Cellular and Biomolecular Recognition: Synthetic and Non-Biological Molecules

 Content: Cover --
 Title Page --
 Copyright Page --
 Table of Contents --
 Preface --
 List of Contributors --
 1 Development of Functional Materials from Rod-Like Viruses --
 1.1 Introduction --
 1.2 Overview --
 1.2.1 TMV --
 1.2.2 M13 Bacteriophage --
 1.3 Programmable Protein Shells --
 1.3.1 Chemical Modifications --
 1.3.2 Genetic Modifications --
 1.3.3 Chemical Modification in Combination with Genetic Mutation --
 1.4 Templated Syntheses of Composite Materials --
 1.4.1 Synthesis of Inorganic Materials Using TMV as the Template --
 1.4.2 Bacteriophage M13 as the Template --
 1.5 Self-Assembly of Rod-Like Viruses --
 1.5.1 Controlled 1D Assembly --
 1.5.2 Fabrication of Thin Films by 2D Self-Assembly --
 1.5.3 Controlling the 3D Assembly of TMV and M13 --
 1.6 Virus-Based Device and Applications --
 1.7 Outlook --
 References --
 2 Biomimetic Nanoparticles Providing Molecularly Defined Binding Sites 8230; Protein-Featuring Structures versus Molecularly Imprinted Polymers --
 2.1 Introduction --
 2.2 Core Materials and Functionalities --
 2.2.1 Inorganic Core Materials --
 2.2.2 Organic Core Materials --
 2.3 Functional Shells --
 2.3.1 Organic Shells --
 2.3.2 MIPs --
 2.4 Applications --
 2.4.1 Biopurification --
 2.4.2 Drug Delivery and Drug Targeting --
 2.5 Products --
 2.5.1 MIPs8230;Applications and Products --
 2.5.2 Luminex Assay --
 2.6 Conclusions --
 References --
 3 Interaction Between Silica Particles and Human Epithelial Cells: Atomic Force Microscopy and Fluorescence Study --
 3.1 Interaction of Silica with Biological Cells: Background --
 3.2 Interaction of a Silica Particle with the Cell Surface: How It Is Seen with AFM --
 3.2.1 AFM --
 3.2.2 AFM on Cells --
 3.2.3 AFM Probe Preparations --
 3.2.4 Models to Analyze the Cell Surface: Need for a Two-Layer Model --
 3.2.5 Experimental Data --
 3.3 Ultra-Bright Fluorescent Silica Particles to Be Used to Study Interaction with Cells --
 3.4 Ultra-Bright Fluorescent Silica Particles to Distinguish Between Cancer and Normal Cells --
 3.4.1 Methods and Materials --
 3.4.2 Experimental Results: Spectrofluorometric and Image Analysis of Cancer and Normal Cervix Cells --
 3.5 Conclusions --
 References --
 4 Chiral Molecular Imprinting as a Tool for Drug Sensing --
 4.1 Introduction --
 4.2 Electrochemical Drug Sensors --
 4.3 Optical Drug Sensors --
 4.4 Mass Drug Sensors --
 4.5 Conclusions and Summary --
 References --
 5 Catalytic Antibodies for Selective Cancer Chemotherapy --
 5.1 Introduction --
 5.2 Catalytic Antibodies Designed for Prodrug Activation --
 5.3 Catalytic Antibody 38C2 and Cancer Therapy --
 5.3.1 General Approach for Prodrug Activation with Antibody 38C2 --
 5.3.2 Bifunctional Antibodies for Targeted Chemotherapy --
 5.3.3 In Vitro and In Vivo Evaluations of Antibody 38C2-Catalyzed Prodrug Activation --
 5.3.4 Polymer Directed Enzyme Prodrug Therapy: An Approach to Target Antibody 38C2 to a Tumor Site --
 5.3.5 Chemical Adaptor Concept --
 5.3.6 Self-Immolative Dendrimers Concept --
 5.3.7 Prodrugs of Dynemicin and Doxorubicin Analogs --
 5.4 Chemically Programmed Antibodies --
 5.5 Outlook --
 References --
 6 Natural and Synthetic Stimulators of the Immune Response --
 6.1 Introduction --
 6.2 Lipopolysaccharide Endotoxin 8230; A Potent Immunostimulatory Molecule --
 6.3 LPS Recognition --
 6.4 Septic Shock --
 6.5 LPS Biosynthesis --
 6.6 Minimal, Modified Lip.
 Abstract:             With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design