Cells, Membranes, and Disease, Including Renal

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Investigation of Ischaemic Effects on Subcellular Structures by Centrifugation Methods....Pages 3-12
Investigation of Subcellular Derangements in Human Biopsy Material....Pages 13-24
Analytical Subcellular Studies in Alcoholic Liver Disease....Pages 25-34
Methodological Approaches in Studies of Altered Mitochondrial and Peroxisomal β-Oxidation....Pages 35-51
Pharmacological and Toxicological Aspects of Peroxisome Proliferators....Pages 53-65
Studies on the Mechanisms of Changes Produced in the Liver, Thyroid, Pancreas and Kidney by Hypolipidaemic Drugs and DI-(2-Ethylhexyl) Phthalate....Pages 67-78
The use of Cytochrome P-450 Isoenzymes as an Index of Endoplasmic Reticulum Changes....Pages 79-88
Drug-Induced Mitochondrial Proliferation....Pages 89-98
Ultrastructural Morphometric/Biochemical Approaches to Assessing Metal-Induced Cell Injury....Pages 99-108
Iron Overload, Lysosomes and Free Radicals....Pages 109-112
Glucocerebrosidase, a Membrane-Associated Lysosomal Enzyme Deficient in Gaucher Disease....Pages 113-126
Cytochemical Techniques Applied to Whole Tissue and Tissue Homogenates....Pages 127-132
Front Matter....Pages 133-134
Immunoelectron Microscopical Localization of Lysosomal Hydrolases in Normal and I-Cell Fibroblasts....Pages 135-140
Front Matter....Pages 141-141
Free Flow Electrophoresis: Its Application to the Separation of Cells and Cell Membranes....Pages 143-152
Counter-Current Chromatography as a Tool in Subcellular Studies....Pages 153-159
Flow Cytometry: A Tool in Studying Cellular Derangements....Pages 161-170
Interaction of Paf-Acether with the Human Platelet: Receptor Binding and Pharmacology....Pages 171-183
Front Matter....Pages 185-186
Aproaches Depending on Surface Distinctions....Pages 185-186
Front Matter....Pages 187-187
Membrane-Mediated Cytotoxicity: Measurement of Changes and their Prevention by Divalent Cations....Pages 189-198
Complement-Mediated Plasma-Membrane Damage: Effects on Cell Physiology, Prospects of Cell Recovery and Implications for Disease Mechanisms....Pages 199-209
Front Matter....Pages 187-187
Erythrocyte Membrane Derangements Associated with Sickle Cell Disease....Pages 211-217
The Membrane-Cytoskeletal Axis in Phagocytosing PMN-Leucocytes and Virally Transformed Fibroblasts....Pages 219-230
Front Matter....Pages 231-232
Studies on Cell Injury: Effects of Ion Regulation on Cell Membranes and the Cytoskeleton....Pages 233-234
The Glycoproteins and Fluidity of Multinodular Goiter Euthyroid Plasma Membranes....Pages 235-240
Front Matter....Pages 241-241
Gastroduodenal Epithelial Cells: The Role of the Apical Membrane in Mucosal Protection....Pages 243-254
Structural and Functional Aspects of the Intestinal Brush Border....Pages 255-267
Studies of the Mechanisms of Mucosal Iron Uptake....Pages 269-272
Pancreatic Acinar Cell Plasma-Membrane Enzymes Involved in Stimulus-Secretion Coupling....Pages 273-283
Front Matter....Pages 285-286
Epithelial Membranes in Digestive Tissues....Pages 285-286
Front Matter....Pages 287-287
Receptor-Mediated Uptake of a Toxin which Binds to Plasma-Membrane Ion Channels....Pages 289-297
Lysosomal Proteolysis in Cultured Hepatocytes....Pages 299-306
Hepatic Processing of Insulin: Characterization and Modulation....Pages 307-313
Receptor-Mediated Endocytosis in Rat Liver Parenchymal and Non-Parenchymal Cells, Studied by Means of Subcellular Fractionation in Density Gradients....Pages 315-325
Use of Chromogenic Peptide Substrates in the Study of Proteolytic Enzymes and Mechanisms Regulating them....Pages 327-333
Peptidases in Connective Tissue Degradation and Remodelling in Reproductive and Invasive Tissues....Pages 335-349
Brain Tumour Cell Invasion: Possible Role of Lysosomal Enzymes....Pages 351-357
Investigation of Tumour-Invasion Mechanisms....Pages 359-370
Front Matter....Pages 371-372
Plasma Membrane Distribution of Metalloproteinases and Cysteine Proteinases in Metastatic Human Cancer Cells....Pages 373-378
Proteases and Oxidants in Injury to Alveolar Epithelial Cells Caused by Lung-Derived Neutrophils In Vitro ....Pages 379-382
Autophagy and Protein Degradation in Rat Hepatocytes, Studied by Means of Subcellular Fractionation in Nycodenz Gradients....Pages 383-386
Front Matter....Pages 371-372
Immunochemical Techniques in the Study of Protein Degradation with Particular Reference to Collagen....Pages 387-393
Front Matter....Pages 395-395
A Nuclear Magnetic Resonance Approach to Investigate the Biochemical and Molecular Effects of Nephrotoxins....Pages 397-408
Enzyme Release in Nephrotoxicity and Renal Disease....Pages 409-416
The Investigation of Subcellular Derangements in Nephrotoxicity....Pages 417-426
Heterogeneity and Function of Kidney Cortex Lysosomes....Pages 427-432
Involvement of Kidney Lysosomes in the Nephrotoxicity of Cadmium and Other Metals....Pages 433-438
Lysosomal Populations in Kidney Cortex of Rats with Heavy Proteinuria....Pages 439-444
Immune Derangements in Experimental, Toxin-Induced Autoimmune Nephropathies....Pages 445-452
Glomerular Basement Membrane and the Inflammatory Response....Pages 453-464
Biochemical and Immunological Characterization of Basement Membranes in Renal Disease....Pages 465-474
Renal Investigations....Pages 475-478
Back Matter....Pages 479-491