Chembiomolecular Science: At the Frontier of Chemistry and Biology

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Chemistry of Mycolactones, the Causative Toxins of Buruli Ulcer....Pages 3-13
Practical Synthesis of Tamiflu and Beyond....Pages 15-21
An Approach Toward Identification of Target Proteins of Maitotoxin Based on Organic Synthesis....Pages 23-35
Inhibitors of Fatty Acid Amide Hydrolase....Pages 37-49
Small Molecule Tools for Cell Biology and Cell Therapy....Pages 51-58
Toward the Discovery of Small Molecules Affecting RNA Function....Pages 59-67
New Insights from a Focused Library Approach Aiming at Development of Inhibitors of Dual-Specificity Protein Phosphatases....Pages 69-81
The Deep Oceans as a Source for New Treatments for Cancer....Pages 83-91
Search for New Medicinal Seeds from Marine Organisms....Pages 93-101
Identification of Protein–Small Molecule Interactions by Chemical Array....Pages 103-111
Front Matter....Pages 113-113
Small Molecule-Induced Proximity....Pages 115-126
High-Throughput Screening for Small Molecule Modulators of FGFR2-IIIb Pre-mRNA Splicing....Pages 127-138
Identification of Signaling Pathways That Mediate Dietary Restriction-Induced Longevity in Caenorhabditis elegans ....Pages 139-144
Roles for the Stress-Responsive Kinases ASK1 and ASK2 in Tumorigenesis....Pages 145-153
Tailored Synthetic Surfaces to Control Human Pluripotent Stem Cell Self-Renewal....Pages 155-165
Cell-Surface Glycoconjugates Controlling Human T-Lymphocyte Homing: Implications for Bronchial Asthma and Atopic Dermatitis....Pages 167-176
Establishment of a Novel System for Studying the Syk Function in B Cells....Pages 177-182
Visual Screening for the Natural Compounds That Affect the Formation of Nuclear Structures....Pages 183-192
Versatile Orphan Nuclear Receptor NR4A2 as a Promising Molecular Target for Multiple Sclerosis and Other Autoimmune Diseases....Pages 193-200
Antiviral MicroRNA....Pages 201-205
Front Matter....Pages 113-113
Synaptic Function Monitored Using Chemobiomolecular Indicators....Pages 207-215
Front Matter....Pages 217-217
Practical Catalytic Asymmetric Synthesis of a Promising Drug Candidate....Pages 219-228
Hunting the Targets of Natural Product-Inspired Compounds....Pages 229-238
Chemical Approaches for Understanding and Controlling Infectious Diseases....Pages 239-247
Nongenomic Mechanism-Mediated Renal Fibrosis-Decreasing Activity of a Series of PPAR-γ Agonists....Pages 249-260
Novel Carbohydrate-Based Inhibitors That Target Influenza A Virus Sialidase....Pages 261-267
Multidrug Efflux Pumps and Development of Therapeutic Strategies to Control Infectious Diseases....Pages 269-279
Enzymes as Chemotherapeutic Agents....Pages 281-291
Mechanism of Action of New Antiinfectious Agents from Microorganisms....Pages 293-300
Correction of RNA Splicing with Antisense Oligonucleotides as a Therapeutic Strategy for a Neurodegenerative Disease....Pages 301-313
Modulation of Pre-mRNA Splicing Patterns with Synthetic Chemicals and Their Clinical Applications....Pages 315-319
Back Matter....Pages 321-325