Chapter 14 The Molecular Basis of Predicting Druggability
(pages 804–823): Bissau Al?Lazikani, Anna Gaulton, Gaia
Paolini, Jerry Lanfear, John Overington and Andrew
Hopkins
Chapter 15 The Target Family Approach (pages 825–851): Hans
Peter Nestler
Chapter 15 Chemical Biology of Kinases Studied by NMR
Spectroscopy (pages 852–890): Marco Betz, Martin Vogtherr,
Ulrich Schieborr, Bettina Elshorst, Susanne Grimme, Barbara
Pescatore, Thomas Langer, Krishna Saxena and Harald
Schwalbe
Chapter 15 The Nuclear Receptor Superfamily and Drug Discovery
(pages 891–932): John T. Moore, Jon L. Collins and Kenneth H.
Pearce
Chapter 15 The GPCR — 7TM Receptor Target Family (pages
933–978): Edgar Jacoby, Rochdi Bouhelal, Marc Gerspacher and
Klaus Seuwen
Chapter 15 Drugs Targeting Protein–Protein Interactions (pages
979–1002): Patrick Chene
Chapter 16 Prediction of ADMET Properties (pages 1003–1042):
Ulf Norinder and Christel A. S. Bergstrom
Chapter 17 Systems Biology of the JAK?STAT Signaling Pathway
(pages 1045–1060): Jens Timmer, Markus Kollmann and Ursula
Klingmuller
Chapter 17 Modeling Intracellular Signal Transduction Processes
(pages 1061–1081): Jason M. Haugh and Michael C. Weiger
Chapter 18 Genome?wide Gene Expression Analysis: Practical
Considerations and Application to the Analysis of T?cell
Subsets in Inflammatory Diseases (pages 1083–1117): Lars Rogge
and Elisabetta Bianchi
Chapter 18 Scanning the Proteome for Targets of Organic Small
Molecules Using Bifunctional Receptor Ligands (pages
1118–1139): Nikolai Kley
Chapter 19 Chemical Biology – An Outlook (pages 1143–1150):
Gunther Wess
Cover......Page 1
Frontmatter......Page 2
Structures and Symbols......Page 11
A......Page 13
B......Page 54
C......Page 67
D......Page 108
E......Page 121
F......Page 135
G......Page 144
H......Page 164
I......Page 180
J......Page 194
K......Page 196
L......Page 203
M......Page 216
N......Page 239
O......Page 254
P......Page 260
Q......Page 321
R......Page 322
S......Page 336
T......Page 364
U......Page 384
V......Page 389
W......Page 395
X......Page 396
Y......Page 397
Z......Page 398