Cell Biology and Pathology of Myelin: Evolving Biological Concepts and Therapeutic Approaches

Front Matter....Pages i-ix
Structure and Function of Myelin, an Extended and Biochemically Modified Cell Surface Membrane....Pages 1-12
Myelin Basic Protein, the “Executive” Molecule of the Myelin Membrane....Pages 13-25
Myelin-Associated Glycoprotein....Pages 27-36
Myelin/Oligodendrocyte Glycoprotein....Pages 37-49
Molecular Biology of Hereditary Motor and Sensory Neuropathies....Pages 51-59
Mutations of the Proteolipid Protein Gene....Pages 61-68
Myelin Proteins as Mediators of Signal Transduction....Pages 69-74
CNP in Myelination....Pages 75-82
The Role of the Gap Junction Protein Connexin32 in the Myelin Sheath....Pages 83-102
The Role of Myelin Po Protein....Pages 103-114
Posttranscriptional Regulation of Myelin Basic Protein Gene Expression....Pages 115-122
Molecular Control of Myelin Basic Protein Gene Expression....Pages 123-128
Role of cAMP during the Process of Demyelination and Remyelination in Peripheral Nerve....Pages 129-135
Characterization of an Axonal Protein Involved in Myelination....Pages 137-144
Do Secretory Pathway Snare Proteins Mediate Myelinogenesis?....Pages 145-155
Expression of the PLP Gene and a PLP-LacZ Transgene in Oligodendrocytes....Pages 157-163
Developmental Regulation of Schwann Cell Precursors and Schwann Cell Generation....Pages 165-172
Protein Kinase C Regulates Process Formation by Oligodendrocytes....Pages 173-185
Mechanism of Adhesion-Induced Regeneration/Differentiation of Oligodendrocytes....Pages 187-199
A Procedure for Isolating Schwann Cells Developed for Analysis of the Mouse Embryonic Lethal Mutation NF1 ....Pages 201-212
Expansion of Oligodendrocyte Progenitors for Myelin Repair....Pages 213-221
Generation of Oligodendrocyte Precursors from Human Neural Cells In Vitro ....Pages 223-233
Recent Insights into the Cellular Biology of Remyelination....Pages 235-243
Characterising the Adult Human Oligodendrocyte Progenitor....Pages 245-252
The Repair of Central Nervous System Myelin....Pages 253-264
Inhibition of Human and Rat Glial Cell Function by Anti-Inflammatory Cytokines, Antioxidants, and Elevators of cAMP....Pages 265-276
Oligodendrocytes and Axonal Regrowth....Pages 277-282
Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells....Pages 283-298
Axonal Regeneration in the Fish and Amphibian CNS....Pages 299-308
Role of MAG as an Axon Growth Inhibitory Protein for Regeneration of Injured Neurons in the CNS....Pages 309-317
Schwann Cells as Facilitators of Axonal Regeneration in CNS Fiber Tracts....Pages 319-333
Olfactory Ensheathing Cells can be Induced to Express a Myelinating Phenotype....Pages 335-345
Overcoming Myelin-Associated Inhibition of Axonal Regeneration after CNS Injury....Pages 347-363
Abstracts....Pages 365-386
Back Matter....Pages 365-398